Validated Spectrophotometric Quantification of Aripiprazole in Pharmaceutical Formulations by Using Multivariate Technique
Purpose: An accurate and precise UV spectrophotometric method with multivariate calibration technique for the determination of aripiprazole in pharmaceutical formulations has been described. Methods: This technique is based on the use of the linear regression equations by using the relationship betw...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2013-08-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-469.pdf |
| _version_ | 1811250623128010752 |
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| author | Kandikonda Sandeep Madhusudhanareddy Induri Muvvala Sudhakar |
| author_facet | Kandikonda Sandeep Madhusudhanareddy Induri Muvvala Sudhakar |
| author_sort | Kandikonda Sandeep |
| collection | DOAJ |
| description | Purpose: An accurate and precise UV spectrophotometric method with multivariate calibration technique for the determination of aripiprazole in pharmaceutical formulations has been described. Methods: This technique is based on the use of the linear regression equations by using the relationship between concentration and absorbance at five different wavelengths. The aripiprazole shows absorption maxima at 255 nm and obeyed Beer’s law in the range of 5-30 μg/mL. Results: The results were treated statistically and were found highly accurate, precise and reproducible. This statistical approach gives optimum results for the eliminating fluctuations coming from instrumental or experimental conditions. Conclusion: It was concluded that the proposed method is simple, easy to apply, economical and could be used as an alternative to the existing spectrophotometric and non-spectrophotometric methods for the routine analysis of aripiprazole in pharmaceutical formulations. |
| first_indexed | 2024-04-12T16:07:21Z |
| format | Article |
| id | doaj.art-9a9127716302420ead65a97147dbf622 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-04-12T16:07:21Z |
| publishDate | 2013-08-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-9a9127716302420ead65a97147dbf6222022-12-22T03:26:01ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082013-08-013246947210.5681/apb.2013.078Validated Spectrophotometric Quantification of Aripiprazole in Pharmaceutical Formulations by Using Multivariate TechniqueKandikonda SandeepMadhusudhanareddy InduriMuvvala SudhakarPurpose: An accurate and precise UV spectrophotometric method with multivariate calibration technique for the determination of aripiprazole in pharmaceutical formulations has been described. Methods: This technique is based on the use of the linear regression equations by using the relationship between concentration and absorbance at five different wavelengths. The aripiprazole shows absorption maxima at 255 nm and obeyed Beer’s law in the range of 5-30 μg/mL. Results: The results were treated statistically and were found highly accurate, precise and reproducible. This statistical approach gives optimum results for the eliminating fluctuations coming from instrumental or experimental conditions. Conclusion: It was concluded that the proposed method is simple, easy to apply, economical and could be used as an alternative to the existing spectrophotometric and non-spectrophotometric methods for the routine analysis of aripiprazole in pharmaceutical formulations.http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-469.pdfAripiprazoleTabletsUV-SpectrophotometryMultivariate Technique |
| spellingShingle | Kandikonda Sandeep Madhusudhanareddy Induri Muvvala Sudhakar Validated Spectrophotometric Quantification of Aripiprazole in Pharmaceutical Formulations by Using Multivariate Technique Advanced Pharmaceutical Bulletin Aripiprazole Tablets UV-Spectrophotometry Multivariate Technique |
| title | Validated Spectrophotometric Quantification of Aripiprazole in Pharmaceutical Formulations by Using Multivariate Technique |
| title_full | Validated Spectrophotometric Quantification of Aripiprazole in Pharmaceutical Formulations by Using Multivariate Technique |
| title_fullStr | Validated Spectrophotometric Quantification of Aripiprazole in Pharmaceutical Formulations by Using Multivariate Technique |
| title_full_unstemmed | Validated Spectrophotometric Quantification of Aripiprazole in Pharmaceutical Formulations by Using Multivariate Technique |
| title_short | Validated Spectrophotometric Quantification of Aripiprazole in Pharmaceutical Formulations by Using Multivariate Technique |
| title_sort | validated spectrophotometric quantification of aripiprazole in pharmaceutical formulations by using multivariate technique |
| topic | Aripiprazole Tablets UV-Spectrophotometry Multivariate Technique |
| url | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-469.pdf |
| work_keys_str_mv | AT kandikondasandeep validatedspectrophotometricquantificationofaripiprazoleinpharmaceuticalformulationsbyusingmultivariatetechnique AT madhusudhanareddyinduri validatedspectrophotometricquantificationofaripiprazoleinpharmaceuticalformulationsbyusingmultivariatetechnique AT muvvalasudhakar validatedspectrophotometricquantificationofaripiprazoleinpharmaceuticalformulationsbyusingmultivariatetechnique |