A Paradigm Shift in Primary Liver Cancer Therapy Utilizing Genomics, Molecular Biomarkers, and Artificial Intelligence
Primary liver cancer is the sixth most common cancer worldwide and the third leading cause of cancer-related death. Conventional therapies offer limited survival benefit despite improvements in locoregional liver-directed therapies, which highlights the underlying complexity of liver cancers. This r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/10/2791 |
| _version_ | 1797600721120526336 |
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| author | James Moroney Juan Trivella Ben George Sarah B. White |
| author_facet | James Moroney Juan Trivella Ben George Sarah B. White |
| author_sort | James Moroney |
| collection | DOAJ |
| description | Primary liver cancer is the sixth most common cancer worldwide and the third leading cause of cancer-related death. Conventional therapies offer limited survival benefit despite improvements in locoregional liver-directed therapies, which highlights the underlying complexity of liver cancers. This review explores the latest research in primary liver cancer therapies, focusing on developments in genomics, molecular biomarkers, and artificial intelligence. Attention is also given to ongoing research and future directions of immunotherapy and locoregional therapies of primary liver cancers. |
| first_indexed | 2024-03-11T03:51:54Z |
| format | Article |
| id | doaj.art-9a914c8e30414db8956da34cc97e2289 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T03:51:54Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9a914c8e30414db8956da34cc97e22892023-11-18T00:49:03ZengMDPI AGCancers2072-66942023-05-011510279110.3390/cancers15102791A Paradigm Shift in Primary Liver Cancer Therapy Utilizing Genomics, Molecular Biomarkers, and Artificial IntelligenceJames Moroney0Juan Trivella1Ben George2Sarah B. White3Division of Vascular and Interventional Radiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI 53226, USADivision of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USADivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USADivision of Vascular and Interventional Radiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI 53226, USAPrimary liver cancer is the sixth most common cancer worldwide and the third leading cause of cancer-related death. Conventional therapies offer limited survival benefit despite improvements in locoregional liver-directed therapies, which highlights the underlying complexity of liver cancers. This review explores the latest research in primary liver cancer therapies, focusing on developments in genomics, molecular biomarkers, and artificial intelligence. Attention is also given to ongoing research and future directions of immunotherapy and locoregional therapies of primary liver cancers.https://www.mdpi.com/2072-6694/15/10/2791hepatocellular carcinomacholangiocarcinomaliver-directed therapiesmolecular biomarkersgenomicsartificial intelligence |
| spellingShingle | James Moroney Juan Trivella Ben George Sarah B. White A Paradigm Shift in Primary Liver Cancer Therapy Utilizing Genomics, Molecular Biomarkers, and Artificial Intelligence Cancers hepatocellular carcinoma cholangiocarcinoma liver-directed therapies molecular biomarkers genomics artificial intelligence |
| title | A Paradigm Shift in Primary Liver Cancer Therapy Utilizing Genomics, Molecular Biomarkers, and Artificial Intelligence |
| title_full | A Paradigm Shift in Primary Liver Cancer Therapy Utilizing Genomics, Molecular Biomarkers, and Artificial Intelligence |
| title_fullStr | A Paradigm Shift in Primary Liver Cancer Therapy Utilizing Genomics, Molecular Biomarkers, and Artificial Intelligence |
| title_full_unstemmed | A Paradigm Shift in Primary Liver Cancer Therapy Utilizing Genomics, Molecular Biomarkers, and Artificial Intelligence |
| title_short | A Paradigm Shift in Primary Liver Cancer Therapy Utilizing Genomics, Molecular Biomarkers, and Artificial Intelligence |
| title_sort | paradigm shift in primary liver cancer therapy utilizing genomics molecular biomarkers and artificial intelligence |
| topic | hepatocellular carcinoma cholangiocarcinoma liver-directed therapies molecular biomarkers genomics artificial intelligence |
| url | https://www.mdpi.com/2072-6694/15/10/2791 |
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