How to reset metabolic setpoint in obesity management
The metabolic setpoint theory is based upon the premise that there is a barohomeostatic mechanism in humans which maintains weight within a predetermined range. This is viewed as an obstacle to weight loss, but can also be considered an opportunity to reset the barometabolic setpoint. This expert c...
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| Format: | Article |
| Language: | English |
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Pakistan Medical Association
2022-03-01
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| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/6683 |
| _version_ | 1797820801409351680 |
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| author | Sanjay Kalra Saurabh Arora Nitin Kapoor |
| author_facet | Sanjay Kalra Saurabh Arora Nitin Kapoor |
| author_sort | Sanjay Kalra |
| collection | DOAJ |
| description |
The metabolic setpoint theory is based upon the premise that there is a barohomeostatic mechanism in humans which maintains weight within a predetermined range. This is viewed as an obstacle to weight loss, but can also be considered an opportunity to reset the barometabolic setpoint. This expert clinical opinion piece shares pragmatic suggestions on how to achieve this. Initiating with monotherapy, titrating dosage gradually, inter-changing treatment if needed, troubleshooting where necessary and intensifying slowly to combination therapy help reset the barometabolic homeostatic range.
Keywords: Barocrinology, GLP1RA, Intensive behavioural therapy, Liraglutide, Overweight, Obesity, Semaglutide.
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| first_indexed | 2024-03-13T09:43:42Z |
| format | Article |
| id | doaj.art-9a9188ceee36406ea3c96e97c30c7dfa |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-13T09:43:42Z |
| publishDate | 2022-03-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-9a9188ceee36406ea3c96e97c30c7dfa2023-05-25T04:22:33ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822022-03-0172210.47391/JPMA.22-37How to reset metabolic setpoint in obesity managementSanjay Kalra 0Saurabh Arora1Nitin Kapoor 2Department of Endocrinology, Bharti Hospital, Karnal, IndiaDepartment of Endocrinology, Dayanand Medical College and Hospital, Ludhiana, India.Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore (TN) -632004, India, and Non Communicable Disease Unit, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia The metabolic setpoint theory is based upon the premise that there is a barohomeostatic mechanism in humans which maintains weight within a predetermined range. This is viewed as an obstacle to weight loss, but can also be considered an opportunity to reset the barometabolic setpoint. This expert clinical opinion piece shares pragmatic suggestions on how to achieve this. Initiating with monotherapy, titrating dosage gradually, inter-changing treatment if needed, troubleshooting where necessary and intensifying slowly to combination therapy help reset the barometabolic homeostatic range. Keywords: Barocrinology, GLP1RA, Intensive behavioural therapy, Liraglutide, Overweight, Obesity, Semaglutide. https://www.ojs.jpma.org.pk/index.php/public_html/article/view/6683 |
| spellingShingle | Sanjay Kalra Saurabh Arora Nitin Kapoor How to reset metabolic setpoint in obesity management Journal of the Pakistan Medical Association |
| title | How to reset metabolic setpoint in obesity management |
| title_full | How to reset metabolic setpoint in obesity management |
| title_fullStr | How to reset metabolic setpoint in obesity management |
| title_full_unstemmed | How to reset metabolic setpoint in obesity management |
| title_short | How to reset metabolic setpoint in obesity management |
| title_sort | how to reset metabolic setpoint in obesity management |
| url | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/6683 |
| work_keys_str_mv | AT sanjaykalra howtoresetmetabolicsetpointinobesitymanagement AT saurabharora howtoresetmetabolicsetpointinobesitymanagement AT nitinkapoor howtoresetmetabolicsetpointinobesitymanagement |