NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy
Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by transient denervation. Aiming to de...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/7/1575 |
| _version_ | 1797563956108197888 |
|---|---|
| author | Sara Marmolejo-Martínez-Artesero David Romeo-Guitart Laura Mañas-García Esther Barreiro Caty Casas |
| author_facet | Sara Marmolejo-Martínez-Artesero David Romeo-Guitart Laura Mañas-García Esther Barreiro Caty Casas |
| author_sort | Sara Marmolejo-Martínez-Artesero |
| collection | DOAJ |
| description | Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by transient denervation. Aiming to decipher whether NeuroHeal has a direct role in muscle biology, we used herein different models of muscle atrophy: one caused by chronic denervation, another caused by hindlimb immobilization, and lastly, an in vitro model of myotube atrophy with Tumor Necrosis Factor-α (TNFα). In all these models, we observed that NeuroHeal reduced muscle atrophy and that SIRT1 activation seems to be required for that. The treatment downregulated some critical markers of protein degradation: Muscle Ring Finger 1 (MuRF1), K48 poly-Ub chains, and p62/SQSTM1. Moreover, it seems to restore the autophagy flux associated with denervation. Hence, we envisage a prospective use of NeuroHeal at clinics for different myopathies. |
| first_indexed | 2024-03-10T18:50:33Z |
| format | Article |
| id | doaj.art-9a91bafc3ff648608e576bfb1892a1d2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T18:50:33Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9a91bafc3ff648608e576bfb1892a1d22023-11-20T05:12:06ZengMDPI AGCells2073-44092020-06-0197157510.3390/cells9071575NeuroHeal Reduces Muscle Atrophy and Modulates Associated AutophagySara Marmolejo-Martínez-Artesero0David Romeo-Guitart1Laura Mañas-García2Esther Barreiro3Caty Casas4Institut de Neurociències (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona (UAB), Bellaterra, 08193 Barcelona, SpainInstitut de Neurociències (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona (UAB), Bellaterra, 08193 Barcelona, SpainPulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona Biomedical Research Park (PRBB), 08003 Barcelona, SpainPulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona Biomedical Research Park (PRBB), 08003 Barcelona, SpainInstitut de Neurociències (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona (UAB), Bellaterra, 08193 Barcelona, SpainMuscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by transient denervation. Aiming to decipher whether NeuroHeal has a direct role in muscle biology, we used herein different models of muscle atrophy: one caused by chronic denervation, another caused by hindlimb immobilization, and lastly, an in vitro model of myotube atrophy with Tumor Necrosis Factor-α (TNFα). In all these models, we observed that NeuroHeal reduced muscle atrophy and that SIRT1 activation seems to be required for that. The treatment downregulated some critical markers of protein degradation: Muscle Ring Finger 1 (MuRF1), K48 poly-Ub chains, and p62/SQSTM1. Moreover, it seems to restore the autophagy flux associated with denervation. Hence, we envisage a prospective use of NeuroHeal at clinics for different myopathies.https://www.mdpi.com/2073-4409/9/7/1575NeuroHealskeletal muscle atrophysirtuin 1autophagyproteasome |
| spellingShingle | Sara Marmolejo-Martínez-Artesero David Romeo-Guitart Laura Mañas-García Esther Barreiro Caty Casas NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy Cells NeuroHeal skeletal muscle atrophy sirtuin 1 autophagy proteasome |
| title | NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy |
| title_full | NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy |
| title_fullStr | NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy |
| title_full_unstemmed | NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy |
| title_short | NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy |
| title_sort | neuroheal reduces muscle atrophy and modulates associated autophagy |
| topic | NeuroHeal skeletal muscle atrophy sirtuin 1 autophagy proteasome |
| url | https://www.mdpi.com/2073-4409/9/7/1575 |
| work_keys_str_mv | AT saramarmolejomartinezartesero neurohealreducesmuscleatrophyandmodulatesassociatedautophagy AT davidromeoguitart neurohealreducesmuscleatrophyandmodulatesassociatedautophagy AT lauramanasgarcia neurohealreducesmuscleatrophyandmodulatesassociatedautophagy AT estherbarreiro neurohealreducesmuscleatrophyandmodulatesassociatedautophagy AT catycasas neurohealreducesmuscleatrophyandmodulatesassociatedautophagy |