Gloss measurement in detection of surface quality of pharmaceutical tablets: a case study of screening of genuine and counterfeit antimalaria tablets
Abstract Background The surface quality of pharmaceutical tablets plays an important role, especially in the drug release of a tablet and hence affects the bioavailability of the drug. Furthermore, important tablet’s properties such as coating uniformity and mechanical integrity that can be pr...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2017-06-01
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| Series: | Journal of the European Optical Society-Rapid Publications |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41476-017-0046-8 |
| _version_ | 1818998509775355904 |
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| author | Prince Bawuah Pertti Pääkkönen Kai-Erik Peiponen |
| author_facet | Prince Bawuah Pertti Pääkkönen Kai-Erik Peiponen |
| author_sort | Prince Bawuah |
| collection | DOAJ |
| description | Abstract Background The surface quality of pharmaceutical tablets plays an important role, especially in the drug release of a tablet and hence affects the bioavailability of the drug. Furthermore, important tablet’s properties such as coating uniformity and mechanical integrity that can be predicted based on the known surface properties manifest the inevitable link between a tablet’s surface property (e.g. Gloss, average surface roughness) and its efficacy. Methods In this article, laboratory based and handheld glossmeters as well as an optical profilometer were utilized for the detection of the surface properties of commercially available pharmaceutical tablets. Results As a case study, we measured the surface properties of authentic and counterfeit antimalarial tablets. Clear differences between authentic and fake tablets were detected based on the measured average surface roughness and gloss values of the tablet samples. Conclusions It is worth mentioning that this is the first time we have utilized both glossmeters for the purpose of surface quality investigation of real pharmaceutical tablets. It is therefore suggested that the handheld glossmeter is a useful device for quick inspection of tablet’s surface quality both in the production environments as well as for field screening of fake tablets. |
| first_indexed | 2024-12-20T22:02:40Z |
| format | Article |
| id | doaj.art-9a9380024b9b421ba93782ea8b705e06 |
| institution | Directory Open Access Journal |
| issn | 1990-2573 |
| language | English |
| last_indexed | 2024-12-20T22:02:40Z |
| publishDate | 2017-06-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Journal of the European Optical Society-Rapid Publications |
| spelling | doaj.art-9a9380024b9b421ba93782ea8b705e062022-12-21T19:25:19ZengEDP SciencesJournal of the European Optical Society-Rapid Publications1990-25732017-06-011311710.1186/s41476-017-0046-8Gloss measurement in detection of surface quality of pharmaceutical tablets: a case study of screening of genuine and counterfeit antimalaria tabletsPrince Bawuah0Pertti Pääkkönen1Kai-Erik Peiponen2Department of Physics and Mathematics, University of Eastern FinlandDepartment of Physics and Mathematics, University of Eastern FinlandDepartment of Physics and Mathematics, University of Eastern FinlandAbstract Background The surface quality of pharmaceutical tablets plays an important role, especially in the drug release of a tablet and hence affects the bioavailability of the drug. Furthermore, important tablet’s properties such as coating uniformity and mechanical integrity that can be predicted based on the known surface properties manifest the inevitable link between a tablet’s surface property (e.g. Gloss, average surface roughness) and its efficacy. Methods In this article, laboratory based and handheld glossmeters as well as an optical profilometer were utilized for the detection of the surface properties of commercially available pharmaceutical tablets. Results As a case study, we measured the surface properties of authentic and counterfeit antimalarial tablets. Clear differences between authentic and fake tablets were detected based on the measured average surface roughness and gloss values of the tablet samples. Conclusions It is worth mentioning that this is the first time we have utilized both glossmeters for the purpose of surface quality investigation of real pharmaceutical tablets. It is therefore suggested that the handheld glossmeter is a useful device for quick inspection of tablet’s surface quality both in the production environments as well as for field screening of fake tablets.http://link.springer.com/article/10.1186/s41476-017-0046-8GlossSurface roughnessQuality screeningAntimalaria tabletsArtemetherLumefantrine |
| spellingShingle | Prince Bawuah Pertti Pääkkönen Kai-Erik Peiponen Gloss measurement in detection of surface quality of pharmaceutical tablets: a case study of screening of genuine and counterfeit antimalaria tablets Journal of the European Optical Society-Rapid Publications Gloss Surface roughness Quality screening Antimalaria tablets Artemether Lumefantrine |
| title | Gloss measurement in detection of surface quality of pharmaceutical tablets: a case study of screening of genuine and counterfeit antimalaria tablets |
| title_full | Gloss measurement in detection of surface quality of pharmaceutical tablets: a case study of screening of genuine and counterfeit antimalaria tablets |
| title_fullStr | Gloss measurement in detection of surface quality of pharmaceutical tablets: a case study of screening of genuine and counterfeit antimalaria tablets |
| title_full_unstemmed | Gloss measurement in detection of surface quality of pharmaceutical tablets: a case study of screening of genuine and counterfeit antimalaria tablets |
| title_short | Gloss measurement in detection of surface quality of pharmaceutical tablets: a case study of screening of genuine and counterfeit antimalaria tablets |
| title_sort | gloss measurement in detection of surface quality of pharmaceutical tablets a case study of screening of genuine and counterfeit antimalaria tablets |
| topic | Gloss Surface roughness Quality screening Antimalaria tablets Artemether Lumefantrine |
| url | http://link.springer.com/article/10.1186/s41476-017-0046-8 |
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