Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials
Objective: To conduct a meta-analysis of randomized controlled trials (RCTs) on the effects of atropine eye drop in slowing myopia progression. Methods: A systematic search of relevant articles was done through a computerized search on PubMed, Medline, Cochrane Library, and Google Scholar on June 16...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=11;spage=6668;epage=6677;aulast=Kumari |
| _version_ | 1797954876403089408 |
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| author | Shalini Kumari Raj Anand Shashank Tripathi Rajesh C Mishra Simant Kumar Jha |
| author_facet | Shalini Kumari Raj Anand Shashank Tripathi Rajesh C Mishra Simant Kumar Jha |
| author_sort | Shalini Kumari |
| collection | DOAJ |
| description | Objective: To conduct a meta-analysis of randomized controlled trials (RCTs) on the effects of atropine eye drop in slowing myopia progression. Methods: A systematic search of relevant articles was done through a computerized search on PubMed, Medline, Cochrane Library, and Google Scholar on June 16, 2022. A supplementary search was done on ClinicalTrials.gov on the same date. After thorough search and analysis, seven relevant RCTs, double-masked with atropine eye drop as intervention arm and placebo as control arm, were selected for meta-analysis. Jadad scoring was used to evaluate the quality of RCTs. The outcome measurements included in the present meta-analysis are mean changes in the spherical equivalent (SE) of myopic error, and mean changes in axial length (AL) during the study period. Result: Pooled summary effect size, calculated by random effect model, for SE of myopia progression was 1.08 with 95% confidence interval (CI) (0.31–1.86) which was statistically significant (P-value = 0.006). Pooled summary effect size, calculated by random effect model, for axial length was − 0.89 with 95% CI (−1.48 to − 0.30) which was statistically significant (P-value = 0.003). Conclusion: In summary, atropine was demonstrated to be effective in controlling myopia progression in children. Both outcome measures, mean SE changes and mean AL elongation responded to atropine intervention compared to placebo. |
| first_indexed | 2024-04-10T23:25:28Z |
| format | Article |
| id | doaj.art-9a93faa052064824aedadf903e4e56c1 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-04-10T23:25:28Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-9a93faa052064824aedadf903e4e56c12023-01-12T12:42:32ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632022-01-0111116668667710.4103/jfmpc.jfmpc_1339_22Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trialsShalini KumariRaj AnandShashank TripathiRajesh C MishraSimant Kumar JhaObjective: To conduct a meta-analysis of randomized controlled trials (RCTs) on the effects of atropine eye drop in slowing myopia progression. Methods: A systematic search of relevant articles was done through a computerized search on PubMed, Medline, Cochrane Library, and Google Scholar on June 16, 2022. A supplementary search was done on ClinicalTrials.gov on the same date. After thorough search and analysis, seven relevant RCTs, double-masked with atropine eye drop as intervention arm and placebo as control arm, were selected for meta-analysis. Jadad scoring was used to evaluate the quality of RCTs. The outcome measurements included in the present meta-analysis are mean changes in the spherical equivalent (SE) of myopic error, and mean changes in axial length (AL) during the study period. Result: Pooled summary effect size, calculated by random effect model, for SE of myopia progression was 1.08 with 95% confidence interval (CI) (0.31–1.86) which was statistically significant (P-value = 0.006). Pooled summary effect size, calculated by random effect model, for axial length was − 0.89 with 95% CI (−1.48 to − 0.30) which was statistically significant (P-value = 0.003). Conclusion: In summary, atropine was demonstrated to be effective in controlling myopia progression in children. Both outcome measures, mean SE changes and mean AL elongation responded to atropine intervention compared to placebo.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=11;spage=6668;epage=6677;aulast=Kumariatropinechildrenmyopiaprogressionrefractive errorvision |
| spellingShingle | Shalini Kumari Raj Anand Shashank Tripathi Rajesh C Mishra Simant Kumar Jha Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials Journal of Family Medicine and Primary Care atropine children myopia progression refractive error vision |
| title | Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials |
| title_full | Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials |
| title_fullStr | Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials |
| title_full_unstemmed | Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials |
| title_short | Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials |
| title_sort | efficacy of atropine for myopia control in children a meta analysis of randomized controlled trials |
| topic | atropine children myopia progression refractive error vision |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=11;spage=6668;epage=6677;aulast=Kumari |
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