HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies
Transcription is a crucial step in the life cycle of the human immunodeficiency virus type 1 (HIV 1) and is primarily involved in the maintenance of viral latency. Both viral and cellular transcription factors, including transcriptional activators, suppressor proteins and epigenetic factors, are inv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-04-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/4/933 |
| _version_ | 1818515872390578176 |
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| author | Kaori Asamitsu Koh Fujinaga Takashi Okamoto |
| author_facet | Kaori Asamitsu Koh Fujinaga Takashi Okamoto |
| author_sort | Kaori Asamitsu |
| collection | DOAJ |
| description | Transcription is a crucial step in the life cycle of the human immunodeficiency virus type 1 (HIV 1) and is primarily involved in the maintenance of viral latency. Both viral and cellular transcription factors, including transcriptional activators, suppressor proteins and epigenetic factors, are involved in HIV transcription from the proviral DNA integrated within the host cell genome. Among them, the virus-encoded transcriptional activator Tat is the master regulator of HIV transcription. Interestingly, unlike other known transcriptional activators, Tat primarily activates transcriptional elongation and initiation by interacting with the cellular positive transcriptional elongation factor b (P-TEFb). In this review, we describe the molecular mechanism underlying how Tat activates viral transcription through interaction with P-TEFb. We propose a novel therapeutic strategy against HIV replication through blocking Tat action. |
| first_indexed | 2024-12-11T00:34:31Z |
| format | Article |
| id | doaj.art-9a94a12a186e41f28fee7af40698bd75 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T00:34:31Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9a94a12a186e41f28fee7af40698bd752022-12-22T01:27:13ZengMDPI AGMolecules1420-30492018-04-0123493310.3390/molecules23040933molecules23040933HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV TherapiesKaori Asamitsu0Koh Fujinaga1Takashi Okamoto2Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, JapanDepartment of Medicine, Microbiology and Immunology, University of California, San Francisco, CA 94143-0703, USADepartment of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, JapanTranscription is a crucial step in the life cycle of the human immunodeficiency virus type 1 (HIV 1) and is primarily involved in the maintenance of viral latency. Both viral and cellular transcription factors, including transcriptional activators, suppressor proteins and epigenetic factors, are involved in HIV transcription from the proviral DNA integrated within the host cell genome. Among them, the virus-encoded transcriptional activator Tat is the master regulator of HIV transcription. Interestingly, unlike other known transcriptional activators, Tat primarily activates transcriptional elongation and initiation by interacting with the cellular positive transcriptional elongation factor b (P-TEFb). In this review, we describe the molecular mechanism underlying how Tat activates viral transcription through interaction with P-TEFb. We propose a novel therapeutic strategy against HIV replication through blocking Tat action.http://www.mdpi.com/1420-3049/23/4/933HIV transcriptionP-TEFbcyclin T1CDK9TatHEXIM1 |
| spellingShingle | Kaori Asamitsu Koh Fujinaga Takashi Okamoto HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies Molecules HIV transcription P-TEFb cyclin T1 CDK9 Tat HEXIM1 |
| title | HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies |
| title_full | HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies |
| title_fullStr | HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies |
| title_full_unstemmed | HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies |
| title_short | HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies |
| title_sort | hiv tat p tefb interaction a potential target for novel anti hiv therapies |
| topic | HIV transcription P-TEFb cyclin T1 CDK9 Tat HEXIM1 |
| url | http://www.mdpi.com/1420-3049/23/4/933 |
| work_keys_str_mv | AT kaoriasamitsu hivtatptefbinteractionapotentialtargetfornovelantihivtherapies AT kohfujinaga hivtatptefbinteractionapotentialtargetfornovelantihivtherapies AT takashiokamoto hivtatptefbinteractionapotentialtargetfornovelantihivtherapies |