Elevations in Serum Dickkopf-1 and Disease Progression in Community-Dwelling Older Adults With Mild Cognitive Impairment and Mild-to-Moderate Alzheimer’s Disease

Elevations in Serum Dickkopf-1 and Disease Progression in Community-Dwelling Older Adults With Mild Cognitive Impairment and Mild-to-Moderate Alzheimer’s Disease

Background: Disruption of Wnt signaling has been implicated in dysfunctional synaptic plasticity, the degree of which correlates with Alzheimer’s disease severity. We sought to examine whether serum levels of Dickkopf-1 (Dkk-1), a Wnt antagonist, are associated with global disease progression in old...

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Bibliographic Details
Main Authors: Laura Tay, Bernard Leung, Audrey Yeo, Mark Chan, Wee Shiong Lim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
Dickkopf-1
mild cognitive impairment
Alzheimer’s disease
disease progression
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00278/full

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