Peptidic defective interfering gene nanoparticles against Omicron, Delta SARS-CoV-2 variants and influenza A virus in vivo

Peptidic defective interfering gene nanoparticles against Omicron, Delta SARS-CoV-2 variants and influenza A virus in vivo

Abstract Defective interfering genes (DIGs) are short viral genomes and interfere with wild-type viral replication. Here, we demonstrate that the new designed SARS-CoV-2 DIG (CD3600) can significantly inhibit the replication of SARS-CoV-2 including Alpha, Delta, Kappa and Omicron variants in human H...

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Bibliographic Details
Main Authors: Hanjun Zhao, Chuyuan Zhang, Hoiyan Lam, Xinjie Meng, Zheng Peng, Man Lung Yeung, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Kwok-Yung Yuen
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-01138-0

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