Fibrin as a Multipurpose Physiological Platform for Bone Tissue Engineering and Targeted Delivery of Bioactive Compounds
Although bone graft is still considered as the gold standard method, bone tissue engineering offers promising alternatives designed to mimic the extracellular matrix (ECM) and to guide bone regeneration process. In this attempt, due to their similarity to the ECM and their low toxicity/immunogenicit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/11/556 |
| _version_ | 1828153138182356992 |
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| author | Bruno Bujoli Jean-Claude Scimeca Elise Verron |
| author_facet | Bruno Bujoli Jean-Claude Scimeca Elise Verron |
| author_sort | Bruno Bujoli |
| collection | DOAJ |
| description | Although bone graft is still considered as the gold standard method, bone tissue engineering offers promising alternatives designed to mimic the extracellular matrix (ECM) and to guide bone regeneration process. In this attempt, due to their similarity to the ECM and their low toxicity/immunogenicity properties, growing attention is paid to natural polymers. In particular, considering the early critical role of fracture hematoma for bone healing, fibrin, which constitutes blood clot, is a candidate of choice. Indeed, in addition to its physiological roles in bone healing cascade, fibrin biochemical characteristics make it suitable to be used as a multipurpose platform for bioactive agents’ delivery. Thus, taking advantage of these key assets, researchers and clinicians have the opportunity to develop composite systems that might further improve bone tissue reconstruction, and more generally prevent/treat skeletal disorders. |
| first_indexed | 2024-04-11T22:21:11Z |
| format | Article |
| id | doaj.art-9a99888ad095484c82fd344afc31e14e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T22:21:11Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-9a99888ad095484c82fd344afc31e14e2022-12-22T04:00:08ZengMDPI AGPharmaceutics1999-49232019-10-01111155610.3390/pharmaceutics11110556pharmaceutics11110556Fibrin as a Multipurpose Physiological Platform for Bone Tissue Engineering and Targeted Delivery of Bioactive CompoundsBruno Bujoli0Jean-Claude Scimeca1Elise Verron2Chemical and Interdisciplinarity, Synthesis, Analysis, Modelisation, CEISAM UMR CNRS 6230, University of Nantes, 44300 Nantes, FranceUniversité Côte d’Azur, CNRS, Inserm, iBV, 06107 Nice, FranceChemical and Interdisciplinarity, Synthesis, Analysis, Modelisation, CEISAM UMR CNRS 6230, University of Nantes, 44300 Nantes, FranceAlthough bone graft is still considered as the gold standard method, bone tissue engineering offers promising alternatives designed to mimic the extracellular matrix (ECM) and to guide bone regeneration process. In this attempt, due to their similarity to the ECM and their low toxicity/immunogenicity properties, growing attention is paid to natural polymers. In particular, considering the early critical role of fracture hematoma for bone healing, fibrin, which constitutes blood clot, is a candidate of choice. Indeed, in addition to its physiological roles in bone healing cascade, fibrin biochemical characteristics make it suitable to be used as a multipurpose platform for bioactive agents’ delivery. Thus, taking advantage of these key assets, researchers and clinicians have the opportunity to develop composite systems that might further improve bone tissue reconstruction, and more generally prevent/treat skeletal disorders.https://www.mdpi.com/1999-4923/11/11/556fibrinnatural polymersbiomaterialsdelivery systemsbone regeneration |
| spellingShingle | Bruno Bujoli Jean-Claude Scimeca Elise Verron Fibrin as a Multipurpose Physiological Platform for Bone Tissue Engineering and Targeted Delivery of Bioactive Compounds Pharmaceutics fibrin natural polymers biomaterials delivery systems bone regeneration |
| title | Fibrin as a Multipurpose Physiological Platform for Bone Tissue Engineering and Targeted Delivery of Bioactive Compounds |
| title_full | Fibrin as a Multipurpose Physiological Platform for Bone Tissue Engineering and Targeted Delivery of Bioactive Compounds |
| title_fullStr | Fibrin as a Multipurpose Physiological Platform for Bone Tissue Engineering and Targeted Delivery of Bioactive Compounds |
| title_full_unstemmed | Fibrin as a Multipurpose Physiological Platform for Bone Tissue Engineering and Targeted Delivery of Bioactive Compounds |
| title_short | Fibrin as a Multipurpose Physiological Platform for Bone Tissue Engineering and Targeted Delivery of Bioactive Compounds |
| title_sort | fibrin as a multipurpose physiological platform for bone tissue engineering and targeted delivery of bioactive compounds |
| topic | fibrin natural polymers biomaterials delivery systems bone regeneration |
| url | https://www.mdpi.com/1999-4923/11/11/556 |
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