Expression of pro-inflammatory cytokine and caspase genes promotes neuronal apoptosis in pontine reticular formation after spinal cord transection

Expression of pro-inflammatory cytokine and caspase genes promotes neuronal apoptosis in pontine reticular formation after spinal cord transection

We identified apoptotic neurons in pontine reticular formation (PRF), the origin of pontine reticulospinal fibers, in adult Sprague–Dawley rats after complete spinal cord transection (SCT) at T8 level. SCT also increased the expression in PRF of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β,...

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Bibliographic Details
Main Authors: Kay L.H Wu, Samuel H.H Chan, Yung-Mei Chao, Julie Y.H Chan
Format: Article
Language:English
Published: Elsevier 2003-10-01
Series:Neurobiology of Disease
Subjects:
Apoptosis
Proinflammatory genes
Cytokines
Caspases
Pontine reticular formation
Spinal cord injury
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103000780

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