Safety and Efficacy of Irreversible Electroporation Combined with Neoadjuvant Chemotherapy for Locally Advanced Pancreatic Cancer: A Meta-analysis
Objective To evaluate the safety and efficacy of irreversible electroporation (IRE) combined with neoadjuvant chemotherapy in patients with locally advanced pancreatic cancer. Methods We searched PubMed, Embase, Cochrane Library, Web of Science, China Biomedical Literature Database, CNKI, Wanfang, a...
| Main Authors: | , , , , , , , , , |
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Magazine House of Cancer Research on Prevention and Treatment
2022-11-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.22.0367 |
| _version_ | 1797819831290953728 |
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| author | ZHAO Baoyin LIANG Zhaojun ZHANG Lixia CHEN Shun JIA Dong WU Zhaohui LI Bin WANG Junke MA Jun YU Xiaohui |
| author_facet | ZHAO Baoyin LIANG Zhaojun ZHANG Lixia CHEN Shun JIA Dong WU Zhaohui LI Bin WANG Junke MA Jun YU Xiaohui |
| author_sort | ZHAO Baoyin |
| collection | DOAJ |
| description | Objective To evaluate the safety and efficacy of irreversible electroporation (IRE) combined with neoadjuvant chemotherapy in patients with locally advanced pancreatic cancer. Methods We searched PubMed, Embase, Cochrane Library, Web of Science, China Biomedical Literature Database, CNKI, Wanfang, and VIP databases for articles dated from the establishment of each database to March 2022. Meta-analysis was performed using RevMan5.4 software. Results A total of 3970 patients with locally advanced pancreatic cancer were enrolled in eight studies, including one randomized controlled trial, four retrospective studies, and three prospective studies. The patients were divided into the combined therapy group with 344 patients and the chemotherapy-only group with 3626 patients. Meta-analysis showed that the overall survival of patients in the combined therapy group was significantly higher than that in the chemotherapy-only group (OR=4.52; 95%CI: 2.63-7.77; P < 0.00001). However, no significant difference existed in the disease control rate between the combined therapy group and the chemotherapy-only group (OR=0.58; 95%CI: 0.02-18.74; P=0.76). Moreover, no significant difference existed in the disease progression between the two groups (OR=0.49; 95%CI: 0.23-1.02; P=0.06). The combination of neoadjuvant chemotherapy and IRE had no significant effect on the incidence of adverse reactions of gastrointestinal reaction (OR=0.37; 95%CI: 0.10-1.34; P=0.13) and bone marrow suppression (OR=0.61; 95%CI: 0.26-1.40; P=0.24). Conclusion IRE combined with neoadjuvant chemotherapy can remarkably improve the prognosis of patients with locally advanced pancreatic cancer, and significantly prolong the overall survival. |
| first_indexed | 2024-03-13T09:29:21Z |
| format | Article |
| id | doaj.art-9a9d2eea0a934837b8378d55bd67caae |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-03-13T09:29:21Z |
| publishDate | 2022-11-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-9a9d2eea0a934837b8378d55bd67caae2023-05-26T04:23:49ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782022-11-0149111139114510.3971/j.issn.1000-8578.2022.22.03678578.2022.22.0367Safety and Efficacy of Irreversible Electroporation Combined with Neoadjuvant Chemotherapy for Locally Advanced Pancreatic Cancer: A Meta-analysisZHAO Baoyin0LIANG Zhaojun1ZHANG Lixia2CHEN Shun3JIA Dong4WU Zhaohui5LI Bin6WANG Junke7MA Jun8YU Xiaohui9The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, ChinaDepartment of Gastroenterology, 940th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Lanzhou 730050, ChinaDepartment of Gastroenterology, 940th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Lanzhou 730050, ChinaDepartment of Gastroenterology, 940th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Lanzhou 730050, ChinaThe First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, ChinaThe First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, ChinaDepartment of Gastroenterology, 940th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Lanzhou 730050, ChinaDepartment of Gastroenterology, 940th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Lanzhou 730050, ChinaLaboratory of Basic Medicine, 940th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Gansu Key Laboratory of Stem Cells and Genetic Drugs, Lanzhou 730050, ChinaDepartment of Gastroenterology, 940th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Lanzhou 730050, ChinaObjective To evaluate the safety and efficacy of irreversible electroporation (IRE) combined with neoadjuvant chemotherapy in patients with locally advanced pancreatic cancer. Methods We searched PubMed, Embase, Cochrane Library, Web of Science, China Biomedical Literature Database, CNKI, Wanfang, and VIP databases for articles dated from the establishment of each database to March 2022. Meta-analysis was performed using RevMan5.4 software. Results A total of 3970 patients with locally advanced pancreatic cancer were enrolled in eight studies, including one randomized controlled trial, four retrospective studies, and three prospective studies. The patients were divided into the combined therapy group with 344 patients and the chemotherapy-only group with 3626 patients. Meta-analysis showed that the overall survival of patients in the combined therapy group was significantly higher than that in the chemotherapy-only group (OR=4.52; 95%CI: 2.63-7.77; P < 0.00001). However, no significant difference existed in the disease control rate between the combined therapy group and the chemotherapy-only group (OR=0.58; 95%CI: 0.02-18.74; P=0.76). Moreover, no significant difference existed in the disease progression between the two groups (OR=0.49; 95%CI: 0.23-1.02; P=0.06). The combination of neoadjuvant chemotherapy and IRE had no significant effect on the incidence of adverse reactions of gastrointestinal reaction (OR=0.37; 95%CI: 0.10-1.34; P=0.13) and bone marrow suppression (OR=0.61; 95%CI: 0.26-1.40; P=0.24). Conclusion IRE combined with neoadjuvant chemotherapy can remarkably improve the prognosis of patients with locally advanced pancreatic cancer, and significantly prolong the overall survival.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.22.0367irreversible electroporationneoadjuvant chemotherapypancreatic cancersafetyefficacymeta-analysis |
| spellingShingle | ZHAO Baoyin LIANG Zhaojun ZHANG Lixia CHEN Shun JIA Dong WU Zhaohui LI Bin WANG Junke MA Jun YU Xiaohui Safety and Efficacy of Irreversible Electroporation Combined with Neoadjuvant Chemotherapy for Locally Advanced Pancreatic Cancer: A Meta-analysis Zhongliu Fangzhi Yanjiu irreversible electroporation neoadjuvant chemotherapy pancreatic cancer safety efficacy meta-analysis |
| title | Safety and Efficacy of Irreversible Electroporation Combined with Neoadjuvant Chemotherapy for Locally Advanced Pancreatic Cancer: A Meta-analysis |
| title_full | Safety and Efficacy of Irreversible Electroporation Combined with Neoadjuvant Chemotherapy for Locally Advanced Pancreatic Cancer: A Meta-analysis |
| title_fullStr | Safety and Efficacy of Irreversible Electroporation Combined with Neoadjuvant Chemotherapy for Locally Advanced Pancreatic Cancer: A Meta-analysis |
| title_full_unstemmed | Safety and Efficacy of Irreversible Electroporation Combined with Neoadjuvant Chemotherapy for Locally Advanced Pancreatic Cancer: A Meta-analysis |
| title_short | Safety and Efficacy of Irreversible Electroporation Combined with Neoadjuvant Chemotherapy for Locally Advanced Pancreatic Cancer: A Meta-analysis |
| title_sort | safety and efficacy of irreversible electroporation combined with neoadjuvant chemotherapy for locally advanced pancreatic cancer a meta analysis |
| topic | irreversible electroporation neoadjuvant chemotherapy pancreatic cancer safety efficacy meta-analysis |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.22.0367 |
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