Risk factors of white matter hyperintensities in migraine patients
Abstract Background Migraine frequently is associated with White Matter Hyperintensities (WMHs). We aimed to assess the frequency of WMHs in migraine and to assess their risk factors. Methods This is cross-sectional study included 60 migraine patients of both genders, aged between 18 and 55 years. P...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-04-01
|
| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-022-02680-8 |
| _version_ | 1828370266249494528 |
|---|---|
| author | Jasem Yousef Al-Hashel Raed Alroughani Khaled Gad Lamiaa Al-Sarraf Samar Farouk Ahmed |
| author_facet | Jasem Yousef Al-Hashel Raed Alroughani Khaled Gad Lamiaa Al-Sarraf Samar Farouk Ahmed |
| author_sort | Jasem Yousef Al-Hashel |
| collection | DOAJ |
| description | Abstract Background Migraine frequently is associated with White Matter Hyperintensities (WMHs). We aimed to assess the frequency of WMHs in migraine and to assess their risk factors. Methods This is cross-sectional study included 60 migraine patients of both genders, aged between 18 and 55 years. Patients with vascular risk factors were excluded. We also included a matched healthy control group with no migraine. Demographic, clinical data, and serum level of homocysteine were recorded. All subjects underwent brain MRI (3 Tesla). Results The mean age was 38.65 years and most of our cohort were female (83.3). A total of 24 migraine patients (40%) had WMHs versus (10%) in the control group, (P < 0.013). Patients with WMHs were significantly older (43.50 + 8.71 versus. 35.92+ 8.55 years, P < 0.001), have a longer disease duration (14.54+ 7.76versus 8.58+ 6.89 years, P < 0.002), higher monthly migraine attacks (9.27+ 4. 31 versus 7.78 + 2.41 P < 0.020) and high serum homocysteine level (11.05+ 5.63 versus 6.36 + 6.27, P < 0.006) compared to those without WMHs. WMHs were more frequent in chronic migraine compared to episodic migraine (75% versus 34.6%; P < 0.030) and migraine with aura compared to those without aura (38.3% versus 29,2; P < 0.001). WMHs were mostly situated in the frontal lobes (83.4%), both hemispheres (70.8%), and mainly subcortically (83.3%). Conclusion Older age, longer disease duration, frequent attacks, and high serum homocysteine level are main the risk factors for WMHs in this cohort. The severity or duration of migraine attacks did not increase the frequency of WMHs. The number of WMHs was significantly higher in chronic compared to episodic migraineurs. |
| first_indexed | 2024-04-14T06:35:37Z |
| format | Article |
| id | doaj.art-9a9dcfb5572b4d89af6fb96c2702806e |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-14T06:35:37Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-9a9dcfb5572b4d89af6fb96c2702806e2022-12-22T02:07:28ZengBMCBMC Neurology1471-23772022-04-012211910.1186/s12883-022-02680-8Risk factors of white matter hyperintensities in migraine patientsJasem Yousef Al-Hashel0Raed Alroughani1Khaled Gad2Lamiaa Al-Sarraf3Samar Farouk Ahmed4Department of Neurology, Ibn Sina HospitalDivision of Neurology, Department of Medicine, Amiri HospitalMedical imaging Department, Ibn Sina HospitalMedical imaging Department, Ibn Sina HospitalDepartment of Neurology, Ibn Sina HospitalAbstract Background Migraine frequently is associated with White Matter Hyperintensities (WMHs). We aimed to assess the frequency of WMHs in migraine and to assess their risk factors. Methods This is cross-sectional study included 60 migraine patients of both genders, aged between 18 and 55 years. Patients with vascular risk factors were excluded. We also included a matched healthy control group with no migraine. Demographic, clinical data, and serum level of homocysteine were recorded. All subjects underwent brain MRI (3 Tesla). Results The mean age was 38.65 years and most of our cohort were female (83.3). A total of 24 migraine patients (40%) had WMHs versus (10%) in the control group, (P < 0.013). Patients with WMHs were significantly older (43.50 + 8.71 versus. 35.92+ 8.55 years, P < 0.001), have a longer disease duration (14.54+ 7.76versus 8.58+ 6.89 years, P < 0.002), higher monthly migraine attacks (9.27+ 4. 31 versus 7.78 + 2.41 P < 0.020) and high serum homocysteine level (11.05+ 5.63 versus 6.36 + 6.27, P < 0.006) compared to those without WMHs. WMHs were more frequent in chronic migraine compared to episodic migraine (75% versus 34.6%; P < 0.030) and migraine with aura compared to those without aura (38.3% versus 29,2; P < 0.001). WMHs were mostly situated in the frontal lobes (83.4%), both hemispheres (70.8%), and mainly subcortically (83.3%). Conclusion Older age, longer disease duration, frequent attacks, and high serum homocysteine level are main the risk factors for WMHs in this cohort. The severity or duration of migraine attacks did not increase the frequency of WMHs. The number of WMHs was significantly higher in chronic compared to episodic migraineurs.https://doi.org/10.1186/s12883-022-02680-8Migraine with auraMigraine without auraEpisodic migraineChronic migraineMagnetic resonance imagingHomocysteine |
| spellingShingle | Jasem Yousef Al-Hashel Raed Alroughani Khaled Gad Lamiaa Al-Sarraf Samar Farouk Ahmed Risk factors of white matter hyperintensities in migraine patients BMC Neurology Migraine with aura Migraine without aura Episodic migraine Chronic migraine Magnetic resonance imaging Homocysteine |
| title | Risk factors of white matter hyperintensities in migraine patients |
| title_full | Risk factors of white matter hyperintensities in migraine patients |
| title_fullStr | Risk factors of white matter hyperintensities in migraine patients |
| title_full_unstemmed | Risk factors of white matter hyperintensities in migraine patients |
| title_short | Risk factors of white matter hyperintensities in migraine patients |
| title_sort | risk factors of white matter hyperintensities in migraine patients |
| topic | Migraine with aura Migraine without aura Episodic migraine Chronic migraine Magnetic resonance imaging Homocysteine |
| url | https://doi.org/10.1186/s12883-022-02680-8 |
| work_keys_str_mv | AT jasemyousefalhashel riskfactorsofwhitematterhyperintensitiesinmigrainepatients AT raedalroughani riskfactorsofwhitematterhyperintensitiesinmigrainepatients AT khaledgad riskfactorsofwhitematterhyperintensitiesinmigrainepatients AT lamiaaalsarraf riskfactorsofwhitematterhyperintensitiesinmigrainepatients AT samarfaroukahmed riskfactorsofwhitematterhyperintensitiesinmigrainepatients |