Drug interactions among older adults followed up in a comprehensive medication management service at Primary Care
ABSTRACT Objective: To estimate the prevalence of drug interactions and associated factors among older adults followed up in a Comprehensive Medication Management Service at Primary Care. Methods: Firstly, the Beers criteria 2015 was used to define drug interactions; later, drug interactions propo...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
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| Series: | Einstein (São Paulo) |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000400207&lng=en&tlng=en |
| _version_ | 1819263148947931136 |
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| author | Tayane Oliveira dos Santos Mariana Martins Gonzaga do Nascimento Yone Almeida Nascimento Grazielli Cristina Batista de Oliveira Ursula Carolina de Morais Martins Danielle Fernandes da Silva Djenane Ramalho de Oliveira |
| author_facet | Tayane Oliveira dos Santos Mariana Martins Gonzaga do Nascimento Yone Almeida Nascimento Grazielli Cristina Batista de Oliveira Ursula Carolina de Morais Martins Danielle Fernandes da Silva Djenane Ramalho de Oliveira |
| author_sort | Tayane Oliveira dos Santos |
| collection | DOAJ |
| description | ABSTRACT Objective: To estimate the prevalence of drug interactions and associated factors among older adults followed up in a Comprehensive Medication Management Service at Primary Care. Methods: Firstly, the Beers criteria 2015 was used to define drug interactions; later, drug interactions proposed by Dumbreck for patients with diabetes, depression, and heart failure were evaluated. The associated factors were assessed by univariate (Pearson's χ2) and multivariate analyses (logistic regression). The significance level of 5% was set for all analyses. Results: The mean age of the studied population was 70.2±7.8 years; 52.2% were between 60 and 69 years, and 61.3% were female. Among the older adults, 94.5% used two or more drugs (condition for the occurrence of drug-drug interaction). The prevalence of drug interaction according to the Beers criteria was 4.9%. After multivariate analysis, diseases of the central nervous system, arrhythmia, number of medications, and female sex were positively associated with drug interaction. The prevalence of drug interaction according to Dumbreck was 27.2%. After multivariate analysis, the number of medications, the presence of heart failure, and Charlson comorbidity index greater than 1 were conditions positively associated with drug interactions. Conclusion: The holistic and individualized approach used in comprehensive medication management services for older patients is important, considering the prevalence of drug interactions and the need to minimize adverse events. |
| first_indexed | 2024-12-23T20:08:59Z |
| format | Article |
| id | doaj.art-9aa05b93e5b543a4ac81c5f24967f029 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-12-23T20:08:59Z |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-9aa05b93e5b543a4ac81c5f24967f0292022-12-21T17:32:51ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-638517410.31744/einstein_journal/2019ao4725S1679-45082019000400207Drug interactions among older adults followed up in a comprehensive medication management service at Primary CareTayane Oliveira dos SantosMariana Martins Gonzaga do NascimentoYone Almeida NascimentoGrazielli Cristina Batista de OliveiraUrsula Carolina de Morais MartinsDanielle Fernandes da SilvaDjenane Ramalho de OliveiraABSTRACT Objective: To estimate the prevalence of drug interactions and associated factors among older adults followed up in a Comprehensive Medication Management Service at Primary Care. Methods: Firstly, the Beers criteria 2015 was used to define drug interactions; later, drug interactions proposed by Dumbreck for patients with diabetes, depression, and heart failure were evaluated. The associated factors were assessed by univariate (Pearson's χ2) and multivariate analyses (logistic regression). The significance level of 5% was set for all analyses. Results: The mean age of the studied population was 70.2±7.8 years; 52.2% were between 60 and 69 years, and 61.3% were female. Among the older adults, 94.5% used two or more drugs (condition for the occurrence of drug-drug interaction). The prevalence of drug interaction according to the Beers criteria was 4.9%. After multivariate analysis, diseases of the central nervous system, arrhythmia, number of medications, and female sex were positively associated with drug interaction. The prevalence of drug interaction according to Dumbreck was 27.2%. After multivariate analysis, the number of medications, the presence of heart failure, and Charlson comorbidity index greater than 1 were conditions positively associated with drug interactions. Conclusion: The holistic and individualized approach used in comprehensive medication management services for older patients is important, considering the prevalence of drug interactions and the need to minimize adverse events.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000400207&lng=en&tlng=enInterações medicamentosasIdosoConduta do tratamento medicamentosoLista de medicamentos potencialmente inapropriadosFarmacêuticos |
| spellingShingle | Tayane Oliveira dos Santos Mariana Martins Gonzaga do Nascimento Yone Almeida Nascimento Grazielli Cristina Batista de Oliveira Ursula Carolina de Morais Martins Danielle Fernandes da Silva Djenane Ramalho de Oliveira Drug interactions among older adults followed up in a comprehensive medication management service at Primary Care Einstein (São Paulo) Interações medicamentosas Idoso Conduta do tratamento medicamentoso Lista de medicamentos potencialmente inapropriados Farmacêuticos |
| title | Drug interactions among older adults followed up in a comprehensive medication management service at Primary Care |
| title_full | Drug interactions among older adults followed up in a comprehensive medication management service at Primary Care |
| title_fullStr | Drug interactions among older adults followed up in a comprehensive medication management service at Primary Care |
| title_full_unstemmed | Drug interactions among older adults followed up in a comprehensive medication management service at Primary Care |
| title_short | Drug interactions among older adults followed up in a comprehensive medication management service at Primary Care |
| title_sort | drug interactions among older adults followed up in a comprehensive medication management service at primary care |
| topic | Interações medicamentosas Idoso Conduta do tratamento medicamentoso Lista de medicamentos potencialmente inapropriados Farmacêuticos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000400207&lng=en&tlng=en |
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