Effect of prolactin on penile erection: a cross-sectional study
Although elevated prolactin levels have been shown to inhibit penile erection, the relationship between prolactin and erection of the penile tip or base has not been extensively researched. We therefore investigated the prolactin's effects on erection of the penile tip and base, with a cross-se...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2019;volume=21;issue=6;spage=587;epage=591;aulast=Xu |
| _version_ | 1819260663741022208 |
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| author | Zhi-He Xu Dong Pan Tong-Yan Liu Ming-Zhen Yuan Jian-Ye Zhang Shan Jiang Xue-Sheng Wang Yong Guan Sheng-Tian Zhao |
| author_facet | Zhi-He Xu Dong Pan Tong-Yan Liu Ming-Zhen Yuan Jian-Ye Zhang Shan Jiang Xue-Sheng Wang Yong Guan Sheng-Tian Zhao |
| author_sort | Zhi-He Xu |
| collection | DOAJ |
| description | Although elevated prolactin levels have been shown to inhibit penile erection, the relationship between prolactin and erection of the penile tip or base has not been extensively researched. We therefore investigated the prolactin's effects on erection of the penile tip and base, with a cross-sectional study of 135 patients with erectile dysfunction, based on scores of ≤21 on the International Index of Erectile Function-5. All patients were tested for nocturnal penile tumescence, blood pressure, serum glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, luteinizing hormone, follicle-stimulating hormone, prolactin, estradiol, testosterone, and progesterone. Univariate and multivariate analyses were used to assess the associations between prolactin levels and erection at the penile tip and base. We found no obvious relationship between erection time at penile tip and prolactin levels, but observed a negative correlation between base erection time and prolactin level (hazard ratio: −2.68; 95% confidence interval [CI]: −5.13–−0.22). With increasing prolactin concentration, multivariate analysis showed obvious reduction in base erection time among patients with normal Rigiscan results (hazard ratio: −3.10; 95% CI: −7.96–1.77; P < 0.05). Our data indicate that prolactin inhibits penile erection, particularly at the penile base. In addition, when the effective erection time of the penile base lasts longer than 10 min, prolactin has a more obvious inhibitory effect on penile base erection. |
| first_indexed | 2024-12-23T19:29:29Z |
| format | Article |
| id | doaj.art-9aa30cbbba2f49b3844d4a5b639180df |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-23T19:29:29Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-9aa30cbbba2f49b3844d4a5b639180df2022-12-21T17:33:57ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622019-01-0121658759110.4103/aja.aja_22_19Effect of prolactin on penile erection: a cross-sectional studyZhi-He XuDong PanTong-Yan LiuMing-Zhen YuanJian-Ye ZhangShan JiangXue-Sheng WangYong GuanSheng-Tian ZhaoAlthough elevated prolactin levels have been shown to inhibit penile erection, the relationship between prolactin and erection of the penile tip or base has not been extensively researched. We therefore investigated the prolactin's effects on erection of the penile tip and base, with a cross-sectional study of 135 patients with erectile dysfunction, based on scores of ≤21 on the International Index of Erectile Function-5. All patients were tested for nocturnal penile tumescence, blood pressure, serum glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, luteinizing hormone, follicle-stimulating hormone, prolactin, estradiol, testosterone, and progesterone. Univariate and multivariate analyses were used to assess the associations between prolactin levels and erection at the penile tip and base. We found no obvious relationship between erection time at penile tip and prolactin levels, but observed a negative correlation between base erection time and prolactin level (hazard ratio: −2.68; 95% confidence interval [CI]: −5.13–−0.22). With increasing prolactin concentration, multivariate analysis showed obvious reduction in base erection time among patients with normal Rigiscan results (hazard ratio: −3.10; 95% CI: −7.96–1.77; P < 0.05). Our data indicate that prolactin inhibits penile erection, particularly at the penile base. In addition, when the effective erection time of the penile base lasts longer than 10 min, prolactin has a more obvious inhibitory effect on penile base erection.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2019;volume=21;issue=6;spage=587;epage=591;aulast=Xuerectile dysfunction; penile base; penile tip; prolactin; rigiscan |
| spellingShingle | Zhi-He Xu Dong Pan Tong-Yan Liu Ming-Zhen Yuan Jian-Ye Zhang Shan Jiang Xue-Sheng Wang Yong Guan Sheng-Tian Zhao Effect of prolactin on penile erection: a cross-sectional study Asian Journal of Andrology erectile dysfunction; penile base; penile tip; prolactin; rigiscan |
| title | Effect of prolactin on penile erection: a cross-sectional study |
| title_full | Effect of prolactin on penile erection: a cross-sectional study |
| title_fullStr | Effect of prolactin on penile erection: a cross-sectional study |
| title_full_unstemmed | Effect of prolactin on penile erection: a cross-sectional study |
| title_short | Effect of prolactin on penile erection: a cross-sectional study |
| title_sort | effect of prolactin on penile erection a cross sectional study |
| topic | erectile dysfunction; penile base; penile tip; prolactin; rigiscan |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2019;volume=21;issue=6;spage=587;epage=591;aulast=Xu |
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