A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10354-2 |
| _version_ | 1818977893863129088 |
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| author | Yanxian Feng Ruoyu Mu Zhenzhen Wang Panfei Xing Junfeng Zhang Lei Dong Chunming Wang |
| author_facet | Yanxian Feng Ruoyu Mu Zhenzhen Wang Panfei Xing Junfeng Zhang Lei Dong Chunming Wang |
| author_sort | Yanxian Feng |
| collection | DOAJ |
| description | Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe anti-tumour immune response in mouse models. |
| first_indexed | 2024-12-20T16:34:59Z |
| format | Article |
| id | doaj.art-9aa47db6d2924d21a6cc304bb0016e97 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:34:59Z |
| publishDate | 2019-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9aa47db6d2924d21a6cc304bb0016e972022-12-21T19:33:11ZengNature PortfolioNature Communications2041-17232019-05-0110111410.1038/s41467-019-10354-2A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophagesYanxian Feng0Ruoyu Mu1Zhenzhen Wang2Panfei Xing3Junfeng Zhang4Lei Dong5Chunming Wang6State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing UniversityState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing UniversityState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauTurning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe anti-tumour immune response in mouse models.https://doi.org/10.1038/s41467-019-10354-2 |
| spellingShingle | Yanxian Feng Ruoyu Mu Zhenzhen Wang Panfei Xing Junfeng Zhang Lei Dong Chunming Wang A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages Nature Communications |
| title | A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages |
| title_full | A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages |
| title_fullStr | A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages |
| title_full_unstemmed | A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages |
| title_short | A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages |
| title_sort | toll like receptor agonist mimicking microbial signal to generate tumor suppressive macrophages |
| url | https://doi.org/10.1038/s41467-019-10354-2 |
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