| Summary: | Digital asthenopia (DA) or Computer Vision Syndrome can occur after prolonged use of digital devices and is usually managed with ergophthalmological measures and the use of artificial tears. This prospective, controlled study evaluated the use of hyaluronic acid artificial tears on the signs and symptoms of DA in participants of a videogame convention. Subjects (<i>n</i> = 56) were randomized into a control group (CG, <i>n</i> = 26), which followed ergophthalmological measures, and a study group (SG, <i>n</i> = 30), which followed ergophthalmological measures and instilled 1 drop of artificial tears with hyaluronic acid 0.15% four times a day. Subjects were evaluated before and after playing for three consecutive days for eye dryness (SPEED questionnaire), conjunctival hyperemia, corneal fluorescein staining, conjunctival lissamine green staining, tear breakup time, Schirmer I test, near convergence and accommodation, and using questionnaires for DA symptoms. After 3 days of intense videogaming, the SPEED score of CG increased significantly (<i>p</i> = 0.0320), while for the SG it was unchanged. Similarly, the CG presented significant increases in ocular fatigue (<i>p</i> = 0.0173) and dryness (<i>p</i> = 0.0463), while these parameters decreased significantly in the SG (<i>p</i> = 0.0149 and <i>p</i> = 0.00427, respectively). This study confirms the protective effect of hyaluronic acid artificial tears against DA symptoms associated with prolonged visual display terminal use.
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