Clinical signs, diagnosis, and case reports of Vaccinia virus infections
Vaccinia virus is responsible for a zoonosis that usually affects cattle and human beings in Brazil. The initial clinical signs of the infection are focal red skin areas, fever, and general symptoms similar to those of a cold. Then, pustules and ulcerated lesions surrounded by edema and erythema fol...
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| Format: | Article |
| Language: | English |
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Elsevier
2010-03-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867010700258 |
| _version_ | 1811300942504525824 |
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| author | Daniela Carla Medeiros-Silva Eduardo Augusto dos Santos Moreira-Silva Juliana de Assis Silva Gomes Flávio Guimarães da Fonseca Rodrigo Correa-Oliveira |
| author_facet | Daniela Carla Medeiros-Silva Eduardo Augusto dos Santos Moreira-Silva Juliana de Assis Silva Gomes Flávio Guimarães da Fonseca Rodrigo Correa-Oliveira |
| author_sort | Daniela Carla Medeiros-Silva |
| collection | DOAJ |
| description | Vaccinia virus is responsible for a zoonosis that usually affects cattle and human beings in Brazil. The initial clinical signs of the infection are focal red skin areas, fever, and general symptoms similar to those of a cold. Then, pustules and ulcerated lesions surrounded by edema and erythema follow, as well as local lymphadenopathy that can last for weeks. Cure and healing of the lesions occur over several weeks, leaving a typical scar in the skin of people and animals affected. The infection definitive diagnosis is made through morphological characterization of the virus by use of electron microscopy, followed by PCR for specific viral genes. Since 1963, circulating orthopoxviruses in infectious outbreaks in several regions of Brazil have been reported. Later, the etiological agent of those infections was characterized as samples of Vaccinia virus. In addition, the widespread use of those viruses in research laboratories and mass vaccination of militaries have contributed to increase the cases of those infections worldwide. Thus, several epidemiological and clinical studies are required, as well as studies of viral immunology, public health, and economic impact, because little is known about those Vaccinia virus outbreaks in Brazil. Keywords: Poxviridae infections, virology, outbreaks, zoonoses, Vaccinia virus |
| first_indexed | 2024-04-13T07:00:00Z |
| format | Article |
| id | doaj.art-9aa64bbc0aa9450494ac710c98e0ceb6 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-04-13T07:00:00Z |
| publishDate | 2010-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-9aa64bbc0aa9450494ac710c98e0ceb62022-12-22T02:57:09ZengElsevierBrazilian Journal of Infectious Diseases1413-86702010-03-01142129134Clinical signs, diagnosis, and case reports of Vaccinia virus infectionsDaniela Carla Medeiros-Silva0Eduardo Augusto dos Santos Moreira-Silva1Juliana de Assis Silva Gomes2Flávio Guimarães da Fonseca3Rodrigo Correa-Oliveira4Centro de Pesquisas René Rachou (CPqRR), Fundação Oswaldo Cruz (Fiocruz), MG, Brazil, Ministério da Saúde; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG)Centro de Pesquisas René Rachou (CPqRR), Fundação Oswaldo Cruz (Fiocruz), MG, Brazil, Ministério da Saúde; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG); Correspondence to: Av. Dom Orione, 75 – São Luiz; Belo Horizonte – MG – Brazil CEP: 31310-020. Phone: 55 31 88079591.Centro de Pesquisas René Rachou (CPqRR), Fundação Oswaldo Cruz (Fiocruz), MG, Brazil, Ministério da Saúde; Department of Morphology, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG)Centro de Pesquisas René Rachou (CPqRR), Fundação Oswaldo Cruz (Fiocruz), MG, Brazil, Ministério da Saúde; Department of Microbiology, Biological Sciences Institute (ICB), Universidade Federal de Minas Gerais (UFMG)Centro de Pesquisas René Rachou (CPqRR), Fundação Oswaldo Cruz (Fiocruz), MG, Brazil, Ministério da SaúdeVaccinia virus is responsible for a zoonosis that usually affects cattle and human beings in Brazil. The initial clinical signs of the infection are focal red skin areas, fever, and general symptoms similar to those of a cold. Then, pustules and ulcerated lesions surrounded by edema and erythema follow, as well as local lymphadenopathy that can last for weeks. Cure and healing of the lesions occur over several weeks, leaving a typical scar in the skin of people and animals affected. The infection definitive diagnosis is made through morphological characterization of the virus by use of electron microscopy, followed by PCR for specific viral genes. Since 1963, circulating orthopoxviruses in infectious outbreaks in several regions of Brazil have been reported. Later, the etiological agent of those infections was characterized as samples of Vaccinia virus. In addition, the widespread use of those viruses in research laboratories and mass vaccination of militaries have contributed to increase the cases of those infections worldwide. Thus, several epidemiological and clinical studies are required, as well as studies of viral immunology, public health, and economic impact, because little is known about those Vaccinia virus outbreaks in Brazil. Keywords: Poxviridae infections, virology, outbreaks, zoonoses, Vaccinia virushttp://www.sciencedirect.com/science/article/pii/S1413867010700258 |
| spellingShingle | Daniela Carla Medeiros-Silva Eduardo Augusto dos Santos Moreira-Silva Juliana de Assis Silva Gomes Flávio Guimarães da Fonseca Rodrigo Correa-Oliveira Clinical signs, diagnosis, and case reports of Vaccinia virus infections Brazilian Journal of Infectious Diseases |
| title | Clinical signs, diagnosis, and case reports of Vaccinia virus infections |
| title_full | Clinical signs, diagnosis, and case reports of Vaccinia virus infections |
| title_fullStr | Clinical signs, diagnosis, and case reports of Vaccinia virus infections |
| title_full_unstemmed | Clinical signs, diagnosis, and case reports of Vaccinia virus infections |
| title_short | Clinical signs, diagnosis, and case reports of Vaccinia virus infections |
| title_sort | clinical signs diagnosis and case reports of vaccinia virus infections |
| url | http://www.sciencedirect.com/science/article/pii/S1413867010700258 |
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