Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata
Abstract The dried root of Saposhnikovia divaricata (Turcz.) Schischk. is popular as a good medicinal material, however the abundant aerial part is often discarded, which caused the waste of resources. In order to exploit resources, the essential oils of the plant aerial part and root were extracted...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-35656-w |
| _version_ | 1797811560928772096 |
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| author | Bing Li Zhenmin Yang Fuying Mao Qian Wang Huiyong Fang Xian Gu Kaiyan Zheng Yuguang Zheng Yunsheng Zhao Jianming Jiang |
| author_facet | Bing Li Zhenmin Yang Fuying Mao Qian Wang Huiyong Fang Xian Gu Kaiyan Zheng Yuguang Zheng Yunsheng Zhao Jianming Jiang |
| author_sort | Bing Li |
| collection | DOAJ |
| description | Abstract The dried root of Saposhnikovia divaricata (Turcz.) Schischk. is popular as a good medicinal material, however the abundant aerial part is often discarded, which caused the waste of resources. In order to exploit resources, the essential oils of the plant aerial part and root were extracted, separately called as VOA and VOR, their chemicals were identified. The tumor necrosis factor-α, interleukin-6, nitric oxide and interleukin-1β were detected to evaluate the oils anti-inflammatory activities. Then, the oils free radical scavenging rates were measured with DPPH, ABTS and hydroxyl free radical. The oils antitumor activities were evaluated with HeLa and HCT-8 cancer cell lines. The results showed the concentrations of VOA and VOR were separately 0.261% and 0.475%. Seventeen components of VOA were identified, accounting for 80.48% of VOA, including phytol, spathulenol, phytone, 4(15),5,10(14)-Germacratrien-1-ol, neophytadiene, etc. Seven components of VOR were determined, representing 90.73% of VOR, consisted of panaxynol, β-bisabolene, etc. VOA and VOR significantly inhibited the secretion of nitric oxide, interleukin-1β, interleukin‐6 and tumor necrosis factor-α, effectively scavenged the DPPH, ABTS and hydroxyl free radicals, and showed significant antiproliferative activity against HeLa and HCT-8. The two oils presented important biological activity, which provided a hopeful utilized basis, and helped to reduce the waste of the aerial non-medicinal resources of S. divaricata. |
| first_indexed | 2024-03-13T07:25:34Z |
| format | Article |
| id | doaj.art-9aa9c2027dd6458a8541de84903b10e7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T07:25:34Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9aa9c2027dd6458a8541de84903b10e72023-06-04T11:25:20ZengNature PortfolioScientific Reports2045-23222023-05-0113111310.1038/s41598-023-35656-wPhytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricataBing Li0Zhenmin Yang1Fuying Mao2Qian Wang3Huiyong Fang4Xian Gu5Kaiyan Zheng6Yuguang Zheng7Yunsheng Zhao8Jianming Jiang9College of Pharmacy, Hebei University of Chinese MedicineCollege of Pharmacy, Hebei University of Chinese MedicineExperimental Center, Hebei University of Chinese MedicineCollege of Pharmacy, Hebei University of Chinese MedicineCollege of Pharmacy, Hebei University of Chinese MedicineCollege of Pharmacy, Hebei University of Chinese MedicineCollege of Pharmacy, Hebei University of Chinese MedicineTraditional Chinese Medicine Processing Technology Innovation Center of Hebei ProvinceCollege of Pharmacy, Hebei University of Chinese MedicineCollege of Pharmacy, Hebei University of Chinese MedicineAbstract The dried root of Saposhnikovia divaricata (Turcz.) Schischk. is popular as a good medicinal material, however the abundant aerial part is often discarded, which caused the waste of resources. In order to exploit resources, the essential oils of the plant aerial part and root were extracted, separately called as VOA and VOR, their chemicals were identified. The tumor necrosis factor-α, interleukin-6, nitric oxide and interleukin-1β were detected to evaluate the oils anti-inflammatory activities. Then, the oils free radical scavenging rates were measured with DPPH, ABTS and hydroxyl free radical. The oils antitumor activities were evaluated with HeLa and HCT-8 cancer cell lines. The results showed the concentrations of VOA and VOR were separately 0.261% and 0.475%. Seventeen components of VOA were identified, accounting for 80.48% of VOA, including phytol, spathulenol, phytone, 4(15),5,10(14)-Germacratrien-1-ol, neophytadiene, etc. Seven components of VOR were determined, representing 90.73% of VOR, consisted of panaxynol, β-bisabolene, etc. VOA and VOR significantly inhibited the secretion of nitric oxide, interleukin-1β, interleukin‐6 and tumor necrosis factor-α, effectively scavenged the DPPH, ABTS and hydroxyl free radicals, and showed significant antiproliferative activity against HeLa and HCT-8. The two oils presented important biological activity, which provided a hopeful utilized basis, and helped to reduce the waste of the aerial non-medicinal resources of S. divaricata.https://doi.org/10.1038/s41598-023-35656-w |
| spellingShingle | Bing Li Zhenmin Yang Fuying Mao Qian Wang Huiyong Fang Xian Gu Kaiyan Zheng Yuguang Zheng Yunsheng Zhao Jianming Jiang Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata Scientific Reports |
| title | Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata |
| title_full | Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata |
| title_fullStr | Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata |
| title_full_unstemmed | Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata |
| title_short | Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata |
| title_sort | phytochemical profile and biological activities of the essential oils in the aerial part and root of saposhnikovia divaricata |
| url | https://doi.org/10.1038/s41598-023-35656-w |
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