Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia?
Abstract Background Compromised intestinal barrier integrity can be independently driven by hyperglycemia, and both hyperglycemia and intestinal barrier injury are associated with poor prognosis in critical illness. This study investigated the intestinal barrier biomarkers in critically ill patients...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-022-00943-5 |
| _version_ | 1798016834461499392 |
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| author | Yi-Feng Wang Feng-Ming Liang Min Liu Li-Cheng Ding Jiao-Jie Hui Hong-Yang Xu Li-Jun Liu |
| author_facet | Yi-Feng Wang Feng-Ming Liang Min Liu Li-Cheng Ding Jiao-Jie Hui Hong-Yang Xu Li-Jun Liu |
| author_sort | Yi-Feng Wang |
| collection | DOAJ |
| description | Abstract Background Compromised intestinal barrier integrity can be independently driven by hyperglycemia, and both hyperglycemia and intestinal barrier injury are associated with poor prognosis in critical illness. This study investigated the intestinal barrier biomarkers in critically ill patients, to explore the role of compromised intestinal barrier integrity on the prognosis of critically ill patients with pre-existing hyperglycemia. Methods This was a retrospective observational study. The relationships between intestinal barrier biomarkers and glycated hemoglobin A1c (HbA1c), fasting blood glucose (FBG), indicators of clinical characteristics, disease severity, and prognosis in critically ill patients were investigated. Then the metrics mentioned above were compared between survivors and non-survivors, the risk factors of 90-day mortality were investigated by logistic regression analysis. Further, patients were divided into HbA1c < 6.5% Group and HbA1c ≥ 6.5% Group, metrics mentioned above were compared between these two groups. Results A total of 109 patients with critical illness were included in the study. D-lactate and lipopolysaccharide (LPS) were associated with sequential organ failure assessment (SOFA) score and 90-day mortality. LPS was an independent risk factor of 90-day mortality. DAO, NEU (neutrophil) proportion, temperature, lactate were lower in HbA1c ≥ 6.5% Group while D-lactate, LPS, indicators of disease severity and prognosis showed no statistical difference between HbA1c < 6.5% Group and HbA1c ≥ 6.5% Group. Conclusions Intestinal barrier integrity is associated with the disease severity and prognosis in critical illness. Compromised intestinal barrier integrity might be responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia. |
| first_indexed | 2024-04-11T15:55:53Z |
| format | Article |
| id | doaj.art-9aa9c3d9ef0049dab95e081b50b95891 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-11T15:55:53Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-9aa9c3d9ef0049dab95e081b50b958912022-12-22T04:15:09ZengBMCDiabetology & Metabolic Syndrome1758-59962022-11-0114111110.1186/s13098-022-00943-5Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia?Yi-Feng Wang0Feng-Ming Liang1Min Liu2Li-Cheng Ding3Jiao-Jie Hui4Hong-Yang Xu5Li-Jun Liu6Department of Critical Care Medicine, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of Critical Care Medicine, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of Critical Care Medicine, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of Emergency Medicine, Affiliated Hospital of Jiangnan UniversityDepartment of Critical Care Medicine, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of Critical Care Medicine, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of Emergency and Critical Care Medicine, Second Affiliated Hospital of Soochow UniversityAbstract Background Compromised intestinal barrier integrity can be independently driven by hyperglycemia, and both hyperglycemia and intestinal barrier injury are associated with poor prognosis in critical illness. This study investigated the intestinal barrier biomarkers in critically ill patients, to explore the role of compromised intestinal barrier integrity on the prognosis of critically ill patients with pre-existing hyperglycemia. Methods This was a retrospective observational study. The relationships between intestinal barrier biomarkers and glycated hemoglobin A1c (HbA1c), fasting blood glucose (FBG), indicators of clinical characteristics, disease severity, and prognosis in critically ill patients were investigated. Then the metrics mentioned above were compared between survivors and non-survivors, the risk factors of 90-day mortality were investigated by logistic regression analysis. Further, patients were divided into HbA1c < 6.5% Group and HbA1c ≥ 6.5% Group, metrics mentioned above were compared between these two groups. Results A total of 109 patients with critical illness were included in the study. D-lactate and lipopolysaccharide (LPS) were associated with sequential organ failure assessment (SOFA) score and 90-day mortality. LPS was an independent risk factor of 90-day mortality. DAO, NEU (neutrophil) proportion, temperature, lactate were lower in HbA1c ≥ 6.5% Group while D-lactate, LPS, indicators of disease severity and prognosis showed no statistical difference between HbA1c < 6.5% Group and HbA1c ≥ 6.5% Group. Conclusions Intestinal barrier integrity is associated with the disease severity and prognosis in critical illness. Compromised intestinal barrier integrity might be responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia.https://doi.org/10.1186/s13098-022-00943-5Intestinal barrierHyperglycemiaCritical illnessPrognosis |
| spellingShingle | Yi-Feng Wang Feng-Ming Liang Min Liu Li-Cheng Ding Jiao-Jie Hui Hong-Yang Xu Li-Jun Liu Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia? Diabetology & Metabolic Syndrome Intestinal barrier Hyperglycemia Critical illness Prognosis |
| title | Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia? |
| title_full | Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia? |
| title_fullStr | Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia? |
| title_full_unstemmed | Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia? |
| title_short | Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia? |
| title_sort | is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre existing hyperglycemia |
| topic | Intestinal barrier Hyperglycemia Critical illness Prognosis |
| url | https://doi.org/10.1186/s13098-022-00943-5 |
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