Morphometrical Analysis of Developing Cochlear Ganglion Neurons: A Light Microscopic Fetal Study
Background and Aim: The cochlear or spiral ganglion neurons are the initial bridge between the external world of sound and its discernment in the brain. As the developing human fetal cochlea is known to start functioning in mid gestational period, its anatomical details when compared with adults...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5997/11323_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background and Aim: The cochlear or spiral ganglion neurons
are the initial bridge between the external world of sound and its
discernment in the brain. As the developing human fetal cochlea is
known to start functioning in mid gestational period, its anatomical
details when compared with adults could vary with each gestational
age. The aim of current study was to assess morphometrical
parameter of developing human fetal cochlear ganglion neurons
and comparison of data in each gestational period.
Materials and Methods: Ten aborted human fetuses from
14th to 28th weeks of gestation were procured from Department
of Obstetrics and Gynaecology of associated hospital, after
obtaining ethical clearance and were processed for studying
under light microscope. Area of neurons from each gestational age
was measured on histophotomicrographs using image Proplus
software. Standard statistical method was used to calculate area
range and percentage of small and large ganglion neurons.
Results: The neuronal area increased progressively in successively
higher gestation age fetuses. In the fetus belonging to lowest
gestational age the area ranged from 4-37µm2
while in highest
gestational age fetus its range was 10-58.3µm2
. The small ganglion
neurons were higher in 14 weeks (65.5%) fetuses and 16-20
weeks (81.03%) fetuses, while in higher gestational age fetuses’
large ganglion neuronal population was higher (62-66%).
Conclusion: A baseline morphometrical representation of fetal
cochlear ganglion neurons could be of relevance in advanced
human experimental studies on effect of neurotrophic factors in
human fetuses with congenital deafness. It has been found that
these factors directly influence neuronal maturation assessed by
progressive increase in soma size and survival. |
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| ISSN: | 2249-782X 0973-709X |