Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice
Background Activation of the intrarenal renin-angiotensin system (RAS) is implicated in the pathogenesis of kidney injury and hypertension. We aimed to investigate the protective effect of tetrahydrocurcumin (THU) on intrarenal RAS expression, kidney injury, and systolic blood pressure (SBP) in high...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2021-08-01
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| Series: | Endocrinology and Metabolism |
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| Online Access: | http://www.e-enm.org/upload/pdf/enm-2021-988.pdf |
| _version_ | 1818343413869707264 |
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| author | Weerapon Sangartit Kyung Bong Ha Eun Soo Lee Hong Min Kim Upa Kukongviriyapan Eun Young Lee Choon Hee Chung |
| author_facet | Weerapon Sangartit Kyung Bong Ha Eun Soo Lee Hong Min Kim Upa Kukongviriyapan Eun Young Lee Choon Hee Chung |
| author_sort | Weerapon Sangartit |
| collection | DOAJ |
| description | Background Activation of the intrarenal renin-angiotensin system (RAS) is implicated in the pathogenesis of kidney injury and hypertension. We aimed to investigate the protective effect of tetrahydrocurcumin (THU) on intrarenal RAS expression, kidney injury, and systolic blood pressure (SBP) in high-fat diet (HFD)-induced type 2 diabetic mice. Methods Eight-week-old male mice were fed a regular diet (RD) or HFD for 12 weeks, and THU (50 or 100 mg/kg/day) was intragastrically administered with HFD. Physiological and metabolic changes were monitored and the expression of RAS components and markers of kidney injury were assessed. Results HFD-fed mice exhibited hyperglycemia, insulin resistance, and dyslipidemia compared to those in the RD group (P<0.05). Kidney injury in these mice was indicated by an increase in the ratio of albumin to creatinine, glomerular hypertrophy, and the effacement of podocyte foot processes. Expression of intrarenal angiotensin-converting enzyme, angiotensin II type I receptor, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-4, and monocyte chemoattractant protein-1 was also markedly increased in HFD-fed mice. HFD-fed mice exhibited elevated SBP that was accompanied by an increase in the wall thickness and vascular cross-sectional area (P<0.05), 12 weeks post-HFD consumption. Treatment with THU (100 mg/kg/day) suppressed intrarenal RAS activation, improved insulin sensitivity, and reduced SBP, thus, attenuating kidney injury in these mice. Conclusion THU alleviated kidney injury in mice with HFD-induced type 2 diabetes, possibly by blunting the activation of the intrarenal RAS/nicotinamide adenine dinucleotide phosphate oxidase IV (NOX4)/monocyte chemoattractant protein 1 (MCP-1) axis and by lowering the high SBP. |
| first_indexed | 2024-12-13T16:30:12Z |
| format | Article |
| id | doaj.art-9aacaa93b2884ae88e267384eb395795 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-13T16:30:12Z |
| publishDate | 2021-08-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-9aacaa93b2884ae88e267384eb3957952022-12-21T23:38:32ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782021-08-0136481082210.3803/EnM.2021.9882208Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic MiceWeerapon Sangartit0Kyung Bong Ha1Eun Soo Lee2Hong Min Kim3Upa Kukongviriyapan4Eun Young Lee5Choon Hee Chung6 Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Astrogen Inc., Daegu, Korea Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Department of Internal Medicine and Institute of Tissue Regeneration, BK21 FOUR Project, Soonchunhyang University College of Medicine, Cheonan, Korea Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, KoreaBackground Activation of the intrarenal renin-angiotensin system (RAS) is implicated in the pathogenesis of kidney injury and hypertension. We aimed to investigate the protective effect of tetrahydrocurcumin (THU) on intrarenal RAS expression, kidney injury, and systolic blood pressure (SBP) in high-fat diet (HFD)-induced type 2 diabetic mice. Methods Eight-week-old male mice were fed a regular diet (RD) or HFD for 12 weeks, and THU (50 or 100 mg/kg/day) was intragastrically administered with HFD. Physiological and metabolic changes were monitored and the expression of RAS components and markers of kidney injury were assessed. Results HFD-fed mice exhibited hyperglycemia, insulin resistance, and dyslipidemia compared to those in the RD group (P<0.05). Kidney injury in these mice was indicated by an increase in the ratio of albumin to creatinine, glomerular hypertrophy, and the effacement of podocyte foot processes. Expression of intrarenal angiotensin-converting enzyme, angiotensin II type I receptor, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-4, and monocyte chemoattractant protein-1 was also markedly increased in HFD-fed mice. HFD-fed mice exhibited elevated SBP that was accompanied by an increase in the wall thickness and vascular cross-sectional area (P<0.05), 12 weeks post-HFD consumption. Treatment with THU (100 mg/kg/day) suppressed intrarenal RAS activation, improved insulin sensitivity, and reduced SBP, thus, attenuating kidney injury in these mice. Conclusion THU alleviated kidney injury in mice with HFD-induced type 2 diabetes, possibly by blunting the activation of the intrarenal RAS/nicotinamide adenine dinucleotide phosphate oxidase IV (NOX4)/monocyte chemoattractant protein 1 (MCP-1) axis and by lowering the high SBP.http://www.e-enm.org/upload/pdf/enm-2021-988.pdfdiabetic nephropathiesrenin-angiotensin systemhypertensiontetrahydrocurcumincurcumin |
| spellingShingle | Weerapon Sangartit Kyung Bong Ha Eun Soo Lee Hong Min Kim Upa Kukongviriyapan Eun Young Lee Choon Hee Chung Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice Endocrinology and Metabolism diabetic nephropathies renin-angiotensin system hypertension tetrahydrocurcumin curcumin |
| title | Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice |
| title_full | Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice |
| title_fullStr | Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice |
| title_full_unstemmed | Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice |
| title_short | Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice |
| title_sort | tetrahydrocurcumin ameliorates kidney injury and high systolic blood pressure in high fat diet induced type 2 diabetic mice |
| topic | diabetic nephropathies renin-angiotensin system hypertension tetrahydrocurcumin curcumin |
| url | http://www.e-enm.org/upload/pdf/enm-2021-988.pdf |
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