Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease
Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown. Methods and Results Adults with an ankle‐brachial index <...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-07-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.118.010890 |
| _version_ | 1811332647256850432 |
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| author | Tamar S. Polonsky Lu Tian Dongxue Zhang Lydia A. Bazzano Michael H. Criqui Luigi Ferrucci Jack M. Guralnik Melina R. Kibbe Christiaan Leeuwenburgh Robert L. Sufit Mary M. McDermott |
| author_facet | Tamar S. Polonsky Lu Tian Dongxue Zhang Lydia A. Bazzano Michael H. Criqui Luigi Ferrucci Jack M. Guralnik Melina R. Kibbe Christiaan Leeuwenburgh Robert L. Sufit Mary M. McDermott |
| author_sort | Tamar S. Polonsky |
| collection | DOAJ |
| description | Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown. Methods and Results Adults with an ankle‐brachial index <0.90 were identified from Chicago‐area hospitals in 2002–2004. Weight and 6‐minute walk distance were measured annually. Weight change categories were weight loss or gain (≥5 pounds/year at ≥1 visit) or stable (weight change <5 pounds at each visit). Participants reported whether weight loss was “intentional” or “unintentional.” Calf muscle area was measured with computed tomography every 2 years. Associations of weight change with changes in calf muscle area and 6‐minute walk distance were analyzed using mixed‐effects models and adjusted for age, body mass index, ankle‐brachial index, physical activity, and other confounders. Among 389 participants, mean ankle‐brachial index was 0.63±0.16, mean age was 74.5±7.8, and mean body mass index was 28.1±5.1 kg/m2. Over 3.23±1.37 years, muscle area declined more in adults with intentional weight loss versus stable or gain (pair‐wise comparisons, P<0.001). Intentional weight loss was associated with less annual decline in 6‐minute walk distance than weight gain (intentional loss, 3.7 m; stable, –14.0 m; gain, −28.5 m; unintentional loss, −20.8 m; pair‐wise comparison intentional loss versus gain, P=0.003). Conclusions Despite a greater loss of calf muscle area, adults with peripheral artery disease who intentionally lost ≥5 pounds experienced less functional decline than those who gained weight. A randomized trial is needed to establish whether benefits of weight loss in peripheral artery disease outweigh potential adverse effects. |
| first_indexed | 2024-04-13T16:40:12Z |
| format | Article |
| id | doaj.art-9aacedd1af614b8c980ca7e4d8e983f1 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T16:40:12Z |
| publishDate | 2019-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-9aacedd1af614b8c980ca7e4d8e983f12022-12-22T02:39:17ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802019-07-0181310.1161/JAHA.118.010890Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery DiseaseTamar S. Polonsky0Lu Tian1Dongxue Zhang2Lydia A. Bazzano3Michael H. Criqui4Luigi Ferrucci5Jack M. Guralnik6Melina R. Kibbe7Christiaan Leeuwenburgh8Robert L. Sufit9Mary M. McDermott10Department of Medicine University of Chicago Chicago ILDepartment of Health Research and Policy Stanford University Palo Alto CADepartment of Medicine Northwestern University Feinberg School of Medicine Chicago ILDepartment of Epidemiology Tulane School of Public Health and Tropical Medicine New Orleans LA USADepartment of Family Medicine and Public Health University of California at San Diego San Diego CADivision of Intramural Research National Institute on Aging Baltimore MDDepartment of Epidemiology and Public Health University of Maryland School of Medicine Baltimore MDDepartment of Surgery University of North Carolina Chapel Hill NCDepartment of Aging and Geriatric Research Institute on Aging University of Florida Gainesville FLDepartment of Medicine Northwestern University Feinberg School of Medicine Chicago ILDepartment of Medicine Northwestern University Feinberg School of Medicine Chicago ILBackground Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown. Methods and Results Adults with an ankle‐brachial index <0.90 were identified from Chicago‐area hospitals in 2002–2004. Weight and 6‐minute walk distance were measured annually. Weight change categories were weight loss or gain (≥5 pounds/year at ≥1 visit) or stable (weight change <5 pounds at each visit). Participants reported whether weight loss was “intentional” or “unintentional.” Calf muscle area was measured with computed tomography every 2 years. Associations of weight change with changes in calf muscle area and 6‐minute walk distance were analyzed using mixed‐effects models and adjusted for age, body mass index, ankle‐brachial index, physical activity, and other confounders. Among 389 participants, mean ankle‐brachial index was 0.63±0.16, mean age was 74.5±7.8, and mean body mass index was 28.1±5.1 kg/m2. Over 3.23±1.37 years, muscle area declined more in adults with intentional weight loss versus stable or gain (pair‐wise comparisons, P<0.001). Intentional weight loss was associated with less annual decline in 6‐minute walk distance than weight gain (intentional loss, 3.7 m; stable, –14.0 m; gain, −28.5 m; unintentional loss, −20.8 m; pair‐wise comparison intentional loss versus gain, P=0.003). Conclusions Despite a greater loss of calf muscle area, adults with peripheral artery disease who intentionally lost ≥5 pounds experienced less functional decline than those who gained weight. A randomized trial is needed to establish whether benefits of weight loss in peripheral artery disease outweigh potential adverse effects.https://www.ahajournals.org/doi/10.1161/JAHA.118.010890obesityobservational studiesperipheral artery diseasephysical exercise |
| spellingShingle | Tamar S. Polonsky Lu Tian Dongxue Zhang Lydia A. Bazzano Michael H. Criqui Luigi Ferrucci Jack M. Guralnik Melina R. Kibbe Christiaan Leeuwenburgh Robert L. Sufit Mary M. McDermott Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease obesity observational studies peripheral artery disease physical exercise |
| title | Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease |
| title_full | Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease |
| title_fullStr | Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease |
| title_full_unstemmed | Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease |
| title_short | Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease |
| title_sort | associations of weight change with changes in calf muscle characteristics and functional decline in peripheral artery disease |
| topic | obesity observational studies peripheral artery disease physical exercise |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.118.010890 |
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