Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis
Abstract Background Peritoneal dialysis (PD) is an effective and successful renal replacement therapy. The baseline peritoneal solute transfer rate (PSTR) is related to local membrane inflammation and may be partially genetically determined. Herein, we focused on vascular endothelial growth factor (...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
|
| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-022-02975-5 |
| _version_ | 1797983910610599936 |
|---|---|
| author | Yue Qian Li Ding Liou Cao Zanzhe Yu Xinghua Shao Ling Wang Minfang Zhang Qin Wang Xiajing Che Na Jiang Hao Yan Wei Fang Yan Jin Jiaying Huang Aiping Gu Zhaohui Ni |
| author_facet | Yue Qian Li Ding Liou Cao Zanzhe Yu Xinghua Shao Ling Wang Minfang Zhang Qin Wang Xiajing Che Na Jiang Hao Yan Wei Fang Yan Jin Jiaying Huang Aiping Gu Zhaohui Ni |
| author_sort | Yue Qian |
| collection | DOAJ |
| description | Abstract Background Peritoneal dialysis (PD) is an effective and successful renal replacement therapy. The baseline peritoneal solute transfer rate (PSTR) is related to local membrane inflammation and may be partially genetically determined. Herein, we focused on vascular endothelial growth factor (VEGF) and its receptor, kinase insert domain containing receptor (KDR). Methods This study recruited 200 PD patients from Renji Hospital in Shanghai, China. We analysed the association between the polymorphisms of VEGF and KDR and the 4-hour dialysate-to-plasma ratio for creatinine (4 h D/P Cr), which was measured between one and three months after initiating PD. Results The CC genotype in VEGF rs3025039 and the AA genotype in KDR rs2071559 were both positively associated with a fast baseline PSTR (VEGF rs3025039 CC vs. TT + TC: 0.65 ± 0.12 vs. 0.61 ± 0.11; P = 0.029; KDR rs2071559 AA vs. GA + GG: 0.65 ± 0.12 vs. 0.62 ± 0.12; P = 0.039). Conclusion Baseline PSTR was partly determined by VEGF and KDR gene polymorphisms. |
| first_indexed | 2024-04-11T06:54:48Z |
| format | Article |
| id | doaj.art-9aaeb0285f6541838bcd05892fe526d6 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-11T06:54:48Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-9aaeb0285f6541838bcd05892fe526d62022-12-22T04:39:04ZengBMCBMC Nephrology1471-23692022-11-012311710.1186/s12882-022-02975-5Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysisYue Qian0Li Ding1Liou Cao2Zanzhe Yu3Xinghua Shao4Ling Wang5Minfang Zhang6Qin Wang7Xiajing Che8Na Jiang9Hao Yan10Wei Fang11Yan Jin12Jiaying Huang13Aiping Gu14Zhaohui Ni15Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityAbstract Background Peritoneal dialysis (PD) is an effective and successful renal replacement therapy. The baseline peritoneal solute transfer rate (PSTR) is related to local membrane inflammation and may be partially genetically determined. Herein, we focused on vascular endothelial growth factor (VEGF) and its receptor, kinase insert domain containing receptor (KDR). Methods This study recruited 200 PD patients from Renji Hospital in Shanghai, China. We analysed the association between the polymorphisms of VEGF and KDR and the 4-hour dialysate-to-plasma ratio for creatinine (4 h D/P Cr), which was measured between one and three months after initiating PD. Results The CC genotype in VEGF rs3025039 and the AA genotype in KDR rs2071559 were both positively associated with a fast baseline PSTR (VEGF rs3025039 CC vs. TT + TC: 0.65 ± 0.12 vs. 0.61 ± 0.11; P = 0.029; KDR rs2071559 AA vs. GA + GG: 0.65 ± 0.12 vs. 0.62 ± 0.12; P = 0.039). Conclusion Baseline PSTR was partly determined by VEGF and KDR gene polymorphisms.https://doi.org/10.1186/s12882-022-02975-5Peritoneal dialysisVEGFKDRGene polymorphismsSNPPeritoneal solute transfer rate |
| spellingShingle | Yue Qian Li Ding Liou Cao Zanzhe Yu Xinghua Shao Ling Wang Minfang Zhang Qin Wang Xiajing Che Na Jiang Hao Yan Wei Fang Yan Jin Jiaying Huang Aiping Gu Zhaohui Ni Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis BMC Nephrology Peritoneal dialysis VEGF KDR Gene polymorphisms SNP Peritoneal solute transfer rate |
| title | Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis |
| title_full | Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis |
| title_fullStr | Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis |
| title_full_unstemmed | Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis |
| title_short | Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis |
| title_sort | gene polymorphisms of vegf and kdr are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis |
| topic | Peritoneal dialysis VEGF KDR Gene polymorphisms SNP Peritoneal solute transfer rate |
| url | https://doi.org/10.1186/s12882-022-02975-5 |
| work_keys_str_mv | AT yueqian genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT liding genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT lioucao genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT zanzheyu genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT xinghuashao genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT lingwang genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT minfangzhang genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT qinwang genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT xiajingche genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT najiang genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT haoyan genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT weifang genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT yanjin genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT jiayinghuang genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT aipinggu genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis AT zhaohuini genepolymorphismsofvegfandkdrareassociatedwithinitialfastperitonealsolutetransferrateinperitonealdialysis |