Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health
Developmental origin of health and disease postulates that the footprints of early life exposure are followed as an endowment of risk for adult diseases. Epidemiological and experimental evidence suggest that an adverse fetal environment can affect the health of offspring throughout their lifetime....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Toxicology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2021.663372/full |
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| author | Radha Dutt Singh Kavita Koshta Kavita Koshta Ratnakar Tiwari Hafizurrahman Khan Vineeta Sharma Vikas Srivastava Vikas Srivastava |
| author_facet | Radha Dutt Singh Kavita Koshta Kavita Koshta Ratnakar Tiwari Hafizurrahman Khan Vineeta Sharma Vikas Srivastava Vikas Srivastava |
| author_sort | Radha Dutt Singh |
| collection | DOAJ |
| description | Developmental origin of health and disease postulates that the footprints of early life exposure are followed as an endowment of risk for adult diseases. Epidemiological and experimental evidence suggest that an adverse fetal environment can affect the health of offspring throughout their lifetime. Exposure to endocrine disrupting chemicals (EDCs) during fetal development can affect the hormone system homeostasis, resulting in a broad spectrum of adverse health outcomes. In the present review, we have described the effect of prenatal EDCs exposure on cardio-metabolic-renal health, using the available epidemiological and experimental evidence. We also discuss the potential mechanisms of their action, which include epigenetic changes, hormonal imprinting, loss of energy homeostasis, and metabolic perturbations. The effect of prenatal EDCs exposure on cardio-metabolic-renal health, which is a complex condition of an altered biological landscape, can be further examined in the case of other environmental stressors with a similar mode of action. |
| first_indexed | 2024-12-19T21:55:51Z |
| format | Article |
| id | doaj.art-9aaf5301ab7e47abb27700a337ef8efc |
| institution | Directory Open Access Journal |
| issn | 2673-3080 |
| language | English |
| last_indexed | 2024-12-19T21:55:51Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Toxicology |
| spelling | doaj.art-9aaf5301ab7e47abb27700a337ef8efc2022-12-21T20:04:17ZengFrontiers Media S.A.Frontiers in Toxicology2673-30802021-07-01310.3389/ftox.2021.663372663372Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal HealthRadha Dutt Singh0Kavita Koshta1Kavita Koshta2Ratnakar Tiwari3Hafizurrahman Khan4Vineeta Sharma5Vikas Srivastava6Vikas Srivastava7Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, CanadaSystems Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow, IndiaAcademy of Scientific and Innovative Research, New Delhi, IndiaFeinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University Chicago, Chicago, IL, United StatesSystems Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow, IndiaSystems Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow, IndiaSystems Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow, IndiaAcademy of Scientific and Innovative Research, New Delhi, IndiaDevelopmental origin of health and disease postulates that the footprints of early life exposure are followed as an endowment of risk for adult diseases. Epidemiological and experimental evidence suggest that an adverse fetal environment can affect the health of offspring throughout their lifetime. Exposure to endocrine disrupting chemicals (EDCs) during fetal development can affect the hormone system homeostasis, resulting in a broad spectrum of adverse health outcomes. In the present review, we have described the effect of prenatal EDCs exposure on cardio-metabolic-renal health, using the available epidemiological and experimental evidence. We also discuss the potential mechanisms of their action, which include epigenetic changes, hormonal imprinting, loss of energy homeostasis, and metabolic perturbations. The effect of prenatal EDCs exposure on cardio-metabolic-renal health, which is a complex condition of an altered biological landscape, can be further examined in the case of other environmental stressors with a similar mode of action.https://www.frontiersin.org/articles/10.3389/ftox.2021.663372/fullprenatal exposureDOHADcardio-metabolic-renal healthendocrine disrupting chemicalscardiovascular disorder |
| spellingShingle | Radha Dutt Singh Kavita Koshta Kavita Koshta Ratnakar Tiwari Hafizurrahman Khan Vineeta Sharma Vikas Srivastava Vikas Srivastava Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health Frontiers in Toxicology prenatal exposure DOHAD cardio-metabolic-renal health endocrine disrupting chemicals cardiovascular disorder |
| title | Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health |
| title_full | Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health |
| title_fullStr | Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health |
| title_full_unstemmed | Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health |
| title_short | Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health |
| title_sort | developmental exposure to endocrine disrupting chemicals and its impact on cardio metabolic renal health |
| topic | prenatal exposure DOHAD cardio-metabolic-renal health endocrine disrupting chemicals cardiovascular disorder |
| url | https://www.frontiersin.org/articles/10.3389/ftox.2021.663372/full |
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