Spike-Timing of Orbitofrontal Neurons Is Synchronized With Breathing
The orbitofrontal cortex (OFC) has been implicated in a multiplicity of complex brain functions, including representations of expected outcome properties, post-decision confidence, momentary food-reward values, complex flavors and odors. As breathing rhythm has an influence on odor processing at pri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fncel.2018.00105/full |
| _version_ | 1818110936161976320 |
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| author | Áron Kőszeghy Bálint Lasztóczi Thomas Forro Thomas Klausberger |
| author_facet | Áron Kőszeghy Bálint Lasztóczi Thomas Forro Thomas Klausberger |
| author_sort | Áron Kőszeghy |
| collection | DOAJ |
| description | The orbitofrontal cortex (OFC) has been implicated in a multiplicity of complex brain functions, including representations of expected outcome properties, post-decision confidence, momentary food-reward values, complex flavors and odors. As breathing rhythm has an influence on odor processing at primary olfactory areas, we tested the hypothesis that it may also influence neuronal activity in the OFC, a prefrontal area involved also in higher order processing of odors. We recorded spike timing of orbitofrontal neurons as well as local field potentials (LFPs) in awake, head-fixed mice, together with the breathing rhythm. We observed that a large majority of orbitofrontal neurons showed robust phase-coupling to breathing during immobility and running. The phase coupling of action potentials to breathing was significantly stronger in orbitofrontal neurons compared to cells in the medial prefrontal cortex. The characteristic synchronization of orbitofrontal neurons with breathing might provide a temporal framework for multi-variable processing of olfactory, gustatory and reward-value relationships. |
| first_indexed | 2024-12-11T02:55:04Z |
| format | Article |
| id | doaj.art-9aafc9c5fc204e79be8b93f50bb0ef06 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T02:55:04Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-9aafc9c5fc204e79be8b93f50bb0ef062022-12-22T01:23:11ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-04-011210.3389/fncel.2018.00105350258Spike-Timing of Orbitofrontal Neurons Is Synchronized With BreathingÁron KőszeghyBálint LasztócziThomas ForroThomas KlausbergerThe orbitofrontal cortex (OFC) has been implicated in a multiplicity of complex brain functions, including representations of expected outcome properties, post-decision confidence, momentary food-reward values, complex flavors and odors. As breathing rhythm has an influence on odor processing at primary olfactory areas, we tested the hypothesis that it may also influence neuronal activity in the OFC, a prefrontal area involved also in higher order processing of odors. We recorded spike timing of orbitofrontal neurons as well as local field potentials (LFPs) in awake, head-fixed mice, together with the breathing rhythm. We observed that a large majority of orbitofrontal neurons showed robust phase-coupling to breathing during immobility and running. The phase coupling of action potentials to breathing was significantly stronger in orbitofrontal neurons compared to cells in the medial prefrontal cortex. The characteristic synchronization of orbitofrontal neurons with breathing might provide a temporal framework for multi-variable processing of olfactory, gustatory and reward-value relationships.http://journal.frontiersin.org/article/10.3389/fncel.2018.00105/fullorbitofrontal cortexventral prefrontal cortexmedial prefrontal cortexrespiratory rhythmhippocampal theta oscillationsolfactory bulb |
| spellingShingle | Áron Kőszeghy Bálint Lasztóczi Thomas Forro Thomas Klausberger Spike-Timing of Orbitofrontal Neurons Is Synchronized With Breathing Frontiers in Cellular Neuroscience orbitofrontal cortex ventral prefrontal cortex medial prefrontal cortex respiratory rhythm hippocampal theta oscillations olfactory bulb |
| title | Spike-Timing of Orbitofrontal Neurons Is Synchronized With Breathing |
| title_full | Spike-Timing of Orbitofrontal Neurons Is Synchronized With Breathing |
| title_fullStr | Spike-Timing of Orbitofrontal Neurons Is Synchronized With Breathing |
| title_full_unstemmed | Spike-Timing of Orbitofrontal Neurons Is Synchronized With Breathing |
| title_short | Spike-Timing of Orbitofrontal Neurons Is Synchronized With Breathing |
| title_sort | spike timing of orbitofrontal neurons is synchronized with breathing |
| topic | orbitofrontal cortex ventral prefrontal cortex medial prefrontal cortex respiratory rhythm hippocampal theta oscillations olfactory bulb |
| url | http://journal.frontiersin.org/article/10.3389/fncel.2018.00105/full |
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