Mapping spatial heterogeneity in gastric cancer microenvironment
Gastric cancer (GC) is difficult to characterize due to its heterogeneity, and the complicated heterogeneity leads to the difficulty of precisely targeted therapy. The spatially heterogeneous composition plays a crucial role in GC onset, progression, treatment efficacy, and drug resistance. In recen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224001987 |
| _version_ | 1797291845660704768 |
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| author | Bingyu Wang Buyun Song Yong Li Qun Zhao Bibo Tan |
| author_facet | Bingyu Wang Buyun Song Yong Li Qun Zhao Bibo Tan |
| author_sort | Bingyu Wang |
| collection | DOAJ |
| description | Gastric cancer (GC) is difficult to characterize due to its heterogeneity, and the complicated heterogeneity leads to the difficulty of precisely targeted therapy. The spatially heterogeneous composition plays a crucial role in GC onset, progression, treatment efficacy, and drug resistance. In recent years, the technological advancements in spatial omics has shifted our understanding of the tumor microenvironment (TME) from cancer-centered model to a dynamic and variant whole. In this review, we concentrated on the spatial heterogeneity within the primary lesions and between the primary and metastatic lesions of GC through the TME heterogeneity including the tertiary lymphoid structures (TLSs), the uniquely spatial organization. Meanwhile, the immune phenotype based on spatial distribution was also outlined. Furthermore, we recapitulated the clinical treatment in mediating spatial heterogeneity in GC, hoping to provide a systematic view of how spatial information could be integrated into anti-cancer immunity. |
| first_indexed | 2024-03-07T19:42:42Z |
| format | Article |
| id | doaj.art-9ab013a8bc074d9283448958169c530f |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-07T19:42:42Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-9ab013a8bc074d9283448958169c530f2024-02-29T05:18:02ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-03-01172116317Mapping spatial heterogeneity in gastric cancer microenvironmentBingyu Wang0Buyun Song1Yong Li2Qun Zhao3Bibo Tan4The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China; Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, ChinaThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China; Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, China; Corresponding author at: The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.Gastric cancer (GC) is difficult to characterize due to its heterogeneity, and the complicated heterogeneity leads to the difficulty of precisely targeted therapy. The spatially heterogeneous composition plays a crucial role in GC onset, progression, treatment efficacy, and drug resistance. In recent years, the technological advancements in spatial omics has shifted our understanding of the tumor microenvironment (TME) from cancer-centered model to a dynamic and variant whole. In this review, we concentrated on the spatial heterogeneity within the primary lesions and between the primary and metastatic lesions of GC through the TME heterogeneity including the tertiary lymphoid structures (TLSs), the uniquely spatial organization. Meanwhile, the immune phenotype based on spatial distribution was also outlined. Furthermore, we recapitulated the clinical treatment in mediating spatial heterogeneity in GC, hoping to provide a systematic view of how spatial information could be integrated into anti-cancer immunity.http://www.sciencedirect.com/science/article/pii/S0753332224001987Gastric cancerTumor microenvironmentSpatial heterogeneityTertiary lymphoid structures |
| spellingShingle | Bingyu Wang Buyun Song Yong Li Qun Zhao Bibo Tan Mapping spatial heterogeneity in gastric cancer microenvironment Biomedicine & Pharmacotherapy Gastric cancer Tumor microenvironment Spatial heterogeneity Tertiary lymphoid structures |
| title | Mapping spatial heterogeneity in gastric cancer microenvironment |
| title_full | Mapping spatial heterogeneity in gastric cancer microenvironment |
| title_fullStr | Mapping spatial heterogeneity in gastric cancer microenvironment |
| title_full_unstemmed | Mapping spatial heterogeneity in gastric cancer microenvironment |
| title_short | Mapping spatial heterogeneity in gastric cancer microenvironment |
| title_sort | mapping spatial heterogeneity in gastric cancer microenvironment |
| topic | Gastric cancer Tumor microenvironment Spatial heterogeneity Tertiary lymphoid structures |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224001987 |
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