Emerging Role of Non-Coding RNAs in Senescence
Senescence is defined as a gradual weakening of functional features of a living organism. Cellular senescence is a process that is principally aimed to remove undesirable cells by prompting tissue remodeling. This process is also regarded as a defense mechanism induced by cellular damage. In the cou...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.869011/full |
| _version_ | 1818536522470653952 |
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| author | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Bashdar Mahmud Hussen Aria Baniahmad Wojciech Branicki Mohammad Taheri Mohammad Taheri Ahmad Eghbali |
| author_facet | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Bashdar Mahmud Hussen Aria Baniahmad Wojciech Branicki Mohammad Taheri Mohammad Taheri Ahmad Eghbali |
| author_sort | Soudeh Ghafouri-Fard |
| collection | DOAJ |
| description | Senescence is defined as a gradual weakening of functional features of a living organism. Cellular senescence is a process that is principally aimed to remove undesirable cells by prompting tissue remodeling. This process is also regarded as a defense mechanism induced by cellular damage. In the course of oncogenesis, senescence can limit tumor progression. However, senescence participates in the pathoetiology of several disorders such as fibrotic disorders, vascular disorders, diabetes, renal disorders and sarcopenia. Recent studies have revealed contribution of different classes of non-coding RNAs in the cellular senescence. Long non-coding RNAs, microRNAs and circular RNAs are three classes of these transcripts whose contributions in this process have been more investigated. In the current review, we summarize the available literature on the impact of these transcripts in the cellular senescence. |
| first_indexed | 2024-12-11T18:39:02Z |
| format | Article |
| id | doaj.art-9ab214f9b96842158872bb71c6369b07 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-11T18:39:02Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9ab214f9b96842158872bb71c6369b072022-12-22T00:54:40ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-07-011010.3389/fcell.2022.869011869011Emerging Role of Non-Coding RNAs in SenescenceSoudeh Ghafouri-Fard0Tayyebeh Khoshbakht1Bashdar Mahmud Hussen2Bashdar Mahmud Hussen3Aria Baniahmad4Wojciech Branicki5Mohammad Taheri6Mohammad Taheri7Ahmad Eghbali8Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, IraqCenter of Research and Strategic Studies, Lebanese French University, Erbil, IraqInstitute of Human Genetics, Jena University Hospitals, Jena, GermanyMalopolska Centre of Biotechnology, Jagiellonian University, Krakow, PolandInstitute of Human Genetics, Jena University Hospitals, Jena, GermanyUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranAnesthesiology Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranSenescence is defined as a gradual weakening of functional features of a living organism. Cellular senescence is a process that is principally aimed to remove undesirable cells by prompting tissue remodeling. This process is also regarded as a defense mechanism induced by cellular damage. In the course of oncogenesis, senescence can limit tumor progression. However, senescence participates in the pathoetiology of several disorders such as fibrotic disorders, vascular disorders, diabetes, renal disorders and sarcopenia. Recent studies have revealed contribution of different classes of non-coding RNAs in the cellular senescence. Long non-coding RNAs, microRNAs and circular RNAs are three classes of these transcripts whose contributions in this process have been more investigated. In the current review, we summarize the available literature on the impact of these transcripts in the cellular senescence.https://www.frontiersin.org/articles/10.3389/fcell.2022.869011/fulllncRNAmiRNAsenescenceexpressionbiomarkerepigenetics |
| spellingShingle | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Bashdar Mahmud Hussen Aria Baniahmad Wojciech Branicki Mohammad Taheri Mohammad Taheri Ahmad Eghbali Emerging Role of Non-Coding RNAs in Senescence Frontiers in Cell and Developmental Biology lncRNA miRNA senescence expression biomarker epigenetics |
| title | Emerging Role of Non-Coding RNAs in Senescence |
| title_full | Emerging Role of Non-Coding RNAs in Senescence |
| title_fullStr | Emerging Role of Non-Coding RNAs in Senescence |
| title_full_unstemmed | Emerging Role of Non-Coding RNAs in Senescence |
| title_short | Emerging Role of Non-Coding RNAs in Senescence |
| title_sort | emerging role of non coding rnas in senescence |
| topic | lncRNA miRNA senescence expression biomarker epigenetics |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.869011/full |
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