Alteration of osteoclast activity in childhood cancer survivors: Role of iron and of CB2/TRPV1 receptors.

Alteration of osteoclast activity in childhood cancer survivors: Role of iron and of CB2/TRPV1 receptors.

Childhood cancer survivors (CCS) are predisposed to the onset of osteoporosis (OP). It is known that iron overload induces osteoclasts (OCs) overactivity and that the iron chelator Deferasirox (DFX) can counteract it. The Cannabinoid Receptor type 2 (CB2) and the transient receptor potential vanillo...

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Bibliographic Details
Main Authors: Francesca Rossi, Chiara Tortora, Martina Di Martino, Alessandra Di Paola, Daniela Di Pinto, Maria Maddalena Marrapodi, Maura Argenziano, Elvira Pota
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0271730

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https://doi.org/10.1371/journal.pone.0271730

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