Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.

Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.

Sirtuins (SIRT1-7) are a family of NAD-dependent deacetylases and/or ADP-ribosyltransferases that are involved in metabolism, stress responses and longevity. SIRT3 is localized to mitochondria, where it deacetylates and activates a number of enzymes involved in fuel oxidation and energy production.I...

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Bibliographic Details
Main Authors: Lydia W S Finley, Wilhelm Haas, Valérie Desquiret-Dumas, Douglas C Wallace, Vincent Procaccio, Steven P Gygi, Marcia C Haigis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3157345?pdf=render

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