EFFICACY AND SAFETY OF COMBINATION TREATMENT WITH ABATACEPT AND METHOTREXATE AND MONOTHERAPY WITH METHOTREXATE IN PATIENTS WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS
The results of efficacy and safety study of abatacept and methotrexate combination therapy (n=12) in comparison with methotrexate monotherapy (n =41) in patients with polyarticular juvenile idiopathic arthritis at the age of 4–17 years old are shown in this article. The duration of the observation w...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2012-11-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/408 |
| _version_ | 1797696843397726208 |
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| author | V. A. Kel'tsev L. I. Grebenkina N. S. Pryanichkova S. А. Gorunov N. V. Lagoda |
| author_facet | V. A. Kel'tsev L. I. Grebenkina N. S. Pryanichkova S. А. Gorunov N. V. Lagoda |
| author_sort | V. A. Kel'tsev |
| collection | DOAJ |
| description | The results of efficacy and safety study of abatacept and methotrexate combination therapy (n=12) in comparison with methotrexate monotherapy (n =41) in patients with polyarticular juvenile idiopathic arthritis at the age of 4–17 years old are shown in this article. The duration of the observation was 1 year. Abatacept was introduced at a dose of 10 mg/kg at 1st, 2d and then — every 4th week. In 48 weeks clinical remission and decrease of laboratory markers of activity was registered in 35% of patients treated with abatacept and methotrexate and in 16% of patients treated only with methotrexate. |
| first_indexed | 2024-03-12T03:32:00Z |
| format | Article |
| id | doaj.art-9ab5c894059c4653bad912dc49271ad6 |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T03:32:00Z |
| publishDate | 2012-11-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-9ab5c894059c4653bad912dc49271ad62023-09-03T13:24:30Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352012-11-0111610310910.15690/vsp.v11i6.500408EFFICACY AND SAFETY OF COMBINATION TREATMENT WITH ABATACEPT AND METHOTREXATE AND MONOTHERAPY WITH METHOTREXATE IN PATIENTS WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITISV. A. Kel'tsev0L. I. Grebenkina1N. S. Pryanichkova2S. А. Gorunov3N. V. Lagoda4Самарский государственный медицинский университетСамарский государственный медицинский университетСамарский государственный медицинский университетСамарский государственный медицинский университетСамарский государственный медицинский университетThe results of efficacy and safety study of abatacept and methotrexate combination therapy (n=12) in comparison with methotrexate monotherapy (n =41) in patients with polyarticular juvenile idiopathic arthritis at the age of 4–17 years old are shown in this article. The duration of the observation was 1 year. Abatacept was introduced at a dose of 10 mg/kg at 1st, 2d and then — every 4th week. In 48 weeks clinical remission and decrease of laboratory markers of activity was registered in 35% of patients treated with abatacept and methotrexate and in 16% of patients treated only with methotrexate.https://vsp.spr-journal.ru/jour/article/view/408детиювенильный идиопатический артритлечениеабатацептметотрексат |
| spellingShingle | V. A. Kel'tsev L. I. Grebenkina N. S. Pryanichkova S. А. Gorunov N. V. Lagoda EFFICACY AND SAFETY OF COMBINATION TREATMENT WITH ABATACEPT AND METHOTREXATE AND MONOTHERAPY WITH METHOTREXATE IN PATIENTS WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS Вопросы современной педиатрии дети ювенильный идиопатический артрит лечение абатацепт метотрексат |
| title | EFFICACY AND SAFETY OF COMBINATION TREATMENT WITH ABATACEPT AND METHOTREXATE AND MONOTHERAPY WITH METHOTREXATE IN PATIENTS WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS |
| title_full | EFFICACY AND SAFETY OF COMBINATION TREATMENT WITH ABATACEPT AND METHOTREXATE AND MONOTHERAPY WITH METHOTREXATE IN PATIENTS WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS |
| title_fullStr | EFFICACY AND SAFETY OF COMBINATION TREATMENT WITH ABATACEPT AND METHOTREXATE AND MONOTHERAPY WITH METHOTREXATE IN PATIENTS WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS |
| title_full_unstemmed | EFFICACY AND SAFETY OF COMBINATION TREATMENT WITH ABATACEPT AND METHOTREXATE AND MONOTHERAPY WITH METHOTREXATE IN PATIENTS WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS |
| title_short | EFFICACY AND SAFETY OF COMBINATION TREATMENT WITH ABATACEPT AND METHOTREXATE AND MONOTHERAPY WITH METHOTREXATE IN PATIENTS WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS |
| title_sort | efficacy and safety of combination treatment with abatacept and methotrexate and monotherapy with methotrexate in patients with polyarticular juvenile idiopathic arthritis |
| topic | дети ювенильный идиопатический артрит лечение абатацепт метотрексат |
| url | https://vsp.spr-journal.ru/jour/article/view/408 |
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