| Summary: | <i>Candida albicans</i> is an opportunistic pathogen involved in many infections, especially linked to implanted medical devices. Its ability to form biofilms complicates the treatment of these infections as few molecules are active against sessile <i>C. albicans</i>. The aim of this study was to evaluate the potential of leaves, three-month-old and one-year-old stems of <i>Rubus idaeus</i> L. against <i>C. albicans</i> biofilm growth. Extractions with a polarity gradient were carried out on hydroacetonic extracts and followed by fractionation steps. The obtained extracts and fractions were tested for their anti-biofilm growth activity against <i>C. albicans</i> using XTT method. Compounds of active subfractions were identified by LC-MS. The hexane extracts from leaves and stems were the most active against the fungus with IC<sub>50</sub> at 500 and 250 µg/mL. Their bioguided fractionation led to 4 subfractions with IC<sub>50</sub> between 62.5 and 125 µg/mL. Most of the components identified in active subfractions were fatty acids and terpenoïds.
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