Tubercular Mycobacterial Spindle Cell Pseudotumour: A Case Report
Pseudotumour is a benign inflammatory lesion. Mycobacterial spindle cell pseudotumour (MSP) is a rare pseudotumour. It is a benign proliferation of spindle-shaped histiocytes containing acid-fast mycobacterium, commonly reported in immunocompromised patients. MSP is usually associated with mycobacte...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2018-01-01
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| Series: | Iranian Journal of Medical Sciences |
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| Online Access: | http://ijms.sums.ac.ir/index.php/IJMS/article/view/3137 |
| _version_ | 1811206319057666048 |
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| author | Deba Prasad Dhibar Kamal Kant Sahu Surjit Singh Amanjit Bal Abhijit Chougale Varun Dhir |
| author_facet | Deba Prasad Dhibar Kamal Kant Sahu Surjit Singh Amanjit Bal Abhijit Chougale Varun Dhir |
| author_sort | Deba Prasad Dhibar |
| collection | DOAJ |
| description | Pseudotumour is a benign inflammatory lesion. Mycobacterial spindle cell pseudotumour (MSP) is a rare pseudotumour. It is a benign proliferation of spindle-shaped histiocytes containing acid-fast mycobacterium, commonly reported in immunocompromised patients. MSP is usually associated with mycobacterium avium complex (MAC). Here, we present the case of a 38-year-old gentleman with acquired immune deficiency syndrome (AIDS) who presented with low-grade fever for 1-month duration. Clinically, he had generalised lymphadenopathy. Chest X-ray showed miliary infiltration in bilateral lung fields. Lymph nodal biopsy showed spindle-shaped histiocytes filled with acid-fast bacilli on Ziehl-Neelsen (ZN) stain, suggestive of MSP. Immunohistochemical (IHC) stains were positive for CD68, S-100 and negative for CD31, which are consistent with MSP. Polymerase chain reaction (PCR) of the biopsy tissue was positive for MTB. Highly active antiretroviral therapy (HAART) was continued and anti-tubercular therapy (ATT) was started. The fever resolved within two weeks and there was a resolution of lymph nodal swelling by 6 weeks. The diagnosis of MSP associated with mycobacterium tuberculosis (MTB) makes our case interesting. It is of utmost importance to differentiate MSP from Kaposi’s sarcoma (KS) and other pseudotumours and to know whether it is of tubercular or non-tubercular origin, as the treatment is entirely different. |
| first_indexed | 2024-04-12T03:45:54Z |
| format | Article |
| id | doaj.art-9ab7ddf2eddd41369c21a158b5ffc5ef |
| institution | Directory Open Access Journal |
| issn | 0253-0716 1735-3688 |
| language | English |
| last_indexed | 2024-04-12T03:45:54Z |
| publishDate | 2018-01-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Sciences |
| spelling | doaj.art-9ab7ddf2eddd41369c21a158b5ffc5ef2022-12-22T03:49:08ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882018-01-014319496Tubercular Mycobacterial Spindle Cell Pseudotumour: A Case ReportDeba Prasad Dhibar0Kamal Kant Sahu1Surjit Singh2Amanjit Bal3Abhijit Chougale4Varun Dhir5Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaPseudotumour is a benign inflammatory lesion. Mycobacterial spindle cell pseudotumour (MSP) is a rare pseudotumour. It is a benign proliferation of spindle-shaped histiocytes containing acid-fast mycobacterium, commonly reported in immunocompromised patients. MSP is usually associated with mycobacterium avium complex (MAC). Here, we present the case of a 38-year-old gentleman with acquired immune deficiency syndrome (AIDS) who presented with low-grade fever for 1-month duration. Clinically, he had generalised lymphadenopathy. Chest X-ray showed miliary infiltration in bilateral lung fields. Lymph nodal biopsy showed spindle-shaped histiocytes filled with acid-fast bacilli on Ziehl-Neelsen (ZN) stain, suggestive of MSP. Immunohistochemical (IHC) stains were positive for CD68, S-100 and negative for CD31, which are consistent with MSP. Polymerase chain reaction (PCR) of the biopsy tissue was positive for MTB. Highly active antiretroviral therapy (HAART) was continued and anti-tubercular therapy (ATT) was started. The fever resolved within two weeks and there was a resolution of lymph nodal swelling by 6 weeks. The diagnosis of MSP associated with mycobacterium tuberculosis (MTB) makes our case interesting. It is of utmost importance to differentiate MSP from Kaposi’s sarcoma (KS) and other pseudotumours and to know whether it is of tubercular or non-tubercular origin, as the treatment is entirely different.http://ijms.sums.ac.ir/index.php/IJMS/article/view/3137Acquired immunodeficiency syndromeBiopsyMycobacterium tuberculosis (MTB)HIVSpindle cell |
| spellingShingle | Deba Prasad Dhibar Kamal Kant Sahu Surjit Singh Amanjit Bal Abhijit Chougale Varun Dhir Tubercular Mycobacterial Spindle Cell Pseudotumour: A Case Report Iranian Journal of Medical Sciences Acquired immunodeficiency syndrome Biopsy Mycobacterium tuberculosis (MTB) HIV Spindle cell |
| title | Tubercular Mycobacterial Spindle Cell Pseudotumour: A Case Report |
| title_full | Tubercular Mycobacterial Spindle Cell Pseudotumour: A Case Report |
| title_fullStr | Tubercular Mycobacterial Spindle Cell Pseudotumour: A Case Report |
| title_full_unstemmed | Tubercular Mycobacterial Spindle Cell Pseudotumour: A Case Report |
| title_short | Tubercular Mycobacterial Spindle Cell Pseudotumour: A Case Report |
| title_sort | tubercular mycobacterial spindle cell pseudotumour a case report |
| topic | Acquired immunodeficiency syndrome Biopsy Mycobacterium tuberculosis (MTB) HIV Spindle cell |
| url | http://ijms.sums.ac.ir/index.php/IJMS/article/view/3137 |
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