<i>CD147</i> rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican Population
Background: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical manifestations of COVID-19 range from mild flu-like symptoms to severe respiratory failure. Nowadays, extracellular matrix metalloproteinase inducer (EMMPRIN), also...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/8/1919 |
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| author | Luis M. Amezcua-Guerra Carlos A. Guzmán-Martín Isela Montúfar-Robles Rashidi Springall Adrián Hernández-Díazcouder Rosa Elda Barbosa-Cobos Fausto Sánchez-Muñoz Julián Ramírez-Bello |
| author_facet | Luis M. Amezcua-Guerra Carlos A. Guzmán-Martín Isela Montúfar-Robles Rashidi Springall Adrián Hernández-Díazcouder Rosa Elda Barbosa-Cobos Fausto Sánchez-Muñoz Julián Ramírez-Bello |
| author_sort | Luis M. Amezcua-Guerra |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical manifestations of COVID-19 range from mild flu-like symptoms to severe respiratory failure. Nowadays, extracellular matrix metalloproteinase inducer (EMMPRIN), also known as cluster of differentiation 147 (CD147) or BASIGIN, has been studied as enabling viral entry and replication within host cells. However, the impact of the <i>CD147</i> rs8259T>A single nucleotide variant (SNV) on SARS-CoV-2 susceptibility remains poorly investigated. Objective: To investigate the impact of rs8259T>A on the <i>CD147</i> gene in individuals from Mexico with COVID-19 disease. Methods: We genotyped the <i>CD147</i> rs8359T>A SNV in 195 patients with COVID-19 and 185 healthy controls from Mexico. In addition, we also measured the expression levels of CD147 and TNF mRNA and miR-492 from whole blood of patients with COVID-19 through RT-q-PCR. Results: We observed a significant association between the <i>CD147</i> rs8259T>A SNV and susceptibility to COVID-19: T vs. A; OR 1.36, 95% CI 1.02–1.81; <i>p</i> = 0.037; and TT vs. AA; OR 1.77, 95% CI 1.01–3.09; <i>p</i> = 0.046. On the other hand, we did not find differences in CD147, TNF or miR-492 expression levels when considering the genotypes of the <i>CD147</i> rs8259T>A SNV. Conclusions: Our results suggest that the <i>CD147</i> rs8259T>A variant is a risk factor for COVID-19. |
| first_indexed | 2024-03-10T23:43:49Z |
| format | Article |
| id | doaj.art-9ab7e3235489408aa85a4530d8b0a232 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T23:43:49Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-9ab7e3235489408aa85a4530d8b0a2322023-11-19T02:16:03ZengMDPI AGMicroorganisms2076-26072023-07-01118191910.3390/microorganisms11081919<i>CD147</i> rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican PopulationLuis M. Amezcua-Guerra0Carlos A. Guzmán-Martín1Isela Montúfar-Robles2Rashidi Springall3Adrián Hernández-Díazcouder4Rosa Elda Barbosa-Cobos5Fausto Sánchez-Muñoz6Julián Ramírez-Bello7Immunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoPostgraduate Doctoral Program in Biological and Health Sciences, Universidad Autónoma Metropolitana, Mexico City 14387, MexicoResearch Unit, Hospital Juárez de México, Mexico City 07760, MexicoImmunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoObesity and Asthma Research Laboratory, Hospital Infantil de México Federico Gómez, Mexico City 06720, MexicoRheumatology Department, Hospital Juárez de México, Mexico City 07760, MexicoImmunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoEndocrinology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoBackground: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical manifestations of COVID-19 range from mild flu-like symptoms to severe respiratory failure. Nowadays, extracellular matrix metalloproteinase inducer (EMMPRIN), also known as cluster of differentiation 147 (CD147) or BASIGIN, has been studied as enabling viral entry and replication within host cells. However, the impact of the <i>CD147</i> rs8259T>A single nucleotide variant (SNV) on SARS-CoV-2 susceptibility remains poorly investigated. Objective: To investigate the impact of rs8259T>A on the <i>CD147</i> gene in individuals from Mexico with COVID-19 disease. Methods: We genotyped the <i>CD147</i> rs8359T>A SNV in 195 patients with COVID-19 and 185 healthy controls from Mexico. In addition, we also measured the expression levels of CD147 and TNF mRNA and miR-492 from whole blood of patients with COVID-19 through RT-q-PCR. Results: We observed a significant association between the <i>CD147</i> rs8259T>A SNV and susceptibility to COVID-19: T vs. A; OR 1.36, 95% CI 1.02–1.81; <i>p</i> = 0.037; and TT vs. AA; OR 1.77, 95% CI 1.01–3.09; <i>p</i> = 0.046. On the other hand, we did not find differences in CD147, TNF or miR-492 expression levels when considering the genotypes of the <i>CD147</i> rs8259T>A SNV. Conclusions: Our results suggest that the <i>CD147</i> rs8259T>A variant is a risk factor for COVID-19.https://www.mdpi.com/2076-2607/11/8/1919CD147Basiginsingle nucleotide polymorphismrs8259COVID-19 |
| spellingShingle | Luis M. Amezcua-Guerra Carlos A. Guzmán-Martín Isela Montúfar-Robles Rashidi Springall Adrián Hernández-Díazcouder Rosa Elda Barbosa-Cobos Fausto Sánchez-Muñoz Julián Ramírez-Bello <i>CD147</i> rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican Population Microorganisms CD147 Basigin single nucleotide polymorphism rs8259 COVID-19 |
| title | <i>CD147</i> rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican Population |
| title_full | <i>CD147</i> rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican Population |
| title_fullStr | <i>CD147</i> rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican Population |
| title_full_unstemmed | <i>CD147</i> rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican Population |
| title_short | <i>CD147</i> rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican Population |
| title_sort | i cd147 i rs8259t a variant confers susceptibility to covid 19 infection within the mexican population |
| topic | CD147 Basigin single nucleotide polymorphism rs8259 COVID-19 |
| url | https://www.mdpi.com/2076-2607/11/8/1919 |
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