Native T1 mapping for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma: a pilot study
Abstract Background Previous studies have indicated that T1 relaxation time could be utilized for the analysis of tissue characteristics. T1 mapping technology has been gradually used on research of body tumor. In this study, the application of native T1 relaxation time for differentiating the histo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Cancer Imaging |
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| Online Access: | https://doi.org/10.1186/s40644-022-00461-7 |
| _version_ | 1828725687090937856 |
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| author | Juan Li Xuemei Gao Marcel Dominik Nickel Jingliang Cheng Jinxia Zhu |
| author_facet | Juan Li Xuemei Gao Marcel Dominik Nickel Jingliang Cheng Jinxia Zhu |
| author_sort | Juan Li |
| collection | DOAJ |
| description | Abstract Background Previous studies have indicated that T1 relaxation time could be utilized for the analysis of tissue characteristics. T1 mapping technology has been gradually used on research of body tumor. In this study, the application of native T1 relaxation time for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma was investigated. Methods One hundred and twenty patients with pathologically confirmed rectal adenocarcinoma were retrospectively evaluated. All patients underwent high-resolution anatomical magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and T1 mapping sequences. Parameters of T1 relaxation time and apparent diffusion coefficient (ADC) were measured between the different groups. The diagnostic power was evaluated though the receiver operating characteristic (ROC) curve. Results The T1 and ADC values varied significantly between rectal mucinous adenocarcinoma (MC) and non-mucinous rectal adenocarcinoma (AC) ([1986.1 ± 163.3 ms] vs. [1562.3 ± 244.2 ms] and [1.38 ± 0.23 × 10−3mm2/s] vs. [1.03 ± 0.15 × 10−3mm2/s], respectively; P < 0.001). In the AC group, T1 relaxation time were significantly different between the low- and high-grade adenocarcinoma cases ([1508.7 ± 188.6 ms] vs. [1806.5 ± 317.5 ms], P < 0.001), while no differences were apparent in the ADC values ([1.03 ± 0.14 × 10−3mm2/s] vs. [1.04 ± 0.18 × 10−3mm2/s], P > 0.05). No significant differences in T1 and ADC values were identified between the different T and N stage groups for both MC and AC (all P > 0.05). Conclusions Native T1 relaxation time can be used to discriminate MC from AC. The T1 relaxation time was helpful for differentiating the low- and high-grade of AC. |
| first_indexed | 2024-04-12T13:31:18Z |
| format | Article |
| id | doaj.art-9ab897cefca543e7b341d9be8b25bbbb |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-04-12T13:31:18Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-9ab897cefca543e7b341d9be8b25bbbb2022-12-22T03:31:10ZengBMCCancer Imaging1470-73302022-06-012211910.1186/s40644-022-00461-7Native T1 mapping for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma: a pilot studyJuan Li0Xuemei Gao1Marcel Dominik Nickel2Jingliang Cheng3Jinxia Zhu4Department of MRI, the First Affiliated Hospital of Zhengzhou UniversityDepartment of MRI, the First Affiliated Hospital of Zhengzhou UniversitySiemens Healthcare GmbHDepartment of MRI, the First Affiliated Hospital of Zhengzhou UniversityMR Collaboration, Siemens Healthcare LtdAbstract Background Previous studies have indicated that T1 relaxation time could be utilized for the analysis of tissue characteristics. T1 mapping technology has been gradually used on research of body tumor. In this study, the application of native T1 relaxation time for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma was investigated. Methods One hundred and twenty patients with pathologically confirmed rectal adenocarcinoma were retrospectively evaluated. All patients underwent high-resolution anatomical magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and T1 mapping sequences. Parameters of T1 relaxation time and apparent diffusion coefficient (ADC) were measured between the different groups. The diagnostic power was evaluated though the receiver operating characteristic (ROC) curve. Results The T1 and ADC values varied significantly between rectal mucinous adenocarcinoma (MC) and non-mucinous rectal adenocarcinoma (AC) ([1986.1 ± 163.3 ms] vs. [1562.3 ± 244.2 ms] and [1.38 ± 0.23 × 10−3mm2/s] vs. [1.03 ± 0.15 × 10−3mm2/s], respectively; P < 0.001). In the AC group, T1 relaxation time were significantly different between the low- and high-grade adenocarcinoma cases ([1508.7 ± 188.6 ms] vs. [1806.5 ± 317.5 ms], P < 0.001), while no differences were apparent in the ADC values ([1.03 ± 0.14 × 10−3mm2/s] vs. [1.04 ± 0.18 × 10−3mm2/s], P > 0.05). No significant differences in T1 and ADC values were identified between the different T and N stage groups for both MC and AC (all P > 0.05). Conclusions Native T1 relaxation time can be used to discriminate MC from AC. The T1 relaxation time was helpful for differentiating the low- and high-grade of AC.https://doi.org/10.1186/s40644-022-00461-7T1 mapping; Rectal neoplasmsAdenocarcinomaMagnetic resonance imaging |
| spellingShingle | Juan Li Xuemei Gao Marcel Dominik Nickel Jingliang Cheng Jinxia Zhu Native T1 mapping for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma: a pilot study Cancer Imaging T1 mapping; Rectal neoplasms Adenocarcinoma Magnetic resonance imaging |
| title | Native T1 mapping for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma: a pilot study |
| title_full | Native T1 mapping for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma: a pilot study |
| title_fullStr | Native T1 mapping for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma: a pilot study |
| title_full_unstemmed | Native T1 mapping for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma: a pilot study |
| title_short | Native T1 mapping for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma: a pilot study |
| title_sort | native t1 mapping for differentiating the histopathologic type grade and stage of rectal adenocarcinoma a pilot study |
| topic | T1 mapping; Rectal neoplasms Adenocarcinoma Magnetic resonance imaging |
| url | https://doi.org/10.1186/s40644-022-00461-7 |
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