Classification of positive surgical margins and tumor recurrence after nephron-sparing surgery for small renal masses
Gang Li,1,* Dong-Sheng Zhu,1,* Zhi-Qiang Lang,2 Ai-Xiang Wang,3 Yu-Hong Li,4 Ren-Ya Zhang,5 Yuan-Jie Niu1 1Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China; 2Department of Pathology, Yuhuangding Hospital of Qingdao Universi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-12-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/classification-of-positive-surgical-margins-and-tumor-recurrence-after-peer-reviewed-article-CMAR |
| _version_ | 1818994811094433792 |
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| author | Li G Zhu DS Lang ZQ Wang AX Li YH Zhang RY Niu YJ |
| author_facet | Li G Zhu DS Lang ZQ Wang AX Li YH Zhang RY Niu YJ |
| author_sort | Li G |
| collection | DOAJ |
| description | Gang Li,1,* Dong-Sheng Zhu,1,* Zhi-Qiang Lang,2 Ai-Xiang Wang,3 Yu-Hong Li,4 Ren-Ya Zhang,5 Yuan-Jie Niu1 1Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China; 2Department of Pathology, Yuhuangding Hospital of Qingdao University, Yantai 264000, China; 3Department of Pathology, Tianjin Institute of Urology, Tianjin 300211, China; 4Department of Pathology, The People’s Hospital of Liaocheng, Liaocheng 252000, China; 5Department of Pathology, Affiliated Hospital of Jining Medical University, Jining 272029, China *These authors are co-first authors Background: The association of positive margin and local recurrence after nephron-sparing surgery (NSS) remains a notably controversial issue. The aim of the present study was to investigate the relationship between classification of positive surgical margins (PSMs) and tumor recurrence based pathological findings.Methods: Clinical, pathological, and follow-up data of 600 small renal cancer patients who underwent NSS between November 2007 and November 2017 at four hospitals in China were analyzed retrospectively.Results: Of the 600 reviewed patients, 20 had positive margins. During the follow-up period of 56 months, only three cases of tumor recurrence were identified. Pathological examination was performed, and subsequently a new classification criteria were proposed: 1) False PSMs, which could be further divided into three subtypes: i) no standard processing performed on pathological specimens (seven patients); ii) incidental incision into the tumor during operation, with the tumor bed free of tumor residues (four patients); iii) part of the tumor pseudocapsule was noted to be remained in the tumor bed, with no signs of tumor residue (four patients). 2) True PSMs with two subtypes: i) a large number of residual tumor cells at the surgical margin (three patients); ii) incision of satellite tumor nodules detected around a large tumor (two patients).Conclusion: Taken together, PSMs in NSS were rarely found. Based on the pathological examination findings, PSMs can be divided into false positive and true positive. This being said, PSMs were determined to be poor predictors for local recurrence, with no predominant association with true tumor remnants in the majority of our evaluated cases. Through the key findings of our study, we concluded that PSMs should be carefully analyzed and treated on a case-by-case basis. Keywords: small renal masses, positive surgical margins, nephron-sparing surgery, recurrence |
| first_indexed | 2024-12-20T21:03:52Z |
| format | Article |
| id | doaj.art-9abb8972787d465185200ad5f93926cb |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-20T21:03:52Z |
| publishDate | 2018-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-9abb8972787d465185200ad5f93926cb2022-12-21T19:26:39ZengDove Medical PressCancer Management and Research1179-13222018-12-01Volume 106591659842776Classification of positive surgical margins and tumor recurrence after nephron-sparing surgery for small renal massesLi GZhu DSLang ZQWang AXLi YHZhang RYNiu YJGang Li,1,* Dong-Sheng Zhu,1,* Zhi-Qiang Lang,2 Ai-Xiang Wang,3 Yu-Hong Li,4 Ren-Ya Zhang,5 Yuan-Jie Niu1 1Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China; 2Department of Pathology, Yuhuangding Hospital of Qingdao University, Yantai 264000, China; 3Department of Pathology, Tianjin Institute of Urology, Tianjin 300211, China; 4Department of Pathology, The People’s Hospital of Liaocheng, Liaocheng 252000, China; 5Department of Pathology, Affiliated Hospital of Jining Medical University, Jining 272029, China *These authors are co-first authors Background: The association of positive margin and local recurrence after nephron-sparing surgery (NSS) remains a notably controversial issue. The aim of the present study was to investigate the relationship between classification of positive surgical margins (PSMs) and tumor recurrence based pathological findings.Methods: Clinical, pathological, and follow-up data of 600 small renal cancer patients who underwent NSS between November 2007 and November 2017 at four hospitals in China were analyzed retrospectively.Results: Of the 600 reviewed patients, 20 had positive margins. During the follow-up period of 56 months, only three cases of tumor recurrence were identified. Pathological examination was performed, and subsequently a new classification criteria were proposed: 1) False PSMs, which could be further divided into three subtypes: i) no standard processing performed on pathological specimens (seven patients); ii) incidental incision into the tumor during operation, with the tumor bed free of tumor residues (four patients); iii) part of the tumor pseudocapsule was noted to be remained in the tumor bed, with no signs of tumor residue (four patients). 2) True PSMs with two subtypes: i) a large number of residual tumor cells at the surgical margin (three patients); ii) incision of satellite tumor nodules detected around a large tumor (two patients).Conclusion: Taken together, PSMs in NSS were rarely found. Based on the pathological examination findings, PSMs can be divided into false positive and true positive. This being said, PSMs were determined to be poor predictors for local recurrence, with no predominant association with true tumor remnants in the majority of our evaluated cases. Through the key findings of our study, we concluded that PSMs should be carefully analyzed and treated on a case-by-case basis. Keywords: small renal masses, positive surgical margins, nephron-sparing surgery, recurrencehttps://www.dovepress.com/classification-of-positive-surgical-margins-and-tumor-recurrence-after-peer-reviewed-article-CMARSmall renal massesPositive surgical marginsNephron-sparing surgeryRecurrence |
| spellingShingle | Li G Zhu DS Lang ZQ Wang AX Li YH Zhang RY Niu YJ Classification of positive surgical margins and tumor recurrence after nephron-sparing surgery for small renal masses Cancer Management and Research Small renal masses Positive surgical margins Nephron-sparing surgery Recurrence |
| title | Classification of positive surgical margins and tumor recurrence after nephron-sparing surgery for small renal masses |
| title_full | Classification of positive surgical margins and tumor recurrence after nephron-sparing surgery for small renal masses |
| title_fullStr | Classification of positive surgical margins and tumor recurrence after nephron-sparing surgery for small renal masses |
| title_full_unstemmed | Classification of positive surgical margins and tumor recurrence after nephron-sparing surgery for small renal masses |
| title_short | Classification of positive surgical margins and tumor recurrence after nephron-sparing surgery for small renal masses |
| title_sort | classification of positive surgical margins and tumor recurrence after nephron sparing surgery for small renal masses |
| topic | Small renal masses Positive surgical margins Nephron-sparing surgery Recurrence |
| url | https://www.dovepress.com/classification-of-positive-surgical-margins-and-tumor-recurrence-after-peer-reviewed-article-CMAR |
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