Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study
In a population-based study in the Netherlands, diphtheria antitoxin antibodies were measured with a toxin-binding inhibition assay in 9,134 sera from the general population and religious communities refusing vaccination. The Dutch immunization program appears to induce long-term protection against...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
1999-10-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/5/5/99-0511_article |
| _version_ | 1819087470546911232 |
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| author | Hester E. de Melker G.A.M. Berbers N.J.D. Nagelkerke M.A.E. Conyn-van Spaendonck |
| author_facet | Hester E. de Melker G.A.M. Berbers N.J.D. Nagelkerke M.A.E. Conyn-van Spaendonck |
| author_sort | Hester E. de Melker |
| collection | DOAJ |
| description | In a population-based study in the Netherlands, diphtheria antitoxin antibodies were measured with a toxin-binding inhibition assay in 9,134 sera from the general population and religious communities refusing vaccination. The Dutch immunization program appears to induce long-term protection against diphtheria. However, a substantial number of adults born before the program was introduced had no protective diphtheria antibody levels. Although herd immunity seems adequate, long-term population protection cannot be assured. As more than 60% of orthodox reformed persons have antibody levels lower than 0.01 IU/ml, introduction of diphtheria into religious communities refusing vaccination may constitute a danger of spread of the bacterium. |
| first_indexed | 2024-12-21T21:36:39Z |
| format | Article |
| id | doaj.art-9abd05a4b69e4182b7d9051ce4b413f1 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-21T21:36:39Z |
| publishDate | 1999-10-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-9abd05a4b69e4182b7d9051ce4b413f12022-12-21T18:49:29ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60591999-10-015569470010.3201/eid0505.990511Diphtheria Antitoxin Levels in the Netherlands: a Population-Based StudyHester E. de MelkerG.A.M. BerbersN.J.D. NagelkerkeM.A.E. Conyn-van SpaendonckIn a population-based study in the Netherlands, diphtheria antitoxin antibodies were measured with a toxin-binding inhibition assay in 9,134 sera from the general population and religious communities refusing vaccination. The Dutch immunization program appears to induce long-term protection against diphtheria. However, a substantial number of adults born before the program was introduced had no protective diphtheria antibody levels. Although herd immunity seems adequate, long-term population protection cannot be assured. As more than 60% of orthodox reformed persons have antibody levels lower than 0.01 IU/ml, introduction of diphtheria into religious communities refusing vaccination may constitute a danger of spread of the bacterium.https://wwwnc.cdc.gov/eid/article/5/5/99-0511_articlethe Netherlands |
| spellingShingle | Hester E. de Melker G.A.M. Berbers N.J.D. Nagelkerke M.A.E. Conyn-van Spaendonck Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study Emerging Infectious Diseases the Netherlands |
| title | Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study |
| title_full | Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study |
| title_fullStr | Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study |
| title_full_unstemmed | Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study |
| title_short | Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study |
| title_sort | diphtheria antitoxin levels in the netherlands a population based study |
| topic | the Netherlands |
| url | https://wwwnc.cdc.gov/eid/article/5/5/99-0511_article |
| work_keys_str_mv | AT hesteredemelker diphtheriaantitoxinlevelsinthenetherlandsapopulationbasedstudy AT gamberbers diphtheriaantitoxinlevelsinthenetherlandsapopulationbasedstudy AT njdnagelkerke diphtheriaantitoxinlevelsinthenetherlandsapopulationbasedstudy AT maeconynvanspaendonck diphtheriaantitoxinlevelsinthenetherlandsapopulationbasedstudy |