A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies

A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies

The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a NRF2 activity metric and utilized it to conduct a pan-cancer analysis of oncogenic NRF2 signaling. We identified an immunoe...

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Bibliographic Details
Main Authors: Jouni Härkönen, Petri Pölönen, Ashik Jawahar Deen, Ilakya Selvarajan, Hanna-Riikka Teppo, Elitsa Y. Dimova, Thomas Kietzmann, Maarit Ahtiainen, Juha P. Väyrynen, Sara A. Väyrynen, Hanna Elomaa, Niko Tynkkynen, Tiia Eklund, Teijo Kuopio, Eva-Maria Talvitie, Pekka Taimen, Markku Kallajoki, Minna U. Kaikkonen, Merja Heinäniemi, Anna-Liisa Levonen
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Redox Biology
Subjects:
NRF2
KEAP1
Redox
Squamous
T cells
Interferon gamma
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000459

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