Association Between Serum Carnosinase Concentration and Activity and Renal Function Impairment in a Type-2 Diabetes Cohort
Introduction: Genetic studies have identified associations of carnosinase 1 (CN1) polymorphisms with diabetic kidney disease (DKD). However, CN1 levels and activities have not been assessed as diagnostic or prognostic markers of DKD in cohorts of patients with type 2 diabetes (T2D).Methods: We estab...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.899057/full |
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| author | Jiedong Qiu Jiedong Qiu Benito A. Yard Bernhard K. Krämer Harry van Goor Peter van Dijk Peter van Dijk Aimo Kannt Aimo Kannt |
| author_facet | Jiedong Qiu Jiedong Qiu Benito A. Yard Bernhard K. Krämer Harry van Goor Peter van Dijk Peter van Dijk Aimo Kannt Aimo Kannt |
| author_sort | Jiedong Qiu |
| collection | DOAJ |
| description | Introduction: Genetic studies have identified associations of carnosinase 1 (CN1) polymorphisms with diabetic kidney disease (DKD). However, CN1 levels and activities have not been assessed as diagnostic or prognostic markers of DKD in cohorts of patients with type 2 diabetes (T2D).Methods: We established high-throughput, automated CN1 activity and concentration assays using robotic systems. Using these methods, we determined baseline serum CN1 levels and activity in a T2D cohort with 970 patients with no or only mild renal impairment. The patients were followed for a mean of 1.2 years. Baseline serum CN1 concentration and activity were assessed as predictors of renal function impairment and incident albuminuria during follow up.Results: CN1 concentration was significantly associated with age, gender and estimated glomerular filtration rate (eGFR) at baseline. CN1 activity was significantly associated with glycated hemoglobin A1c (HbA1c) and eGFR. Serum CN1 at baseline was associated with eGFR decline and predicted renal function impairment and incident albuminuria during the follow-up.Discussion: Baseline serum CN1 levels were associated with presence and progression of renal function decline in a cohort of T2D patients. Confirmation in larger cohorts with longer follow-up observation periods will be required to fully establish CN1 as a biomarker of DKD. |
| first_indexed | 2024-04-13T14:33:58Z |
| format | Article |
| id | doaj.art-9ac196f3bfbe47e1aa2b1cb70ad4568f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T14:33:58Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-9ac196f3bfbe47e1aa2b1cb70ad4568f2022-12-22T02:43:05ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-07-011310.3389/fphar.2022.899057899057Association Between Serum Carnosinase Concentration and Activity and Renal Function Impairment in a Type-2 Diabetes CohortJiedong Qiu0Jiedong Qiu1Benito A. Yard2Bernhard K. Krämer3Harry van Goor4Peter van Dijk5Peter van Dijk6Aimo Kannt7Aimo Kannt85th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Pathology and Medical Biology, University Medical Centre Groningen and University of Groningen, Groningen, Netherlands5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Pathology and Medical Biology, University Medical Centre Groningen and University of Groningen, Groningen, NetherlandsDepartment of Endocrinology, University Medical Centre Groningen and University of Groningen, Groningen, NetherlandsIsala, Diabetes Centre, Zwolle, NetherlandsFraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, GermanyInstitute of Experimental Pharmacology, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyIntroduction: Genetic studies have identified associations of carnosinase 1 (CN1) polymorphisms with diabetic kidney disease (DKD). However, CN1 levels and activities have not been assessed as diagnostic or prognostic markers of DKD in cohorts of patients with type 2 diabetes (T2D).Methods: We established high-throughput, automated CN1 activity and concentration assays using robotic systems. Using these methods, we determined baseline serum CN1 levels and activity in a T2D cohort with 970 patients with no or only mild renal impairment. The patients were followed for a mean of 1.2 years. Baseline serum CN1 concentration and activity were assessed as predictors of renal function impairment and incident albuminuria during follow up.Results: CN1 concentration was significantly associated with age, gender and estimated glomerular filtration rate (eGFR) at baseline. CN1 activity was significantly associated with glycated hemoglobin A1c (HbA1c) and eGFR. Serum CN1 at baseline was associated with eGFR decline and predicted renal function impairment and incident albuminuria during the follow-up.Discussion: Baseline serum CN1 levels were associated with presence and progression of renal function decline in a cohort of T2D patients. Confirmation in larger cohorts with longer follow-up observation periods will be required to fully establish CN1 as a biomarker of DKD.https://www.frontiersin.org/articles/10.3389/fphar.2022.899057/fulldiabetic nephropathycarnosinehistidine-dipeptidasediabetic complicationscarnosinase |
| spellingShingle | Jiedong Qiu Jiedong Qiu Benito A. Yard Bernhard K. Krämer Harry van Goor Peter van Dijk Peter van Dijk Aimo Kannt Aimo Kannt Association Between Serum Carnosinase Concentration and Activity and Renal Function Impairment in a Type-2 Diabetes Cohort Frontiers in Pharmacology diabetic nephropathy carnosine histidine-dipeptidase diabetic complications carnosinase |
| title | Association Between Serum Carnosinase Concentration and Activity and Renal Function Impairment in a Type-2 Diabetes Cohort |
| title_full | Association Between Serum Carnosinase Concentration and Activity and Renal Function Impairment in a Type-2 Diabetes Cohort |
| title_fullStr | Association Between Serum Carnosinase Concentration and Activity and Renal Function Impairment in a Type-2 Diabetes Cohort |
| title_full_unstemmed | Association Between Serum Carnosinase Concentration and Activity and Renal Function Impairment in a Type-2 Diabetes Cohort |
| title_short | Association Between Serum Carnosinase Concentration and Activity and Renal Function Impairment in a Type-2 Diabetes Cohort |
| title_sort | association between serum carnosinase concentration and activity and renal function impairment in a type 2 diabetes cohort |
| topic | diabetic nephropathy carnosine histidine-dipeptidase diabetic complications carnosinase |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.899057/full |
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