Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios

Background: One of the vital variables affecting the stability and the characteristics of the Nanostructured Lipid Carrier (NLC) is the surfactant concentration. Using the two combinations of surfactants can cause higher stability and a better characteristic of NLC. Tween 80 and Span 20 are anionic...

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Main Authors: Dyah Rahmasari, Noorma Rosita, Widji Soeratri
Format: Article
Language:Indonesian
Published: Faculty of Pharmacy, Universitas Airlangga 2022-04-01
Series:Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Subjects:
Online Access:https://e-journal.unair.ac.id/JFIKI/article/view/26851/17578
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author Dyah Rahmasari
Noorma Rosita
Widji Soeratri
author_facet Dyah Rahmasari
Noorma Rosita
Widji Soeratri
author_sort Dyah Rahmasari
collection DOAJ
description Background: One of the vital variables affecting the stability and the characteristics of the Nanostructured Lipid Carrier (NLC) is the surfactant concentration. Using the two combinations of surfactants can cause higher stability and a better characteristic of NLC. Tween 80 and Span 20 are anionic surfactants whose combination has not been studied for use in NLC systems. Objective: Determine the effect of different surfactant ratios of Tween 80 and Span 20 on the physicochemical characteristics, stability, and irritability of NLC using the High Shear Homogenization (HSH) method. Methods: Four different surfactant ratios were used in the NLC formulation, in which the ratio of Tween 80:Span 20 were 5:5, 6:6, 7:7, and 8:8, respectively. In this NLC system, cetyl palmitate served as solid lipid, medium-chain triglyceride (CrodamolTM) as liquid lipid, Tween 80, and Span 20 as surfactant components. NLC was characterized for organoleptic, viscosity, pH, zeta potential, particle morphology, particle size, and polydispersity index (PDI), then evaluated for stability using the real-time and freeze-thaw method, and irritability effect. Results: The different ratios of Tween 80 and Span 20 had no significant effect on the particle size, PI, and irritation score of the NLC system. On the other hand, it influenced all formulas' pH value, viscosity, zeta potential, and stability. Conclusions: The different ratios of surfactant combination affect the characteristics and stability of the NLC system.
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spelling doaj.art-9ac26bb413fb44cfb8423307aa6c2d942022-12-22T00:45:50ZindFaculty of Pharmacy, Universitas AirlanggaJurnal Farmasi dan Ilmu Kefarmasian Indonesia2406-93882580-83032022-04-019181610.20473/jfiki.v9i12022.8-16Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant RatiosDyah Rahmasari0Noorma Rosita1Widji Soeratri2Department of Pharmacy, Faculty of Health Science, Universitas Muhammadiyah Malang, Malang, IndonesiaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, IndonesiaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, IndonesiaBackground: One of the vital variables affecting the stability and the characteristics of the Nanostructured Lipid Carrier (NLC) is the surfactant concentration. Using the two combinations of surfactants can cause higher stability and a better characteristic of NLC. Tween 80 and Span 20 are anionic surfactants whose combination has not been studied for use in NLC systems. Objective: Determine the effect of different surfactant ratios of Tween 80 and Span 20 on the physicochemical characteristics, stability, and irritability of NLC using the High Shear Homogenization (HSH) method. Methods: Four different surfactant ratios were used in the NLC formulation, in which the ratio of Tween 80:Span 20 were 5:5, 6:6, 7:7, and 8:8, respectively. In this NLC system, cetyl palmitate served as solid lipid, medium-chain triglyceride (CrodamolTM) as liquid lipid, Tween 80, and Span 20 as surfactant components. NLC was characterized for organoleptic, viscosity, pH, zeta potential, particle morphology, particle size, and polydispersity index (PDI), then evaluated for stability using the real-time and freeze-thaw method, and irritability effect. Results: The different ratios of Tween 80 and Span 20 had no significant effect on the particle size, PI, and irritation score of the NLC system. On the other hand, it influenced all formulas' pH value, viscosity, zeta potential, and stability. Conclusions: The different ratios of surfactant combination affect the characteristics and stability of the NLC system.https://e-journal.unair.ac.id/JFIKI/article/view/26851/17578irritabilitynlcphysicochemical characterizationstabilitysurfactant ratios
spellingShingle Dyah Rahmasari
Noorma Rosita
Widji Soeratri
Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
irritability
nlc
physicochemical characterization
stability
surfactant ratios
title Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios
title_full Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios
title_fullStr Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios
title_full_unstemmed Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios
title_short Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios
title_sort physicochemical characteristics stability and irritability of nanostructured lipid carrier system stabilized with different surfactant ratios
topic irritability
nlc
physicochemical characterization
stability
surfactant ratios
url https://e-journal.unair.ac.id/JFIKI/article/view/26851/17578
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AT noormarosita physicochemicalcharacteristicsstabilityandirritabilityofnanostructuredlipidcarriersystemstabilizedwithdifferentsurfactantratios
AT widjisoeratri physicochemicalcharacteristicsstabilityandirritabilityofnanostructuredlipidcarriersystemstabilizedwithdifferentsurfactantratios