Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios
Background: One of the vital variables affecting the stability and the characteristics of the Nanostructured Lipid Carrier (NLC) is the surfactant concentration. Using the two combinations of surfactants can cause higher stability and a better characteristic of NLC. Tween 80 and Span 20 are anionic...
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Format: | Article |
Language: | Indonesian |
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Faculty of Pharmacy, Universitas Airlangga
2022-04-01
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Series: | Jurnal Farmasi dan Ilmu Kefarmasian Indonesia |
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Online Access: | https://e-journal.unair.ac.id/JFIKI/article/view/26851/17578 |
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author | Dyah Rahmasari Noorma Rosita Widji Soeratri |
author_facet | Dyah Rahmasari Noorma Rosita Widji Soeratri |
author_sort | Dyah Rahmasari |
collection | DOAJ |
description | Background: One of the vital variables affecting the stability and the characteristics of the Nanostructured Lipid Carrier (NLC) is the surfactant concentration. Using the two combinations of surfactants can cause higher stability and a better characteristic of NLC. Tween 80 and Span 20 are anionic surfactants whose combination has not been studied for use in NLC systems. Objective: Determine the effect of different surfactant ratios of Tween 80 and Span 20 on the physicochemical characteristics, stability, and irritability of NLC using the High Shear Homogenization (HSH) method. Methods: Four different surfactant ratios were used in the NLC formulation, in which the ratio of Tween 80:Span 20 were 5:5, 6:6, 7:7, and 8:8, respectively. In this NLC system, cetyl palmitate served as solid lipid, medium-chain triglyceride (CrodamolTM) as liquid lipid, Tween 80, and Span 20 as surfactant components. NLC was characterized for organoleptic, viscosity, pH, zeta potential, particle morphology, particle size, and polydispersity index (PDI), then evaluated for stability using the real-time and freeze-thaw method, and irritability effect. Results: The different ratios of Tween 80 and Span 20 had no significant effect on the particle size, PI, and irritation score of the NLC system. On the other hand, it influenced all formulas' pH value, viscosity, zeta potential, and stability. Conclusions: The different ratios of surfactant combination affect the characteristics and stability of the NLC system. |
first_indexed | 2024-12-11T23:37:04Z |
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issn | 2406-9388 2580-8303 |
language | Indonesian |
last_indexed | 2024-12-11T23:37:04Z |
publishDate | 2022-04-01 |
publisher | Faculty of Pharmacy, Universitas Airlangga |
record_format | Article |
series | Jurnal Farmasi dan Ilmu Kefarmasian Indonesia |
spelling | doaj.art-9ac26bb413fb44cfb8423307aa6c2d942022-12-22T00:45:50ZindFaculty of Pharmacy, Universitas AirlanggaJurnal Farmasi dan Ilmu Kefarmasian Indonesia2406-93882580-83032022-04-019181610.20473/jfiki.v9i12022.8-16Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant RatiosDyah Rahmasari0Noorma Rosita1Widji Soeratri2Department of Pharmacy, Faculty of Health Science, Universitas Muhammadiyah Malang, Malang, IndonesiaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, IndonesiaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, IndonesiaBackground: One of the vital variables affecting the stability and the characteristics of the Nanostructured Lipid Carrier (NLC) is the surfactant concentration. Using the two combinations of surfactants can cause higher stability and a better characteristic of NLC. Tween 80 and Span 20 are anionic surfactants whose combination has not been studied for use in NLC systems. Objective: Determine the effect of different surfactant ratios of Tween 80 and Span 20 on the physicochemical characteristics, stability, and irritability of NLC using the High Shear Homogenization (HSH) method. Methods: Four different surfactant ratios were used in the NLC formulation, in which the ratio of Tween 80:Span 20 were 5:5, 6:6, 7:7, and 8:8, respectively. In this NLC system, cetyl palmitate served as solid lipid, medium-chain triglyceride (CrodamolTM) as liquid lipid, Tween 80, and Span 20 as surfactant components. NLC was characterized for organoleptic, viscosity, pH, zeta potential, particle morphology, particle size, and polydispersity index (PDI), then evaluated for stability using the real-time and freeze-thaw method, and irritability effect. Results: The different ratios of Tween 80 and Span 20 had no significant effect on the particle size, PI, and irritation score of the NLC system. On the other hand, it influenced all formulas' pH value, viscosity, zeta potential, and stability. Conclusions: The different ratios of surfactant combination affect the characteristics and stability of the NLC system.https://e-journal.unair.ac.id/JFIKI/article/view/26851/17578irritabilitynlcphysicochemical characterizationstabilitysurfactant ratios |
spellingShingle | Dyah Rahmasari Noorma Rosita Widji Soeratri Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios Jurnal Farmasi dan Ilmu Kefarmasian Indonesia irritability nlc physicochemical characterization stability surfactant ratios |
title | Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios |
title_full | Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios |
title_fullStr | Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios |
title_full_unstemmed | Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios |
title_short | Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios |
title_sort | physicochemical characteristics stability and irritability of nanostructured lipid carrier system stabilized with different surfactant ratios |
topic | irritability nlc physicochemical characterization stability surfactant ratios |
url | https://e-journal.unair.ac.id/JFIKI/article/view/26851/17578 |
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