Age-associated network controllability changes in first episode drug-naïve schizophrenia
Abstract Background Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations in the brain’s structural connectivity lead to dynamic function changes in schi...
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-021-03674-5 |
| _version_ | 1819008494706098176 |
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| author | Biqiu Tang Wenjing Zhang Shikuang Deng Jiang Liu Na Hu Qiyong Gong Shi Gu Su Lui |
| author_facet | Biqiu Tang Wenjing Zhang Shikuang Deng Jiang Liu Na Hu Qiyong Gong Shi Gu Su Lui |
| author_sort | Biqiu Tang |
| collection | DOAJ |
| description | Abstract Background Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations in the brain’s structural connectivity lead to dynamic function changes in schizophrenia with age remains poorly understood. Methods Combining structural magnetic resonance imaging and a network control theory approach, the white matter network controllability metric (average controllability) was mapped from age 16 to 60 years in 175 drug-naïve schizophrenia patients and 155 matched healthy controls. Results Compared with controls, the schizophrenia patients demonstrated the lack of age-related decrease on average controllability of default mode network (DMN), as well as the right precuneus (a hub region of DMN), suggesting abnormal maturational development process in schizophrenia. Interestingly, the schizophrenia patients demonstrated an accelerated age-related decline of average controllability in the subcortical network, supporting the neurodegenerative model. In addition, compared with controls, the lack of age-related increase on average controllability of the left inferior parietal gyrus in schizophrenia patients also suggested a different pathway of brain development. Conclusions By applying the control theory approach, the present study revealed age-related changes in the ability of white matter pathways to control functional activity states in schizophrenia. The findings supported both the developmental and degenerative hypotheses of schizophrenia, and suggested a particularly high vulnerability of the DMN and subcortical network possibly reflecting an illness-related early marker for the disorder. |
| first_indexed | 2024-12-21T00:41:22Z |
| format | Article |
| id | doaj.art-9ac49271d2114ad8a60f807cb1587da8 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-21T00:41:22Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-9ac49271d2114ad8a60f807cb1587da82022-12-21T19:21:40ZengBMCBMC Psychiatry1471-244X2022-01-012211910.1186/s12888-021-03674-5Age-associated network controllability changes in first episode drug-naïve schizophreniaBiqiu Tang0Wenjing Zhang1Shikuang Deng2Jiang Liu3Na Hu4Qiyong Gong5Shi Gu6Su Lui7Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan UniversitySchool of Computer Science and Engineering, University of Electronic Science and Technology of ChinaSchool of Computer Science and Engineering, University of Electronic Science and Technology of ChinaHuaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan UniversitySchool of Computer Science and Engineering, University of Electronic Science and Technology of ChinaHuaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan UniversityAbstract Background Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations in the brain’s structural connectivity lead to dynamic function changes in schizophrenia with age remains poorly understood. Methods Combining structural magnetic resonance imaging and a network control theory approach, the white matter network controllability metric (average controllability) was mapped from age 16 to 60 years in 175 drug-naïve schizophrenia patients and 155 matched healthy controls. Results Compared with controls, the schizophrenia patients demonstrated the lack of age-related decrease on average controllability of default mode network (DMN), as well as the right precuneus (a hub region of DMN), suggesting abnormal maturational development process in schizophrenia. Interestingly, the schizophrenia patients demonstrated an accelerated age-related decline of average controllability in the subcortical network, supporting the neurodegenerative model. In addition, compared with controls, the lack of age-related increase on average controllability of the left inferior parietal gyrus in schizophrenia patients also suggested a different pathway of brain development. Conclusions By applying the control theory approach, the present study revealed age-related changes in the ability of white matter pathways to control functional activity states in schizophrenia. The findings supported both the developmental and degenerative hypotheses of schizophrenia, and suggested a particularly high vulnerability of the DMN and subcortical network possibly reflecting an illness-related early marker for the disorder.https://doi.org/10.1186/s12888-021-03674-5SchizophreniaNetwork controllabilityFunctional dynamicsStructural connectivityAge-related changePsychoradiology |
| spellingShingle | Biqiu Tang Wenjing Zhang Shikuang Deng Jiang Liu Na Hu Qiyong Gong Shi Gu Su Lui Age-associated network controllability changes in first episode drug-naïve schizophrenia BMC Psychiatry Schizophrenia Network controllability Functional dynamics Structural connectivity Age-related change Psychoradiology |
| title | Age-associated network controllability changes in first episode drug-naïve schizophrenia |
| title_full | Age-associated network controllability changes in first episode drug-naïve schizophrenia |
| title_fullStr | Age-associated network controllability changes in first episode drug-naïve schizophrenia |
| title_full_unstemmed | Age-associated network controllability changes in first episode drug-naïve schizophrenia |
| title_short | Age-associated network controllability changes in first episode drug-naïve schizophrenia |
| title_sort | age associated network controllability changes in first episode drug naive schizophrenia |
| topic | Schizophrenia Network controllability Functional dynamics Structural connectivity Age-related change Psychoradiology |
| url | https://doi.org/10.1186/s12888-021-03674-5 |
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