TRPML1—Emerging Roles in Cancer
The mucolipin-1 (TRPML1) channel maintains lysosomal ionic homeostasis and regulates autophagic flux. Defects of TRPML1 lead to lysosomal storage diseases and neurodegeneration. In this report, we discuss emerging evidence pertaining to differential regulation of TRPML1 signaling pathways in cancer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/12/2682 |
| _version_ | 1797544828894969856 |
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| author | Yiming Yang Xingjian Zhai Yassine El Hiani |
| author_facet | Yiming Yang Xingjian Zhai Yassine El Hiani |
| author_sort | Yiming Yang |
| collection | DOAJ |
| description | The mucolipin-1 (TRPML1) channel maintains lysosomal ionic homeostasis and regulates autophagic flux. Defects of TRPML1 lead to lysosomal storage diseases and neurodegeneration. In this report, we discuss emerging evidence pertaining to differential regulation of TRPML1 signaling pathways in cancer progression with the goal of leveraging the oncogenic potential of TRPML1 to inspire therapeutic interventions. |
| first_indexed | 2024-03-10T14:06:04Z |
| format | Article |
| id | doaj.art-9ac60ac50cbf479b9af7d5e84bf272a5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:06:04Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9ac60ac50cbf479b9af7d5e84bf272a52023-11-21T00:38:26ZengMDPI AGCells2073-44092020-12-01912268210.3390/cells9122682TRPML1—Emerging Roles in CancerYiming Yang0Xingjian Zhai1Yassine El Hiani2Department of Physiology and Biophysics, Dalhousie University Faculty of Medicine, Halifax, NS B3H 4R2, CanadaDepartment of Physiology and Biophysics, Dalhousie University Faculty of Medicine, Halifax, NS B3H 4R2, CanadaDepartment of Physiology and Biophysics, Dalhousie University Faculty of Medicine, Halifax, NS B3H 4R2, CanadaThe mucolipin-1 (TRPML1) channel maintains lysosomal ionic homeostasis and regulates autophagic flux. Defects of TRPML1 lead to lysosomal storage diseases and neurodegeneration. In this report, we discuss emerging evidence pertaining to differential regulation of TRPML1 signaling pathways in cancer progression with the goal of leveraging the oncogenic potential of TRPML1 to inspire therapeutic interventions.https://www.mdpi.com/2073-4409/9/12/2682cancerlysosomesTRPML1mitochondria |
| spellingShingle | Yiming Yang Xingjian Zhai Yassine El Hiani TRPML1—Emerging Roles in Cancer Cells cancer lysosomes TRPML1 mitochondria |
| title | TRPML1—Emerging Roles in Cancer |
| title_full | TRPML1—Emerging Roles in Cancer |
| title_fullStr | TRPML1—Emerging Roles in Cancer |
| title_full_unstemmed | TRPML1—Emerging Roles in Cancer |
| title_short | TRPML1—Emerging Roles in Cancer |
| title_sort | trpml1 emerging roles in cancer |
| topic | cancer lysosomes TRPML1 mitochondria |
| url | https://www.mdpi.com/2073-4409/9/12/2682 |
| work_keys_str_mv | AT yimingyang trpml1emergingrolesincancer AT xingjianzhai trpml1emergingrolesincancer AT yassineelhiani trpml1emergingrolesincancer |