Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves
Spontaneous slow oscillation-associated slow wave activity represents an internally generated state which is characterized by alternations of network quiescence and stereotypical episodes of neuronal activity - slow wave events. However, it remains unclear which macroscopic signal is related to thes...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-09-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/27602 |
| _version_ | 1811253022431379456 |
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| author | Miriam Schwalm Florian Schmid Lydia Wachsmuth Hendrik Backhaus Andrea Kronfeld Felipe Aedo Jury Pierre-Hugues Prouvot Consuelo Fois Franziska Albers Timo van Alst Cornelius Faber Albrecht Stroh |
| author_facet | Miriam Schwalm Florian Schmid Lydia Wachsmuth Hendrik Backhaus Andrea Kronfeld Felipe Aedo Jury Pierre-Hugues Prouvot Consuelo Fois Franziska Albers Timo van Alst Cornelius Faber Albrecht Stroh |
| author_sort | Miriam Schwalm |
| collection | DOAJ |
| description | Spontaneous slow oscillation-associated slow wave activity represents an internally generated state which is characterized by alternations of network quiescence and stereotypical episodes of neuronal activity - slow wave events. However, it remains unclear which macroscopic signal is related to these active periods of the slow wave rhythm. We used optic fiber-based calcium recordings of local neural populations in cortex and thalamus to detect neurophysiologically defined slow calcium waves in isoflurane anesthetized rats. The individual slow wave events were used for an event-related analysis of simultaneously acquired whole-brain BOLD fMRI. We identified BOLD responses directly related to onsets of slow calcium waves, revealing a cortex-wide BOLD correlate: the entire cortex was engaged in this specific type of slow wave activity. These findings demonstrate a direct relation of defined neurophysiological events to a specific BOLD activity pattern and were confirmed for ongoing slow wave activity by independent component and seed-based analyses. |
| first_indexed | 2024-04-12T16:44:24Z |
| format | Article |
| id | doaj.art-9ac62130abc94424adcacb1a069bbd22 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:44:24Z |
| publishDate | 2017-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-9ac62130abc94424adcacb1a069bbd222022-12-22T03:24:39ZengeLife Sciences Publications LtdeLife2050-084X2017-09-01610.7554/eLife.27602Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium wavesMiriam Schwalm0https://orcid.org/0000-0003-4162-2298Florian Schmid1Lydia Wachsmuth2Hendrik Backhaus3Andrea Kronfeld4Felipe Aedo Jury5Pierre-Hugues Prouvot6Consuelo Fois7Franziska Albers8Timo van Alst9Cornelius Faber10https://orcid.org/0000-0001-7683-7710Albrecht Stroh11https://orcid.org/0000-0001-9410-4086Focus Program Translational Neurosciences, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany; GRADE Brain, Goethe Graduate Academy, Goethe University Frankfurt am Main, Frankfurt, GermanyDepartment of Clinical Radiology, University Hospital Münster, Münster, GermanyDepartment of Clinical Radiology, University Hospital Münster, Münster, GermanyFocus Program Translational Neurosciences, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, GermanyFocus Program Translational Neurosciences, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, GermanyFocus Program Translational Neurosciences, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, GermanyFocus Program Translational Neurosciences, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, GermanyFocus Program Translational Neurosciences, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Clinical Radiology, University Hospital Münster, Münster, GermanyDepartment of Clinical Radiology, University Hospital Münster, Münster, GermanyDepartment of Clinical Radiology, University Hospital Münster, Münster, GermanyFocus Program Translational Neurosciences, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, GermanySpontaneous slow oscillation-associated slow wave activity represents an internally generated state which is characterized by alternations of network quiescence and stereotypical episodes of neuronal activity - slow wave events. However, it remains unclear which macroscopic signal is related to these active periods of the slow wave rhythm. We used optic fiber-based calcium recordings of local neural populations in cortex and thalamus to detect neurophysiologically defined slow calcium waves in isoflurane anesthetized rats. The individual slow wave events were used for an event-related analysis of simultaneously acquired whole-brain BOLD fMRI. We identified BOLD responses directly related to onsets of slow calcium waves, revealing a cortex-wide BOLD correlate: the entire cortex was engaged in this specific type of slow wave activity. These findings demonstrate a direct relation of defined neurophysiological events to a specific BOLD activity pattern and were confirmed for ongoing slow wave activity by independent component and seed-based analyses.https://elifesciences.org/articles/27602slow wavesBOLD fMRIcalcium recordings |
| spellingShingle | Miriam Schwalm Florian Schmid Lydia Wachsmuth Hendrik Backhaus Andrea Kronfeld Felipe Aedo Jury Pierre-Hugues Prouvot Consuelo Fois Franziska Albers Timo van Alst Cornelius Faber Albrecht Stroh Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves eLife slow waves BOLD fMRI calcium recordings |
| title | Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves |
| title_full | Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves |
| title_fullStr | Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves |
| title_full_unstemmed | Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves |
| title_short | Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves |
| title_sort | cortex wide bold fmri activity reflects locally recorded slow oscillation associated calcium waves |
| topic | slow waves BOLD fMRI calcium recordings |
| url | https://elifesciences.org/articles/27602 |
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