Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-brain barrier integrity and function

Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-brain barrier integrity and function

The implementation of combined antiretroviral therapy (cART) significantly reduces the mortality associated with human immunodeficiency virus (HIV) infection. However, complications such as HIV-associated neurocognitive disorders (HAND) remain a major health concern. We hypothesized that the toxicit...

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Bibliographic Details
Main Authors: Chang Huang, Tozammel Hoque, Reina Bendayan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
blood-brain barrier
antiretroviral drugs (ARVs)
efavirenz
dolutegravir
bictegravir
ARV toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1118580/full

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