A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea
"nIntroduction: Chemotherapeutic drugs used to treat cancer may cause nausea and emesis by inducing the release of 5-hydroxytryptamine (5-HT) in the small intestine. Blockage of 5-HT3 receptors in the small intestine by 5-HT3 receptor antagonists might prevent the nausea and vomiting associ...
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Format: | Article |
Language: | English |
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Tehran University of Medical Sciences
2009-04-01
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Series: | International Journal of Hematology-Oncology and Stem Cell Research |
Subjects: | |
Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16093.pdf&manuscript_id=16093 |
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author | Shahrbanou Keyhanian O Taziki MM Saravi Z Fotokian |
author_facet | Shahrbanou Keyhanian O Taziki MM Saravi Z Fotokian |
author_sort | Shahrbanou Keyhanian |
collection | DOAJ |
description | "nIntroduction: Chemotherapeutic drugs used to treat cancer may cause nausea and emesis by inducing the release of 5-hydroxytryptamine (5-HT) in the small intestine. Blockage of 5-HT3 receptors in the small intestine by 5-HT3 receptor antagonists might prevent the nausea and vomiting associated with chemotherapy for cancer. The aim of this study was to compare the efficacy and tolerability of the 5-HT3 receptor antagonists (granisetron) and granisetron plus dexamethasone in the treatment of acute chemotherapy induced digestive emesis and nausea. "nMaterials and Methods: Patients on their first course of emetic chemotherapy (cisplation or doxorubicin based regimen) were randomly placed into two treatment groups. Group A received a one-time administration of granisetron 3 mg, IV and group B received granisetron plus dexamethasone 8 mg IV. For each study the drug were administered one time, 30 minutes before infusion of chemotherapy emetic agent. For the efficacy assessment, response data were recorded every 6 hours for a total of 24 hours, after the start of the chemotherapy infusion. "nResults: A total of 138 patients [86 males, 52 females with amean age of 48 (a range between 15-82 years)] were involved in the study . Of these, 125 were evaluable. "nDiscussion: The ability of granisetron plus dexamethason to prevent acute emesis was significantly better than, administering granisetron alone (66.7% vs 42.8% respectively) (p<0.001). "nThe combination of granisetron and low-dose dexamethasone is superior to granisetron alone to control acute emetic episodes in patients receiving emetogenic chemotherapy. |
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format | Article |
id | doaj.art-9acc9c52423e489ab9cda81f7069d4f8 |
institution | Directory Open Access Journal |
issn | 2008-3009 2008-2207 |
language | English |
last_indexed | 2024-03-12T09:20:21Z |
publishDate | 2009-04-01 |
publisher | Tehran University of Medical Sciences |
record_format | Article |
series | International Journal of Hematology-Oncology and Stem Cell Research |
spelling | doaj.art-9acc9c52423e489ab9cda81f7069d4f82023-09-02T14:33:24ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-30092008-22072009-04-01322730A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and NauseaShahrbanou KeyhanianO TazikiMM SaraviZ Fotokian"nIntroduction: Chemotherapeutic drugs used to treat cancer may cause nausea and emesis by inducing the release of 5-hydroxytryptamine (5-HT) in the small intestine. Blockage of 5-HT3 receptors in the small intestine by 5-HT3 receptor antagonists might prevent the nausea and vomiting associated with chemotherapy for cancer. The aim of this study was to compare the efficacy and tolerability of the 5-HT3 receptor antagonists (granisetron) and granisetron plus dexamethasone in the treatment of acute chemotherapy induced digestive emesis and nausea. "nMaterials and Methods: Patients on their first course of emetic chemotherapy (cisplation or doxorubicin based regimen) were randomly placed into two treatment groups. Group A received a one-time administration of granisetron 3 mg, IV and group B received granisetron plus dexamethasone 8 mg IV. For each study the drug were administered one time, 30 minutes before infusion of chemotherapy emetic agent. For the efficacy assessment, response data were recorded every 6 hours for a total of 24 hours, after the start of the chemotherapy infusion. "nResults: A total of 138 patients [86 males, 52 females with amean age of 48 (a range between 15-82 years)] were involved in the study . Of these, 125 were evaluable. "nDiscussion: The ability of granisetron plus dexamethason to prevent acute emesis was significantly better than, administering granisetron alone (66.7% vs 42.8% respectively) (p<0.001). "nThe combination of granisetron and low-dose dexamethasone is superior to granisetron alone to control acute emetic episodes in patients receiving emetogenic chemotherapy.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16093.pdf&manuscript_id=16093 Nausea, Vomiting, Chemotherapy, Granisetron, Dexamethasone |
spellingShingle | Shahrbanou Keyhanian O Taziki MM Saravi Z Fotokian A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea International Journal of Hematology-Oncology and Stem Cell Research Nausea, Vomiting, Chemotherapy, Granisetron, Dexamethasone |
title | A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea |
title_full | A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea |
title_fullStr | A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea |
title_full_unstemmed | A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea |
title_short | A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea |
title_sort | randomized comparison of granisetron plus dexamethason with granisetron alone for the control of acute chemotherapy induced emesis and nausea |
topic | Nausea, Vomiting, Chemotherapy, Granisetron, Dexamethasone |
url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16093.pdf&manuscript_id=16093 |
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