A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea

"nIntroduction: Chemotherapeutic drugs used to treat cancer may cause nausea and emesis by inducing the release of 5-hydroxytryptamine (5-HT) in the small intestine. Blockage of 5-HT3 receptors in the small intestine by 5-HT3 receptor antagonists might prevent the nausea and vomiting associ...

Full description

Bibliographic Details
Main Authors: Shahrbanou Keyhanian, O Taziki, MM Saravi, Z Fotokian
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2009-04-01
Series:International Journal of Hematology-Oncology and Stem Cell Research
Subjects:
Online Access:http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16093.pdf&manuscript_id=16093
_version_ 1797720499825934336
author Shahrbanou Keyhanian
O Taziki
MM Saravi
Z Fotokian
author_facet Shahrbanou Keyhanian
O Taziki
MM Saravi
Z Fotokian
author_sort Shahrbanou Keyhanian
collection DOAJ
description "nIntroduction: Chemotherapeutic drugs used to treat cancer may cause nausea and emesis by inducing the release of 5-hydroxytryptamine (5-HT) in the small intestine. Blockage of 5-HT3 receptors in the small intestine by 5-HT3 receptor antagonists might prevent the nausea and vomiting associated with chemotherapy for cancer. The aim of this study was to compare the efficacy and tolerability of the 5-HT3 receptor antagonists (granisetron) and granisetron plus dexamethasone in the treatment of acute chemotherapy induced digestive emesis and nausea. "nMaterials and Methods: Patients on their first course of emetic chemotherapy (cisplation or doxorubicin based regimen) were randomly placed into two treatment groups. Group A received a one-time administration of granisetron 3 mg, IV and group B received granisetron plus dexamethasone 8 mg IV. For each study the drug were administered one time, 30 minutes before infusion of chemotherapy emetic agent. For the efficacy assessment, response data were recorded every 6 hours for a total of 24 hours, after the start of the chemotherapy infusion. "nResults: A total of 138 patients [86 males, 52 females with amean age of 48 (a range between 15-82 years)] were involved in the study . Of these, 125 were evaluable. "nDiscussion: The ability of granisetron plus dexamethason to prevent acute emesis was significantly better than, administering granisetron alone (66.7% vs 42.8% respectively) (p<0.001). "nThe combination of granisetron and low-dose dexamethasone is superior to granisetron alone to control acute emetic episodes in patients receiving emetogenic chemotherapy.
first_indexed 2024-03-12T09:20:21Z
format Article
id doaj.art-9acc9c52423e489ab9cda81f7069d4f8
institution Directory Open Access Journal
issn 2008-3009
2008-2207
language English
last_indexed 2024-03-12T09:20:21Z
publishDate 2009-04-01
publisher Tehran University of Medical Sciences
record_format Article
series International Journal of Hematology-Oncology and Stem Cell Research
spelling doaj.art-9acc9c52423e489ab9cda81f7069d4f82023-09-02T14:33:24ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-30092008-22072009-04-01322730A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and NauseaShahrbanou KeyhanianO TazikiMM SaraviZ Fotokian"nIntroduction: Chemotherapeutic drugs used to treat cancer may cause nausea and emesis by inducing the release of 5-hydroxytryptamine (5-HT) in the small intestine. Blockage of 5-HT3 receptors in the small intestine by 5-HT3 receptor antagonists might prevent the nausea and vomiting associated with chemotherapy for cancer. The aim of this study was to compare the efficacy and tolerability of the 5-HT3 receptor antagonists (granisetron) and granisetron plus dexamethasone in the treatment of acute chemotherapy induced digestive emesis and nausea. "nMaterials and Methods: Patients on their first course of emetic chemotherapy (cisplation or doxorubicin based regimen) were randomly placed into two treatment groups. Group A received a one-time administration of granisetron 3 mg, IV and group B received granisetron plus dexamethasone 8 mg IV. For each study the drug were administered one time, 30 minutes before infusion of chemotherapy emetic agent. For the efficacy assessment, response data were recorded every 6 hours for a total of 24 hours, after the start of the chemotherapy infusion. "nResults: A total of 138 patients [86 males, 52 females with amean age of 48 (a range between 15-82 years)] were involved in the study . Of these, 125 were evaluable. "nDiscussion: The ability of granisetron plus dexamethason to prevent acute emesis was significantly better than, administering granisetron alone (66.7% vs 42.8% respectively) (p<0.001). "nThe combination of granisetron and low-dose dexamethasone is superior to granisetron alone to control acute emetic episodes in patients receiving emetogenic chemotherapy.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16093.pdf&manuscript_id=16093 Nausea, Vomiting, Chemotherapy, Granisetron, Dexamethasone
spellingShingle Shahrbanou Keyhanian
O Taziki
MM Saravi
Z Fotokian
A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea
International Journal of Hematology-Oncology and Stem Cell Research
Nausea, Vomiting, Chemotherapy, Granisetron, Dexamethasone
title A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea
title_full A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea
title_fullStr A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea
title_full_unstemmed A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea
title_short A Randomized Comparison of Granisetron Plus Dexamethason with Granisetron alone for the Control of Acute Chemotherapy-Induced Emesis and Nausea
title_sort randomized comparison of granisetron plus dexamethason with granisetron alone for the control of acute chemotherapy induced emesis and nausea
topic Nausea, Vomiting, Chemotherapy, Granisetron, Dexamethasone
url http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16093.pdf&manuscript_id=16093
work_keys_str_mv AT shahrbanoukeyhanian arandomizedcomparisonofgranisetronplusdexamethasonwithgranisetronaloneforthecontrolofacutechemotherapyinducedemesisandnausea
AT otaziki arandomizedcomparisonofgranisetronplusdexamethasonwithgranisetronaloneforthecontrolofacutechemotherapyinducedemesisandnausea
AT mmsaravi arandomizedcomparisonofgranisetronplusdexamethasonwithgranisetronaloneforthecontrolofacutechemotherapyinducedemesisandnausea
AT zfotokian arandomizedcomparisonofgranisetronplusdexamethasonwithgranisetronaloneforthecontrolofacutechemotherapyinducedemesisandnausea
AT shahrbanoukeyhanian randomizedcomparisonofgranisetronplusdexamethasonwithgranisetronaloneforthecontrolofacutechemotherapyinducedemesisandnausea
AT otaziki randomizedcomparisonofgranisetronplusdexamethasonwithgranisetronaloneforthecontrolofacutechemotherapyinducedemesisandnausea
AT mmsaravi randomizedcomparisonofgranisetronplusdexamethasonwithgranisetronaloneforthecontrolofacutechemotherapyinducedemesisandnausea
AT zfotokian randomizedcomparisonofgranisetronplusdexamethasonwithgranisetronaloneforthecontrolofacutechemotherapyinducedemesisandnausea