Use of Physiologically-Based Kinetics Modelling to Reliably Predict Internal Concentrations of the UV Filter, Homosalate, After Repeated Oral and Topical Application

Use of Physiologically-Based Kinetics Modelling to Reliably Predict Internal Concentrations of the UV Filter, Homosalate, After Repeated Oral and Topical Application

Ethical and legal considerations have led to increased use of non-animal methods to evaluate the safety of chemicals for human use. We describe the development and qualification of a physiologically-based kinetics (PBK) model for the cosmetic UV filter ingredient, homosalate, to support its safety w...

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Bibliographic Details
Main Authors: Abdulkarim Najjar, Andreas Schepky, Christopher-Tilman Krueger, Matthew Dent, Sophie Cable, Hequn Li, Sebastien Grégoire, Laurene Roussel, Audrey Noel-Voisin, Nicola J. Hewitt, Estefania Cardamone
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
homosalate
physiologically-based kinetics models
UV filter
plasma concentration
dermal application
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.802514/full

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