Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool
Background: We investigated the prevalence of and the factors associated with a high risk of osteoporotic fractures in Korean patients with ankylosing spondylitis (AS). Methods: This was a multicenter, retrospective study including 219 AS patients from five university hospitals; the control group wa...
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/10/2830 |
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| author | Ji-Won Kim Sunghoon Park Ju-Yang Jung Hyoun-Ah Kim Seong-Ryul Kwon Sang Tae Choi Sung-Soo Kim Sang-Hyeon Kim Chang-Hee Suh |
| author_facet | Ji-Won Kim Sunghoon Park Ju-Yang Jung Hyoun-Ah Kim Seong-Ryul Kwon Sang Tae Choi Sung-Soo Kim Sang-Hyeon Kim Chang-Hee Suh |
| author_sort | Ji-Won Kim |
| collection | DOAJ |
| description | Background: We investigated the prevalence of and the factors associated with a high risk of osteoporotic fractures in Korean patients with ankylosing spondylitis (AS). Methods: This was a multicenter, retrospective study including 219 AS patients from five university hospitals; the control group was selected by matching age and sex with those of the AS patients. The fracture risk was evaluated based on bone mineral density (BMD) measured by dual-energy X-ray absorptiometry and the fracture risk assessment tool (FRAX) with/without BMD. Results: The mean age of the patients was 47.6 years, and 144 (65.8%) patients were men. According to the WHO criteria and FRAX with/without BMD, the candidates for pharmacological treatment were 44 (20.1%), 20 (13.2%), and 23 (15.1%) patients, respectively, significantly more than those in the healthy control group. Among them, the proportion of patients receiving osteoporosis treatment was 39.1–75%. In logistic regression analysis, menopause was an independent factor for the high risk of fracture according to the WHO criteria and FRAX with/without BMD. C-reactive protein level (odds ratio (OR) 3.8 and OR 6) and glucocorticoid use (OR 1.5 and OR 1.7) were associated with a high risk of osteoporotic fracture based on FRAX without BMD and osteoporosis diagnosed according to the WHO criteria. Conclusions: Our study suggests that both FRAX and WHO criteria may be complementary for treatment decisions to reduce osteoporotic fractures in patients with AS. |
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| language | English |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-9acfb0dccbab4e23987f81c8500ca65b2023-11-23T11:35:31ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011110283010.3390/jcm11102830Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment ToolJi-Won Kim0Sunghoon Park1Ju-Yang Jung2Hyoun-Ah Kim3Seong-Ryul Kwon4Sang Tae Choi5Sung-Soo Kim6Sang-Hyeon Kim7Chang-Hee Suh8Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Radiology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Rheumatology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Rheumatology, Ajou University School of Medicine, Suwon 16499, KoreaDivision of Rheumatology, Department of Internal Medicine, InHa University College of Medicine, Incheon 22332, KoreaDivision of Rheumatology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06973, KoreaDivision of Rheumatology, Department of Internal Medicine, Kangneung Asan Medical Center, Ulsan University College of Medicine, Kangneung 25440, KoreaDivision of Rheumatology, Department of Internal Medicine, Keimyung University College of Medicine, Daegu 41931, KoreaDepartment of Rheumatology, Ajou University School of Medicine, Suwon 16499, KoreaBackground: We investigated the prevalence of and the factors associated with a high risk of osteoporotic fractures in Korean patients with ankylosing spondylitis (AS). Methods: This was a multicenter, retrospective study including 219 AS patients from five university hospitals; the control group was selected by matching age and sex with those of the AS patients. The fracture risk was evaluated based on bone mineral density (BMD) measured by dual-energy X-ray absorptiometry and the fracture risk assessment tool (FRAX) with/without BMD. Results: The mean age of the patients was 47.6 years, and 144 (65.8%) patients were men. According to the WHO criteria and FRAX with/without BMD, the candidates for pharmacological treatment were 44 (20.1%), 20 (13.2%), and 23 (15.1%) patients, respectively, significantly more than those in the healthy control group. Among them, the proportion of patients receiving osteoporosis treatment was 39.1–75%. In logistic regression analysis, menopause was an independent factor for the high risk of fracture according to the WHO criteria and FRAX with/without BMD. C-reactive protein level (odds ratio (OR) 3.8 and OR 6) and glucocorticoid use (OR 1.5 and OR 1.7) were associated with a high risk of osteoporotic fracture based on FRAX without BMD and osteoporosis diagnosed according to the WHO criteria. Conclusions: Our study suggests that both FRAX and WHO criteria may be complementary for treatment decisions to reduce osteoporotic fractures in patients with AS.https://www.mdpi.com/2077-0383/11/10/2830ankylosing spondylitisosteoporosisosteoporotic fracturebone mineral densityfracture risk assessment tool |
| spellingShingle | Ji-Won Kim Sunghoon Park Ju-Yang Jung Hyoun-Ah Kim Seong-Ryul Kwon Sang Tae Choi Sung-Soo Kim Sang-Hyeon Kim Chang-Hee Suh Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool Journal of Clinical Medicine ankylosing spondylitis osteoporosis osteoporotic fracture bone mineral density fracture risk assessment tool |
| title | Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool |
| title_full | Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool |
| title_fullStr | Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool |
| title_full_unstemmed | Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool |
| title_short | Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool |
| title_sort | prevalence and factors of osteoporosis and high risk of osteoporotic fracture in patients with ankylosing spondylitis a multicenter comparative study of bone mineral density and the fracture risk assessment tool |
| topic | ankylosing spondylitis osteoporosis osteoporotic fracture bone mineral density fracture risk assessment tool |
| url | https://www.mdpi.com/2077-0383/11/10/2830 |
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