Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease
The burden of mental illness in young people with chronic liver disease is not known. In this population cohort study in England, we identified 358 individuals (aged ≤25 years) diagnosed with autoimmune hepatitis or liver disease related to cystic fibrosis and 1541 propensity-score-matched controls....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-09-01
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| Series: | BJPsych Open |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472422005506/type/journal_article |
| _version_ | 1811156929107460096 |
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| author | Wai Hoong Chang Graham R. Foster Deirdre A. Kelly Alvina G. Lai |
| author_facet | Wai Hoong Chang Graham R. Foster Deirdre A. Kelly Alvina G. Lai |
| author_sort | Wai Hoong Chang |
| collection | DOAJ |
| description | The burden of mental illness in young people with chronic liver disease is not known. In this population cohort study in England, we identified 358 individuals (aged ≤25 years) diagnosed with autoimmune hepatitis or liver disease related to cystic fibrosis and 1541 propensity-score-matched controls. By the first year of follow-up, the cumulative burden of psychiatric events in participants with liver disease was high compared with controls: anxiety disorder (6.87 per 100 individuals [95% CI 4.00–9.73] v. 2.22 [95% CI 1.37–3.07]), depression (5.10 [95% CI 2.83–7.37] v. 0.86 [95% CI 0.53–1.19]), substance misuse (10.61 [95% CI 9.50–11.73] v. 1.23 [95% CI 0.71–1.75]) and self-harm (3.09 [95% CI 1.12–5.05] v. 0.20 [95% CI 0.07–0.33]). Participants with liver disease had a 2-fold increase (OR = 1.94, 95% CI 1.45–2.58), a 2.5-fold increase (OR = 2.59, 95% CI 1.91–3.50) and 4.4-fold increase (OR = 4.44; 95% CI 3.46–5.71) in the risk of anxiety, depression and substance misuse, respectively. These findings highlight the need for effective intervention in psychiatric disorders in young people with rare liver disease. |
| first_indexed | 2024-04-10T04:58:14Z |
| format | Article |
| id | doaj.art-9ad11ac4decb412ab2160274e42d445c |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T04:58:14Z |
| publishDate | 2022-09-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-9ad11ac4decb412ab2160274e42d445c2023-03-09T12:29:21ZengCambridge University PressBJPsych Open2056-47242022-09-01810.1192/bjo.2022.550Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver diseaseWai Hoong Chang0Graham R. Foster1Deirdre A. Kelly2Alvina G. Lai3https://orcid.org/0000-0001-8960-8095Institute of Health Informatics, University College London, UKBarts Liver Centre, Blizard Institute, Queen Mary University of London, UKLiver Unit, Birmingham Women's & Children's Hospital, Birmingham, UK; and Institute of Immunology and Immunotherapy, University of Birmingham, UKInstitute of Health Informatics, University College London, UKThe burden of mental illness in young people with chronic liver disease is not known. In this population cohort study in England, we identified 358 individuals (aged ≤25 years) diagnosed with autoimmune hepatitis or liver disease related to cystic fibrosis and 1541 propensity-score-matched controls. By the first year of follow-up, the cumulative burden of psychiatric events in participants with liver disease was high compared with controls: anxiety disorder (6.87 per 100 individuals [95% CI 4.00–9.73] v. 2.22 [95% CI 1.37–3.07]), depression (5.10 [95% CI 2.83–7.37] v. 0.86 [95% CI 0.53–1.19]), substance misuse (10.61 [95% CI 9.50–11.73] v. 1.23 [95% CI 0.71–1.75]) and self-harm (3.09 [95% CI 1.12–5.05] v. 0.20 [95% CI 0.07–0.33]). Participants with liver disease had a 2-fold increase (OR = 1.94, 95% CI 1.45–2.58), a 2.5-fold increase (OR = 2.59, 95% CI 1.91–3.50) and 4.4-fold increase (OR = 4.44; 95% CI 3.46–5.71) in the risk of anxiety, depression and substance misuse, respectively. These findings highlight the need for effective intervention in psychiatric disorders in young people with rare liver disease.https://www.cambridge.org/core/product/identifier/S2056472422005506/type/journal_articleMental illnessanxietydepressionself-harmsubstance misuse |
| spellingShingle | Wai Hoong Chang Graham R. Foster Deirdre A. Kelly Alvina G. Lai Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease BJPsych Open Mental illness anxiety depression self-harm substance misuse |
| title | Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease |
| title_full | Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease |
| title_fullStr | Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease |
| title_full_unstemmed | Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease |
| title_short | Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease |
| title_sort | depression anxiety substance misuse and self harm in children and young people with rare chronic liver disease |
| topic | Mental illness anxiety depression self-harm substance misuse |
| url | https://www.cambridge.org/core/product/identifier/S2056472422005506/type/journal_article |
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