The Specific Immune Response after Vaccination against Neonatal Calf Diarrhoea Differs between Apparent Similar Vaccines in a Case Study
Neonatal calf diarrhoea (NCD) is a major health challenge with a negative impact on farm profitability, calf welfare and antimicrobial use. Neonatal calves are particularly sensitive to enteric infections. Thus, a key point for prevention is minimising infectious pressure and maximising specific imm...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/5/1238 |
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| author | Román Gonzalez Laura Elvira Carlos Carbonell Geert Vertenten Lorenzo Fraile |
| author_facet | Román Gonzalez Laura Elvira Carlos Carbonell Geert Vertenten Lorenzo Fraile |
| author_sort | Román Gonzalez |
| collection | DOAJ |
| description | Neonatal calf diarrhoea (NCD) is a major health challenge with a negative impact on farm profitability, calf welfare and antimicrobial use. Neonatal calves are particularly sensitive to enteric infections. Thus, a key point for prevention is minimising infectious pressure and maximising specific immune responses. An amount of 120 dams not previously vaccinated against NCD were randomly allocated to one of three study groups: negative control versus two vaccinated groups (A and B). In the control group, the average level of antibodies was significantly low for both BoCV and ETEC (15.6 and 13.9% in the colostrum samples, respectively), demonstrating the importance of dam vaccination. Indeed, the level of specific immunity was significantly increased for BoCV and ETEC with dam vaccination using both one-shot vaccines versus the control group. Moreover, the statistical analysis revealed a significantly higher level of antibodies for BoCV and ETEC in colostrum samples in vaccine A versus vaccine B and the control group. In accordance, the calf serum demonstrated a significantly higher level and greater homogeneity of antibodies against BoCV and ETEC in the Vaccine A group versus other experimental groups (<i>p</i> < 0.05). In conclusion, this study demonstrated a different specific immune response for the pathogens depending on the vaccine used to control NCD in cows. |
| first_indexed | 2024-03-10T11:59:07Z |
| format | Article |
| id | doaj.art-9ad158da8b8541e898e423bd20283fc7 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T11:59:07Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-9ad158da8b8541e898e423bd20283fc72023-11-21T17:05:08ZengMDPI AGAnimals2076-26152021-04-01115123810.3390/ani11051238The Specific Immune Response after Vaccination against Neonatal Calf Diarrhoea Differs between Apparent Similar Vaccines in a Case StudyRomán Gonzalez0Laura Elvira1Carlos Carbonell2Geert Vertenten3Lorenzo Fraile4Practitioner SAT Prolesa, 27614 Galicia, SpainRuminant Technical Team, MSD Animal Health Spain, 37188 Salamanca, SpainRuminant Technical Team, MSD Animal Health Spain, 37188 Salamanca, SpainMSD Animal Health, Wim de Körverstraat 35, 5831 AN Boxmeer, The NetherlandsDepartment of Animal Science, University of Lleida—Agrotecnio Center, 25198 Lleida, SpainNeonatal calf diarrhoea (NCD) is a major health challenge with a negative impact on farm profitability, calf welfare and antimicrobial use. Neonatal calves are particularly sensitive to enteric infections. Thus, a key point for prevention is minimising infectious pressure and maximising specific immune responses. An amount of 120 dams not previously vaccinated against NCD were randomly allocated to one of three study groups: negative control versus two vaccinated groups (A and B). In the control group, the average level of antibodies was significantly low for both BoCV and ETEC (15.6 and 13.9% in the colostrum samples, respectively), demonstrating the importance of dam vaccination. Indeed, the level of specific immunity was significantly increased for BoCV and ETEC with dam vaccination using both one-shot vaccines versus the control group. Moreover, the statistical analysis revealed a significantly higher level of antibodies for BoCV and ETEC in colostrum samples in vaccine A versus vaccine B and the control group. In accordance, the calf serum demonstrated a significantly higher level and greater homogeneity of antibodies against BoCV and ETEC in the Vaccine A group versus other experimental groups (<i>p</i> < 0.05). In conclusion, this study demonstrated a different specific immune response for the pathogens depending on the vaccine used to control NCD in cows.https://www.mdpi.com/2076-2615/11/5/1238immune responsecowneonatal diarrhoeavaccinationpassive immunity |
| spellingShingle | Román Gonzalez Laura Elvira Carlos Carbonell Geert Vertenten Lorenzo Fraile The Specific Immune Response after Vaccination against Neonatal Calf Diarrhoea Differs between Apparent Similar Vaccines in a Case Study Animals immune response cow neonatal diarrhoea vaccination passive immunity |
| title | The Specific Immune Response after Vaccination against Neonatal Calf Diarrhoea Differs between Apparent Similar Vaccines in a Case Study |
| title_full | The Specific Immune Response after Vaccination against Neonatal Calf Diarrhoea Differs between Apparent Similar Vaccines in a Case Study |
| title_fullStr | The Specific Immune Response after Vaccination against Neonatal Calf Diarrhoea Differs between Apparent Similar Vaccines in a Case Study |
| title_full_unstemmed | The Specific Immune Response after Vaccination against Neonatal Calf Diarrhoea Differs between Apparent Similar Vaccines in a Case Study |
| title_short | The Specific Immune Response after Vaccination against Neonatal Calf Diarrhoea Differs between Apparent Similar Vaccines in a Case Study |
| title_sort | specific immune response after vaccination against neonatal calf diarrhoea differs between apparent similar vaccines in a case study |
| topic | immune response cow neonatal diarrhoea vaccination passive immunity |
| url | https://www.mdpi.com/2076-2615/11/5/1238 |
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