Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?

Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?

Abstract Background Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to rise during critical illness. FGF21 is a pleiotropic hormone that mediates adaptive responses to tissue injury and repair in various chronic pathological condit...

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Bibliographic Details
Main Authors: Wouter Vankrunkelsven, Steven Thiessen, Sarah Derde, Ellen Vervoort, Inge Derese, Isabel Pintelon, Hanne Matheussen, Alexander Jans, Chloë Goossens, Lies Langouche, Greet Van den Berghe, Ilse Vanhorebeek
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Skeletal Muscle
Subjects:
FGF21
Critical illness
Muscle mass
Muscle weakness
Mitochondrial function
Endoplasmic reticulum stress
Online Access:https://doi.org/10.1186/s13395-023-00320-4

Internet

https://doi.org/10.1186/s13395-023-00320-4

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